简介：ObjectivesToob-servetheeffectofdifferentestrogenlevelsonthesecretoryfunctionofvascularendothelialcellsoffemalerats,andstudytheeffectofmodulationofestrogenlevelontheexpressionofvascularcelladhesionmolecule-1andtheconcentrationofestrogenreceptorinvascularendothelialcells.MethodsRadioim-munologywasusedtomeasuretheserumconcentrationofendothelinandPGI2,andcopper-cadmiumreductionwasemployedtomeasuretheserumcontentofnitrogenmonoxide.Radioligandbindingandflowcy-tometrywereusedtomeasuretheexpressionofestrogenreceptorandvascularcelladhesionmolecule(VCAM-1)ofvascularendothelialcellsrespectively.Results1.TheserumconcentrationofnitricoxideandPGI2decreasedwhentheovariesoffemaleratswereremoved.Inovariectomizedrats,givenestrogen,theconcentrationrose(P<0.05),buttheplasmaconcentrationofendothelinwasadversetoit.2.Theconcentrationofestrogenreceptorofvascularendothelialcel

简介：Objective:Toevaluatethetreatmentforpatientswithmajorvascularinjuriesassociatedwithtraumaticorthopedicinjuries.Methods:Atotalof196patients,agedfrom4-67yearswiththemeanageof29.88years,hadmajorvascularinjuriesassociatedwithtraumaticorthopedicinjuriesandweretreatedinourhospitalinaperiodof44years.Themostcommonmechanismoftraumawasblunttrauma(67.3%),openinjuriesaccountedfor32.4%and54.5%oftheinjurieswerelocatedinthelowerextremities.Thevascularinjuryfrequentlyhappenedinthefemoralartery(26.7%)andpoplitealartery(20.3%).Thetreatmentprincipleconsistedofaggressiveresuscitation,Dopplerimagingandstableboneinternalfixationwithsubsequentvascularrepairanddebridement.Thevascularrepairforinjuriesincludedend-to-endanastomosis(80cases,39.6%),interpositionalveingraft(94,46.5%),vasculardecompressionthroughfracturedistraction(18,8.9%),arterialligation(6,3.0%),veinpatch(2,1.0%),bypassgraft(2,1.0%),venousrepairincludingautogenousveingraft(9,24.3%)andligation(28,75.7%)andprophylacticalfasciotomy(15,7.4%).Postoperativeamputationwasperformedin16cases(16.3%).Results:Nointraoperativedeathwasobservedandallfracturesunitedwithin6months.Limbsweresalvagedin180patients(91.8%).Amongthesepatients,earlycomplicationswerefoundin19patients(9.7%)andlatecomplicationswereobservedin8patients(4.1%).Conclusions:Awell-organizedapproach,basedonaspecifictreatmentprinciple,notonlyimprovesclinicaloutcomebutalsodoesgoodtoexcellentfunctionalrecoveryforpatientswithsevereorthopedicinjuriesandconcomitantvascularlesion.

简介：锁骨下的脉管的损害说明所有脉管的损害的1%-5%。如果没及时发现或迅速设法，锁骨下的脉管的损害是可能的引起出血性的吃惊甚至死亡。从通过2003的8月的1998的三月，有锁骨下的脉管的损害的15个盒子的一个总数在我们的部门被对待。细节在这份报告的redescribed。

简介：转变生长因素(TGF)-尾家庭成员是多功能的cytokines在细胞上得到他们的效果包括endothelial和墙壁的细胞，经由特定的类型我和类型IIserine/threoninekinase受体和细胞内部的Smad抄写因素。为表明小径部件的TGF-尾家庭的猛烈老鼠模型在合适的蛋黄囊angiogenesis揭示了他们的批评重要性。在人的基因研究在这些发信号的部件连接了变化到象世袭出血性的毛细管扩张，主要肺的高血压和Marfan症候群那样的特定的心血管的症候群。在这评论，我们在我们TGF-尾受体在脉管的生物学和疾病发信号的角色的理解的现在的最近的进展，并且讨论这怎么可以被申请治疗。

简介：Apoptosisisaformofgeneticallyprogrammedcelldeath,whichplaysakeyroleinregulationofcellularityinavarietyoftissueandcelltypesincludingthecardiovasculartissues.Underbothphysiologicalandpathophysiologicalconditions,variousbiophysiologicalandbiochemicalfactors,includingmechanicalforces,reactiveoxygenandnitrogenspecies,cytokines,growthfactors,oxidizedlipoproteins,etc.,mayinfluenceapoptosisofvascularcells.TheFas/Fasligand/caspasedeath-signalingpathway,Bcl-2proteinfamily/mitochondria,thetumorsuppressivegenep53,andtheproto-oncogenec-mycmaybeactivatedinatheroscleroticlesions,andmediatesvascularapoptosisduringthedevelopmentofatherosclerosis.Abnormalexpressionanddysfunctionoftheseapoptosis-regulatinggenesmayattenuateoracceleratevascularcellapoptosisandaffecttheintegrityandstabilityofatheroscleroticplaques.Clarificationofthemolecularmechanismthatregulatesapoptosismayhelpdesignanewstrategyfortreatmentofatherosclerosisanditsmajorcomplication,theacutevascularsyndromes.

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简介：DearEditor,IamSatoruKase,fromtheDepartmentofOphthalmology,FacultyofMedicineandGraduateSchoolofMedicine,HokkaidoUniversity,SapporoCity,Japan.Iwritetopresentacaseofneurofibromatosistype1(NF1)showingmassivehemorrhageduringinvolutionalblepharoptosissurgery.

简介：Photoacousticophthalmoscopy(PAOM)isanovelimagingmodality,whichiscapableofnon-invasivelydetectingopticalabsorptionpropertiesintheretina.WevisualizethemicrovasculatureinretinaandchoroidinalbinomouseusingPAOMguidedbyspectral-domainopticalcoherencetomography.Sincealbinomousecharacterizesbylackingmelanininretinalpigmentepithelium(RPE),PAOMilluminationlasercanpenetratethroughtheRPEontochoroid,andconsequentlyprovidesvolumetricvisualizationofchorioretinalvasculaturesasaresultofstronghemoglobinopticalabsorption.Thehigh-qualitychorioretinalmicrovascularimagingacquiredbyPAOMimpliesitsgreatpotentialinunderstandingpathologicalmechanismsanddevelopingtherapeuticstrategiesformajorchorioretinaldiseasesthatcorrelatewithvasculardisorders.

简介：Objective:Toinvestigatetheneointimaformationandtheexpressionofmonocytechemoattractantprotein-1(MCP-1)andtumornecrosisfactor-α(TNF-α)incuff-inducedvascularinjuryinmousemodel,andtoexaminetheeffectofangiotensinIItype1receptor(AT1)blocker,olmesartan,onMCP-1andTNF-αexpressionandconsequentlyvascularremodeling.Methods:Vascularinjurywasinducedbypolyethylenecuff-placementaroundthemousefemoralartery.SomemiceweretreatedwithAT1receptorblocker,olmesartan,atthedoseof3mg*kg-1*day-1withanosmoticminipump.Neointimaformationandtheproliferationofvascularsmoothmusclecells(VSMCs)weremeasuredbymorphometricanalysisandbromodeoxyuridine(BrdU)incorporation.MCP-1andTNF-αexpressionwasdetectedbyWesternblotandimmunohistochemicalstaining.Results:Weobservedneointimaformation14daysaftercuffplacementaswellasVSMCsproliferationinthemediaandneointima.CuffplacementalsoinducedMCP-1andTNF-αexpressioninthemediaandneointimathattheVSMCsspecificallyexisted.Treatmentofmicewitholmesartanatadoseof3mg*kg-1*day-1,whichdidnotinfluencesystolicbloodpressure,significantlydecreasedneointimaformationandtheproliferationofVSMCs.OlmesartanalsoinhibitedMCP-1andTNF-αexpressionintheinjuredarteries.Conclusions:OurresultsdemonstratethatblockadeofAT1receptorinhibitsMCP-1andTNF-αexpressionandtherebyimprovesvascularremodeling.

简介：AbstractTraumatic peripheral vascular injury is a significant cause of disability and death either in civilian environments or on the battlefield. Penetrating trauma and blunt trauma are the most common forms of vascular injuries. Besides, iatrogenic arterial injury (IAI) is another pattern of vascular trauma. The management of peripheral vascular injuries has been improved in different environments and wars. There are different types of vascular injuries, such as vasospasm, contusion, intimal flaps, intimal disruption or hematoma, external compression, laceration, transection and focal wall defects, etc. The main clinical manifestations of vascular injuries are shock following massive hemorrhage and limb necrosis due to tissue and organ ischemia. Ultrasound, computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are most valuable for assessment of peripheral vascular injuries. Angiography remains the gold standard for diagnosing vascular trauma. Immediate hemorrhage control and rapid restoration of blood flow are the primary goals of vascular trauma treatment. There are many operative treatment methods for vascular injuries, such as vascular suture or ligation, vascular wall repair and vascular reconstruction with blood vessel prostheses or vascular grafts. Embolization, balloon dilation and covered stent implantation are the main endovascular techniques. Surgical operation is still the primary treatment for vascular injuries. Endovascular treatment is a promising alternative, proved to be safe and effective, and preferred selection for patients. In summary, rapid diagnosis and timely surgical intervention remain the mainstays of the treatment. However, many issues need to be resolved by further studies.

简介：Thepaperpresentsadetailedanalysisofexperimentaldatainordertocharacterizetheelasticpropertiesofarteries.Suchanalysiswouldprovideagoodbasisforevaluationofbiomimeticvasculargrafts.Sincethelatterneedstoexhibitsimilarpropertiesofnativetissue,itisimportanttoaccuratelycharacterizethebiomimeticsampleinalargerangeofappliedstresses.Thestress-strainpropertiesvaryaccordingtothespecificpathology(e.g.arteriosclerosis,aneurism)andthetissuegraftmustbechosencorrectly.Twomodelsareproposedinthispaperonthestress-straincharacteristics.Anextensionforfrequency-domainanalysisisprovidedforoneofthemodels.Thecomparisonbetweenvasculargraftsandnativetissueforcarotidandthoracicarteriesinpigsareingoodagreementwithresultsfromliterature.Theproposedexperimentalmethodofferssuitableparametersforidentifyingmodelswhichcharacterizebothelasticityandstiffnesspropertiesoftheanalyzedtissues(stress-strain).Theproposedmodelsshowgoodperformanceincharacterizingtheintrinsicmaterialproperties.

简介：Autoantibodiesagainsttheα1-adrenoceptorwhichhadagonistactivityasnorepinephrinemightplayrolesintheprogressionofhypertension,butwhethertheautoantibodiescouldinducevascularremodelingasnorepinephrineisnotclear.Inthispaper,themodelswithantibodiesagainsttheα1-adrenoceptorweremadebyimmunizingWistarratswiththesynthesizedthesecondextracellularloopofα1-adrenoceptorpeptides.Thehomo-agemaleWistarratsreceivedBSAinthesameimmunizingmannerandmalespontaneoushypertensiverats(SHR)wereusedascontrol.Alltheratswereraisedforoneyear.Thebloodpressureandmorphologicalchangesofarteriesweremeasured.Intheend,despitethesystolicbloodpressureofimmunizedratshadnodifferencewithnormalcontrol,themediathicknessofaortasandratioofmediatolumeninthethird-orderarteriesofmesentericvasculaturewereincreasedinimmunizedrats.Theobservationwithelectronmicroscopeshowedthatthemitochondriaofvascularsmoothmusclecells(VSMCs)hadnotablehyperplasia,andtheinterstitialcollagenfibrilwasincreasedtoo.Theeffectsofpurifiedantibodiesagainstα1-adrenoceptorontheproliferationofculturedVSMCs,andtheexpressionsofc-jun,c-fosandα1-adrenoceptorweredetected.TheresultsshowedthattheantibodiescouldpromotetheproliferationofculturedVSMCs,andenhancetheexpressionofc-junbothinvitroandinvivo.Soweconcludedthatantibodiesagainsttheα1-adrenoceptorcouldcontributetovasculardamagesinratsbystimulatingthegrowthofVSMCswhichmightbecausedbytheincreasedc-junexpression,andmightplayparticularrolesinthepathologicalchangesofhypertension.

简介：在与对脉管的损伤的照顾和治疗感兴趣的从在整个世界的同事一起的知识的国际交换的精神，我们在脉管的损伤上从西方的世界提供选择历史的思考。而有很多个关键个人和许多事件，在我们的写对我们重要，我们不实质上对被另外的文化并且，特别地写汉语的知道任何东西。中国外科医生在第一之中在切断的极限的重新种植园高度成功，这很好在全世界被认出，修理受伤动脉和静脉。另外，我们认识到在世界的另外的部分有贡献，它不一起对我们众所周知。从说的阿拉伯语的贡献世界分开因为有周期的简短参考，出现在脑海。我们提供我们希望将有至少一位中国外科医生，将为我们提供在对在西方的世界外面设法脉管的损伤的重要历史的贡献上分享他们的观点的利益的观点，并且，特别地，英语说文学。再次，我们用说的阿拉伯语鼓励我们的同事向我们提供他们发展的观点和脉管的损伤的管理的世界。

简介：为回顾1949-2004年针灸治疗血管性头痛的状况，以推动针灸临床的发展，根据《中国现代针灸信息数据库》数据，计量分析针灸治疗血管性头痛的临床文献。从1956年起针灸治疗血管性头痛的文献报道逐年增加，呈平稳增长趋势，临床治疗以针刺为主，临床选穴以邻近取穴与辨证取穴相结合。

简介：ObjectiveToexploretherelationshipbetweensuddensensorineuralhearingloss(SSNHL)andvascularriskfactors(includingserumlipidsanduricacid).MethodThisisaretrospectiveanalysisof100casesofSSNHLseenattheDrumTowerHospital,NanjingMedicalUniversity,betweenJan.2007andApr.2008。Patienthistory,bloodtestresultsandimagingscanswereanalyzed.Levelsoftriglyceride(TG),cholesterols(CHO),highdensitylipoprotein-cholesterol(HDL-CH),lowdensitylipoprotein-cholesterol(LDL-CH),apolipoproteinAI(ApoAI),apolipoproteinB(ApoB)anduricacid(UA)fromthesepatientswerecomparedwithacontrolgroupof56patientstreatedforvocalcordpolypsornasalseptumdeviationduringthesameperiod.Patientswithhypertension,diabetes,heart,brain,liverorkidneydisordersareexcludedfromthepresentinvestigation.ResultsHDLCHlevelwashigherandUAlevellowerinthestudygroupthanthecontrolgroup(P<0.05).HDL-CHandUAshowednosignificantdifferencesamongdifferentage-groups(P>0.05).TherewerenosignificantdifferencesinthelevelsofTG,CHO,LDL-CH,ApoAIandApoB(P>0.05).ConclusionThesedataindicatethatmetabolicdisturbancesofserumlipidsand/oruricacidmaybepotentialriskfactorsforSSNHL

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简介：Objective:Toinvestigatethebindingcharacteristicsofendothelialcell(EC)withLPSfreefromtheparticipationofserumfactors.Methods:LaserconfocalmicroscopewasemployedintheobservationofthebindingofECwithFITC-LPS.TheKDandthebindingsitesofeachECwerecalculatedbyradioligandbindingassayofreceptors(RBA)using[3H]-LPS.Results:ThebindingofECwithLPSwassaturable,timeandconcentrationdependentanditcouldbecompetedwithoverdosedLPSofthesametype.Thefluorescencemainlydistributedincytoplasm,especiallynearthenucleus,whichcouldalsobestained.Conclusions:TheremightbesomespecificLPSbindingsitesexistingonEcsandLPScouldfunctionintracellularily.

简介：AbstractPurpose:To explore the significance of traditional vascular reconstruction and covered stent for limb salvage after subclavian artery injury.Methods:Patients with subclavian artery injury admitted to Beijing Jishuitan Hospital from January 2010 to December 2018 were retrospectively analyzed. All the injuries have been confirmed by intraoperative exploration, computed tomography angiography or digital subtraction angiography. Complete or partial amputation injuries were excluded. Mild artery defect or partial intimal damage was treated by inter-ventional implantation, while other patients received open surgeries, including direct suture of small defect less than 2 cm and transplantation with autologous vein or artificial blood when the defect was more than 2 cm. Patients were divided into open surgery group and stent implantation group based on the treatment they received. Patients were followed up at 2 weeks (first stage) and 6 months (second stage) after operation to investigate limb salvage. Student's t-test was used to compare the general data between two groups and Chi-square test to analyze the rate of limb salvage.Results:Altogether 50 cases of subclavian artery injury were treated, including 36 cases of open surgery and 14 cases of stent implantation. Combination of nerve injury was observed in 27 cases (75.0%) in open surgery group and 12 cases (85.7%) in stent implantation group. Amputation developed in 3 cases with open surgery and 1 case with stent implantation. Consequently the rate of successful limb salvage was respectively 91.7% (33/36) and 92.9% (13/14), revealing no significant difference (p > 0.05).Conclusion:Rapid reconstruction of blood circulation is crucial following subclavian artery injury, no matter what kinds of treatment strategies have been adopted. Interventional stent implantation can achieve a good effect for limb salvage.