简介:ThethermalstabilityofNewZealandculturerabbitmusclealdolasewasinvestigatedbydifferentialscanningcalorimetryinthewatercontentrange0.23-3.70gwaterpergprotein.Theexperimentalresultsshowedthatatwatercontentsbelow0.47g/g,anendothermicpeakwasobservedandatwatercontentsabove0.57g/g,anendothermicandanexothermicpeakwerebothobservedonDSCthermogram.Thermaldenaturationresultoftheenzymeandtherelationshipbetweentwotransitiontemperaturesandwatercontentswerefirstreportedinthispaper.Uptonowwehavenotseenanysimilarreportsconcerningtheexothermictransition.
简介:ObjectiveToExplorethemechanismoftheacupunctureonposanenopausalosteoporo-sis.MethodOnehundredWistarfemalerats(6month-old)wererandomlydividedintotwogroups:O-variectomizedgroupandsham-operatedgroup.After3monthsofoperation,threeratswerechosentomeasurethebonehistomorphometricindexes.Thentheovariectomizedratsweredistributedrandomlytoacupuncturegroupandyigaininggroupandnormalsalinegroupandcontrol2group,theratswererespec-tivelytreatedbyacupunctureandyigainingandnormalsaline.Afterthetreatmentforthreecourse,allratswerecollectedbloodfromtheateriafemoralis,thelevelsofcalcitoninweremeasuredbyIRMA.thebonehistomorphometricindexesandC-cellinthyroidfollicleweredetected.ResultsThelevelsofcalcitoninofacupuncturegroupwereincreasingsignificantlycomparingwiththeyigaininggroupandthenormalsalinegroupandthecontrol2group(p<0.05),buttherewerenoevidentdifferenceinthelevelsofcal-citoninbetweentheacupuncturegroupandthesham-operatedgroup.Themeantrabecularbonewidthandthetmbecuharbonevolume%ofacupuncturegroupwereincreasingmorethanthatofthenormalsalinegroupandthecontrol2group(p<0.05);themeanmarrowcavitywidthandthemarrowcavityvol-ume%werederreasingmorethanthatofthenomalsalinegroupandthecontrol2group(P<0.05);thenumberofC-cellinthyroidfollicleoftheacupuncturegroupwereincreasingmorethanthatoftheothergroupsexceptthesham-operatedgroup.ConclusionAcupuncturecaneffectivelytreatthepost-menopausalosteoporosisbystrengtheningtheabilityoftheC-cellinthyroidfolliclewhichcanimprovethelevelsofcalcitonininserum.
简介:Thispaperreviewsthestudiesonacoustoelectriceffectinextrinsicsemiconductormaterialsusedinvariousscientificandothermeasurements.Ahistoricalreviewofearlierfindingsisgivenwithspecialreferencetoassociatedmechanisms.Acoustoelectricstudiesinsolidstatedevioesrequirefurtherattentionandtheworkdoneinthisareaisalsodiscussed.
简介:Thecooperativeprincipleisanimportanttheoryofpragmatics,concerninghowtomaximallyachievecommunicativegoal.Whiletranslationservesasacommunicativemedium,itshouldalsoobservetheconversationalrules—cooperativeprincipletoachievetheequivalenteffect.Thispapertriestoexploretheissuefromtheperspectiveofcooperativeprinciple.
简介:Withdevelopmentofmoderngeoscience,particularlydevelopmentofenvironmentalsciences,thecontemporarysoilscienceisundergoinggreatchangesinbothresearchcontentsandscope.Soilisnotonlyacertainsubstanceoracertainindependentnaturalhistoricalbodybutalsoasphericlayerwithpeculiarstructureandfunctionsintheearthsystem.Fromtheviewpointofthegeo-biospheresystemofearth,soilsciencedoesdealnotonlywiththesoilsubstancespersebutalsomoreimportantlywiththerelationshipsamongsoil,theotherspheresandthehumansurvivalenvironmentinviewofthe"pedosphere",Thisistheneworientationofsoilsciencetodayandwillaffectprofoundlythestudiesonthehumansurvivalenvironmentandglobalchanges,Tothrowmorelightonthissubject,thepresentpaperintendstoaddresstheconceptionofpedosphereanditsroleinglobalchanges,AlsoaddressedareseriesofenvironmentalissuesinChinaandtheirrelationstotheglobalchanges.Moreover,researchorientationandprioritiesareindicated,includingexploitationandprotectionofthesoilresources,soilfertilityandsustainableagriculturaldevelopment,constructionoftheecologicalenvironment,andthematerialcyclinginpedosphereanditsrelationtoglobalchanges.
简介:Thethermodynamicpropertiesofcrystalscanberoutinelycalculatedbydensityfunctionaltheorycalculationscombiningwithquasi-harmonicapproximation.BasedonthemethoddevelopedrecentlybyWuandWentzcovitch(PhysRevB79:104304,2009)andWu(PhysRevB81:172301,2010),weareabletofurtherabinitioincludeanharmoniceffectonthermodynamicpropertiesofcrystalsbyoneadditionalcanonicalensemblewithnumbersofparticle,volumeandtemperaturefixed(NVT)moleculardynamicsimulations.Ourstudyindicatesthatphonon–phononinteractioncausestherenormalizedphononfrequenciesofwadsleyitedecreasewithtemperature.ThisisconsistentwiththeRamanexperimentalobservation.TheanharmonicfreeenergyofwadsleyiteisnegativeanditsheatcapacityatconstantpressurecanexceedtheDulong–Petitlimitathightemperature.Theanharmonicitystillsignificantlyaffectsthermodynamicpropertiesofwadsleyiteatpressureandtemperatureconditionscorrespondtothetransitionzone.
简介:IntheprocessofsolvingEulervectorsbasedonGNSShorizontalmovementfield,thenumberofestimatedparameterscanaffectEulervectorresults.Thisissueisanalyzedthroughtheoreticaldeductionandpracticalexampleinthispaper.Firstly,thedifferencebetweentheresultsofEulervectorsindifferentsolvingmodelsisdeduced.Meanwhile,basedonGNSShorizontalmovementfieldintheChinesemainlandfrom2004to2007,twocommonmodels(RRMandREHSM)areusedtodiscusstheimpactofsolvingmodelsonEulervectorsandthefollow-upstudy.Theresultshowsthatthemaximumvalueofthedifferenceinablock’sentirerotationcanreach2.6mm/a,andshouldnotbeignored.Therefore,theresultsofhorizontalmovementaredifferentusingdifferentkinematicblockmodels,andthisshouldbepaidmoreattentionintheanalysisofcrustalhorizontalmovement.
简介:<正>Geodynamiccompositeeffectprinciplewhichisproducedonthebasisofearthmovementisabasictheoryofmechanics.Itbelongstoanewviewpointandconcept.Comparedwithgravityeffectofgeocentrictheory,anideologicalsystemofmechanicstakingthesunasreferencecoordinateispresentedtoexplaineasilynaturalphenomenaandprob-lemswhichgoagainstgravityeffect:volcano,earthquake,horizontalstress,magmaticactivityandcrustalmovement.Itcanbewidelyusedingeology,mining,engineering,geologicdisaster…Themainconclu-sionanddeductionareasfollows.
简介:Theeffectofthermalcyclingunderloadingonmartensitictransformationandtwo-wayshapememoryeffectwasinvestigatedforTi-49.8at.pctNialloy.ItisshownthatMsandMftemperatureincreasewithincreasingthenumberofcycles,whileAsandAftemperaturedecreaseduringthermalcycling.Thetotalstrainεtandpermanentstrainεpincreasewithincreasingappliedstressandnumberofcycles.Thetwo-wayshapememoryeffectcanbeimprovedbyproperthermalcyclingtrainingunderloading,whileexcessivelyhighappliedstressresultsinthedeteriorationofTWSME.Thereasonforthechangesinmartensitictransformationcharacteristicsandtwo-wayshapememoryeffectduringthermalcyclingunderloadingisdiscussedbasedontheanalysisofmicrostructurebyTEMobservations.
简介:Objective:Toinvestigateimmune-relatedgeneticbackgroundinbilateralsuddensensorineuralhearingloss(SSNHL).Casereportandmethods:Thecaseisa45-year-oldmanpresentingwitha7-yearhistoryofbilateralprofoundSSNHL.Bloodbiochemicaltestingdemonstratedincreasedlevelsoftotalcholesterol(5.88mmol/L).TestsforhepatitisBshowedapositiveantibodyagainstthehepatitisBcoreantigen.ComplementC3wasbelowthenormalvalue,andcomplementC4andIgGwereinthelowerrangeofnormalvalues.CTimagesshowedanormalinnerearandvestibularaqueductbutroundwindowmembranousossificationonbothsides.Atotalnumberof232immuneassociatedgenesweresequencedusingthenextgenerationsequencingtechnique.Results:Mutationsweredetectedin5genes,includingthephosphoinositide3-kinasecatalyticsubunitdelta(PIK3CD),caspaserecruitmentdomain-containingprotein9(CARD9),complementfactorH-related(CFHR2),immunoglobulinlambda-likepolypeptide1Protein(IGLL1),andtransmembranechannel-likegenefamily8(TMC8).InthePIK3CDgene,aC896Tsubstituteinexon7wasdetected.Thismutationcausesprimaryimmunodeficiencyandisanautosomaldominantdisease.Conclusion:ThePIK3CDC896TmutationresponsibleforprimaryimmunodeficiencymaycontributetotheonsetofbilateralSSNHLwithsubsequentrapidprogression.
简介:VertebrategenomesarecharacterizedwithCpGdeficiency,particularlyforGC-poorregions.TheGCcontent-relatedCpGdeficiencyisprobablycausedbycontext-dependentdeaminationofmethylatedCpGsites.ThishypothesiswasexaminedinthisstudybycomparingnucleotidefrequenciesatCpGflankingpo-sitionsamonginvertebrateandvertebrategenomes.Thefindingisatransitionofnucleotidepreferenceof5'Tto5'Aattheinvertebrate-vertebrateboundary,indi-catingthatalargenumberofCpGsiteswith5TsweredepletedbecauseofglobalDNAmethylationdevelopedinvertebrates.Atgenomelevel,weinvestigatedCpGobserved/expected(obs/exp)valuesin500bpfragments,andfoundthathigherCpGobs/expvalueisshowninGC-poorregionsofinvertebrategenomes(exceptseaurchin)butinGC-richsequencesofvertebrategenomes.WenextcomparedGCcontentatCpGflankingpositionswithgenomicaverage,showingthattheGCcontentislowerthantheaverageininvertebrategenomes,buthigherthanthatinvertebrategenomes.Theseresultsindicatethatalthough5'Tand5'AaredifferentininducingdeaminationofmethylatedCpGsites,GCcontentisevenmoreimportantinaffectingthedeaminationrate.Inallthetests,theresultsofseaurchinaresimilartovertebratesperhapsduetoitsfractionalDNAmethylation.CpGdeficiencyisthereforesuggestedtobemainlyaresultofhighmutationratesofmethylatedCpGsitesinGC-poorregions.
简介:Themainrequirementsforbatteryseparatorsarehighporositywhichcanservepathwaysoflithiumionandspaceforgelelectrolytestoimpregnateinamembraneandmechanicalstrengthtoalloweasyhandlingforbatteryassembly.Generally,itappearsthetrade-offrelationshipbetweentheporosityandmechanicalstrengthofthemembrane.PVdFcompositemembranescontainingnano-sizeclayswereusedtoimprovethemechanicalstrengthofthemembranewithoutaffectingthemembraneporosity.Thecompositemembraneswerepreparedbyphaseinversionmethodcontrollingthemembranepreparationconditionssuchasretentiontime.Theresultantmembranesshowincreasedmechanicalpropertieswithsimilarmembraneporosityaround80%comparedtothepristinePVdFmembrane.Incorporationofnonoclaycanbeconsideredasaneffectivemethodtoimprovethemechanicalstrengthinporousmembranesupports,especiallyinaseparator.
简介:Thispaperanalysestheoreticallytheeffectoftransportationandhousingsubsidiesonurbansprawl,modalchoicedecisionsandurbanspatialstructureusingaspatialgeneralequilibriummodelinamonocentriccitywithtwotransportmodes.Ouranalysisshowsthatpublictransitsubsidyleadstourbanshrink,whilstsubsidizingautomobileandhousingmakethecitysprawl.Wealsofindtheeffectsoftheotherfactorsonurbansprawl,suchashouseholdsincomeanddemand,rurallandrent,theincometaxrate,thetotalfixedcostofpublictransitandautomobileandthetravellingmarginalcostofpublictransitandautomobile.Furthermore,thispaperalsostudieshowtomaximizetheurban-area-widespatialequilibriumutilitylevel.
简介:Samplesofpolyphenylsilsisquioxane(PPSQ)usingCaF2orMgF2asthemaincatalystshadbeenpreparedunderdifferentpolymerizationconditions.TheresultsweretreatedonanorthogonaldesignL9(34).Allweight-averagemolecularweights(MW)ofPPSQhadbeenmeasuredbygelpermeationchromatography(GPC).Effectsofpolymerizationconditionsincludingreactiontemperature,compositionofthedualcatalysts(CaF2orMgF2andDCC),mixtureofsolventsandreactiontimeonMWofPPSQhavebeendiscussed.ThequantityofthecatalystsisthemostimportantfactorthataffectsMWofPPSQ.Reactiontemperatureisthesecondimportantfactor.AppropriatepolymerizationconditionhasbeenestablishedtogetPPSQwithhighMW.
简介:Theeffectofdifferentkindsofcomonomerswithorwithoutflexiblechainonproper-tiesofcopolyesters,suchastransitiontemperature,crystallizationvelocity,crystallinityandsizeofcrystallites,isstudied.Theexperimentalresultsindicatetheobviousdiffer-enceinpropertiesbetweencomonomerswithiso-andortho-structureofphenylringandcomonomerswithflexiblechain.Theinfluenceofchemicalstructureofcomonomersonpropertiesofcopolyestersisdiscussed.