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简介：镁为生物医学的应用作为革命可被细菌破坏的金属被建议了。然而，镁的腐蚀太快速，不能匹配织物愈合的率并且另外，展出局部性的腐蚀机制。因此为他们的实际使用控制镁的腐蚀行为是必要的。这篇论文包括地在代表性的镁的开发考察研究进步基于合金，包括象体积一样的Mg-Ca，Mg-Sr，Mg-Zn和Mg-REE合金系统金属性的玻璃。他们的微观结构，机械性质和腐蚀行为上的alloying元素的影响被总结。机械并且腐蚀性质做镁合金也演员组合金与那些比较被讨论。而且，这评论也盖住为生物医学的应用在镁合金上在可能减解的涂层的领域里执行的研究。钙磷酸盐和可被细菌破坏的聚合物涂层基于使用的不同准备技术被讨论。我们也在镁合金底层的腐蚀行为上比较不同涂层的效果。

简介：多晶的四角形的氧化锆的低温度老化行为被调查在阶段转变发生在这个过程期间上探索效果。XRD分析为阶段鉴定被进行并且对单斜晶的阶段转变四角形被决定。四角形的氧化锆多晶体的老化仅仅在标本的表面上与对单斜晶的阶段转变四角形的3个mol%Y2O3扳机做了，当在标本的体积内的穿入是很有限的时。在机械性质的细微减少也为40h在老化以后被观察。转变动力学表演标本上的一个成核和生长机制出现在在水环境的低温度老化主导。

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简介：Mg-Caalloyshavebeenproposedtobeanewcandidateforbiodegradablemetalmaterialsinthepresentstudy.Mg-1Ca,Mg-5CaandMg-20Ca(wt%)havebeenpreparedandtheprimarypropertiesrelatedtotheirbiomedicalapplicationhavebeeninvestigatedbyX-raydiffraction,SEMobservation,tensile,electrochemicalandimmersiontests.TheexperimentalresultsshowthatwiththeincreaseofCaconcentration,theworkingabilityofMg-Caalloybecomesworse.OnlyMg-1CaandMg-5Caalloyspecimenscanbehotrolledi...

简介：Thefracturetoughnessofhardbiomaterials,suchasnacre,bovinehoofwallandbeetlecuticle,isassociatedwithfibrousorlamellarstructuresthatdeflectorstopgrowingcracks.Theirhardnessandreducedmodulusweremeasuredbyusingananoindenterinthispaper.Micro/nanoscalecracksweregeneratedbynanoindentationusingaBerkovichtip.Nanoindentationofnacreandbovinehoofwallresultedinpile-uparoundtheindent.Itwasfoundthatthefracturetoughness(KC)ofbovinehoofwallisthemaximum,thesecondisnacre,andtheelytracuticleofdungbeetleistheleastone.

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简介：综合C-phycocyanins(CPC)做了硅石简历材料被SEM和赌注表面区域分析测量描绘。CPC的形态学做了硅石简历材料显示硅石簇的表面被很多硅石粒子与一种平均尺寸形成在30和40nm之间。硅石本身是有2.95nm的平均毛孔直径的多孔的结构。有他们的直径的毛孔为84.07%的不到5nm报道。另外，CPC能作为一根荧光灯的蛋白质探针被利用监视蛋白质封装的影响并且在硅石矩阵学习矩阵和蛋白质相互作用和蛋白质的稳定性。蛋白质封装硅石材料的申请要求简历分子在潜在地相反的工业条件上保留简历活动和稳定性。在答案或在硅酸盐矩阵的CPC在相片漂白由紫外光线罐头结果照耀，而在硅石的蛋白质少些被影响。在缓冲区答案的CPC的测量相片损坏率常数是比在硅石矩阵的CPC的快25倍的。然而，在硅石矩阵或磷酸盐缓冲区的CPC的一生是未受影响的。这些研究建议CPC的那个陷阱进硅石矩阵能不仅维持他们的生物活动而且显著地改进他们的相片稳定性。

简介：AbstractInfectious diseases are severe public health events that threaten global health. Prophylactic vaccines have been considered as the most effective strategy to train the immune system to recognize and clear pathogenic infections. However, the existing vaccines against infectious diseases have several limitations, such as difficulties in mass manufacturing and storage, weak immunogenicity, and low efficiency of available adjuvants. Biomaterials, especially functional polymers, are expected to break through these bottlenecks based on the advantages of biocompatibility, degradability, controlled synthesis, easy modification, precise targeting, and immune modulation, which are excellent carriers and adjuvants of vaccines. This review mainly summarizes the application of immunologically effective polymers-enhanced vaccines against viruses- and bacteria-related infectious diseases and predicted their potential improvements.

简介：Anewconceptfordevelopmentofmetallicbiomaterialsisproposedinthisarticle,i.e.,acertainbio-functioncanberealizedforametalimplantthroughcontinuousreleaseofadesignedbio-functionalmetalelementfromsurfaceofthemetalimplantinthebodyenvironment.ThiscreativeideahasbeenverifiedtobepossiblebyseveraldifferentinvitroandinvivoexperimentalevidencesontheCu-bearingstainlesssteelsandmagnesiumbasedmetals.ItwasindicatedthatatraceamountofCureleasefromtheCu-bearingsteelscouldhaveobviousbio-functionsofreductionofthein-stentrestenosis(ISR),anti-bacterialinfection,inhibitingtheinflammatorycellsandevenpromotingtheearlyosteogenesis.Furthermore,thedegradationofmagnesiumbasedmetalsinbonescouldpromotethenewboneformation,enhancethebonemineraldensityfortheosteoporosismodeledanimal,andevenhavestronganti-bacterialabilityandstrongcytotoxicitytobonetumorcellsduetotheenhancementofpH.Specialbio-functionwithsatisfiedload-bearingcapacityformetallicbiomaterialswillbringhigherapplicationvaluesfortheimplantmadeofthisnovelmaterial.Thisisanattractivedirectionforresearchanddevelopmentwithmanychallenges,butthefinalsuccesswillbemuchbeneficialtothemajorityofpatients.

简介：干细胞治疗旁边在医疗保持大诺言，例如，代替失去的房间，重新组成健康房间人口并且另外在干细胞的使用作为为因素和基因交货的车辆。胚胎的干细胞正直地由于他们在vivo.Tissue特定的干细胞在胚胎区分进任何房间类型的证明能力吸引了大兴趣是不管多么已经在在诊所的使用，并且最近包含人的神经干细胞(NSC)的第一系统的医药试用治疗被发射了。Thereare还克服的许多障碍和过程到改善。保证进步在医药我们文件结束干细胞增加了管理干细胞特征的分子的机制的基本知识是必要的。这里，我们在房间治疗的各种各样的方面在NSC上提供文学的评论，与使用简历材料控制NSCcharacteristics，区别，和交货的潜力的主要焦点。我们在啮齿类动物模型在内长、移植的NSC的特征上从研究总结结果神经病学并且癌症疾病，和热点在聚合物相容性的最近的前进和处于regulatingNSC状态和命运的适用性。我们建议特殊设计的聚合物的发展，如此的ashydrogels，是一个关键问题在中枢神经系统改进干细胞治疗的结果。

简介：AbstractThe outbreak of viral infections are serious threat to human life and health. However, there remains to be a lack of effective treatments and prophylactic measures against some viral infections. Additionally, there are numerous challenges in developing vaccines and antiviral drugs (e.g., antibodies and protein inhibitors), such as low immunogenicity of vaccines, difficulties in storing vaccines, instability and easy degradation of protein drugs, and lack of drug selectivity. Protein-based biomaterials can interact with antiviral drugs or vaccines to achieve synergistic or enhanced effects, making them a promising antiviral tool with many advantages. Silk fibroin has the potential to stabilize liquid vaccines at room temperature. Elastin-like polypeptide modification can improve the stability and yield of virus-neutralizing antibodies. Drugs in combination with β-casein or serum albumin (SA) has good prospects in treating human immunodeficiency virus (HIV) infections. Moreover, the greatest value of SA as a protein-based antiviral material lies in its ability to target the liver and macrophages. In the future, combination with SA (direct conjugation or encapsulation with drugs) may be a better treatment strategy for viral hepatitis and HIV infections because it leads to fewer adverse reactions. In addition, self-assembling protein nanoparticles (SApNPs) are found to improve vaccine immunogenicity. The combination of multiple viral immunogens and multiple SApNPs produces different promising vaccine candidates, thus highlighting the value of SApNPs. This review aimed to discuss the current status and future prospects for the development of protein-based biomaterials to combat viral infections.

简介：Poly(ethyleneglycolmonomethylether)methacrylate(PEGMM)wassynthesizedbymeansofthereactionofmethacrylylchloridewithsodiummonomethylpolyethyleneglycoxideandwascharacterizedbyFTIR,~1H-NMR,andultravioletspectrometries.Aseriesofpoly(vinylalcohol)-graft-PEGMM(PVA-g-PEGMM)andmethylmethacrylate-PEGMMcopolymer(PMMA-PEGMM)werepreparedandtestedforantithrombogenicityinvitro.TheresultsindicatethattheantithrombogenicityofthecopolymersbasicallyincreaseswiththeincreasingoftheDPofpolyoxyethylene(POE)chainandtendstoaplateauaftertheDParound114,i.e.thelongchainstructureofPOEisfavourabletotheantithrombogenicityofitscopolymers;moreover,theextentoftheimprovementofantithrombogenicityalsorelatestothePEGMMcontentofthecopolymersandthekindofthematrixthatthePOEchainsarelocatedon.Theseresultsareconsistentwiththeanticipationofthehypothesisofmaintainingproteinsnormalconformationsforbloodcompatiblebioraaterials.

简介：Ti47Cu38xZr7.5Fe2.5Sn2Si1Ag2Nbx(x?=?0，1，2；at%)体积有优异简历腐蚀抵抗的金属性的眼镜(BMG)被铜模子扔综合。尽管到Ti-Cu-Zr-Fe-Sn-Si-AgBMG的Nb的次要的增加稍微减少形成眼镜的能力(GFA)，忍受Nb基于Ti的合金能是在体积的casted有直到3的直径的玻璃质的杆形式?公里。有Nb的Cu的部分替换在提高基于Ti的BMG的简历腐蚀抵抗上是有效的，这被发现。Potentiodynamic极化大小证明基于Ti的BMG的Nb增加导致更高开电路的潜力和pitting潜力以及更低的被动电流在丝等的密度答案。电气化学的阻抗光谱学(EIS)结果显示与Nb内容增加，基于Ti的BMG的费用转移电阻价值变得更大，证明表面氧化物电影是更保护的。忍受Nb基于Ti的BMG也展出在比得上Ti-6Al-4V的vitrobiocompatibility好合金。提高的简历腐蚀电阻，在vitro优秀biocompatibility和忍受Nb基于Ti的BMG的好机械性质为生物医学的应用是有利的。

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简介：Anovelclassofsegmentedcopolymers,dimethyldiphenylpolysiloxane/poly(oxytetramethylene)-polyurea(PSPEU),wassynthesizedfromα,ω-bis(γ-aminopropyl)dimethyldiphenylpolysiloxane(APMPS),whichwaspreparedbymeansofbasicring-openingcopolymerizationofoctamethylcyclotetrasiloxane,hexaphenylcyclotrisiloxaneand1,3-bis(γ-aminopropyl)tetramethyldisiloxane.TherelationshipsbetweenthediphenylsiloxycontentsandthepropertiesofAPMPS,includingrefractiveindex,glasstransitiontemperature,solubilityparameteraswellasthermalstability,wereinvestigated;meanwhile,thethermalstability,dynamicmechanicalproperties,mechanicalproperiesaswellastheantithrombogenicityinvitroofthePSPEUwerealsorevealed.