简介：目的探索60Co-γ辐照条件下影响左氧氟沙星降解的因素（辐照剂量、初始浓度、N2/O2饱和及自由基清除剂等）。方法分别配制不同初始浓度的左氧氟沙星溶液（10、50、100mg·L-1、100mg·L-1＋N2饱和、100mg·L-1＋O2饱和、100mg·L-1＋10%叔丁醇、左氧氟沙星粉末）,经不同辐照剂量（0.3、0.6、1、2.5、5、10kGy）的60Co-γ辐照后,利用HPLC法测定溶液中剩余左氧氟沙星的含量。结果左氧氟沙星的降解受到初始浓度及辐照剂量的影响,初始浓度越低,辐照剂量越大,降解越彻底。而粉末状态几乎不降解。与N2或空气饱和相比,O2饱和显著降低了左氧氟沙星的降解率。添加自由基清除剂叔丁醇后,左氧氟沙星的降解明显受到了抑制。结论60Co-γ辐照处理可以成为有效降解水体中有害物质的新方法。对左氧氟沙星而言,浓度越低,辐照剂量越大,降解越彻底。

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简介：2003年12月24日21：00我科收治1例因煤气热水器沐浴引起CO中毒昏迷患者，在早期首选高压氧(HBO)纯氧吸人治疗，治疗中主管护师陪舱，把好“加压、稳压、减压”护理关，使病人在首次HBO治疗中得到精心护理，转危为安，现将护理方法及体会介绍如下。

简介：1喉癌喉咽癌CO2激光手术简史激光是20世纪60年代以来发展异常迅速的新科学技术,可以对生物组织产生强的热作用,从而实现对生物组织的切割、汽化和凝固。将激光技术应用于喉显微外科手术,

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简介：BACKGROUND:Duetothelackofautografttransplantrejection,Schwanncells(SCs)canpromotetheproliferationofembryonicstemcellsandtheinductionofdopaminergicneurons.Mesencephalicstemcellscanbeinducedtoproducedopaminergicneurons.Thetherapeuticeffectsofco-graftsofSCsandneuralstemcells(NSCs)deservesfurtherstudyandverificationinParkinsoniananimalmodels.OBJECTIVE:ToinvestigatetheeffectsofSchwanncellsandmesencephalicNSCco-graftsinParkinsoniananimalmodelsonanimalbehaviorandhistology.DESIGN:Randomizedcontrolledexperiment.SETTING:FudanUniversity;InstituteofNeuroscience,ChineseAcademyofSciences.MATERIALS:ThefollowinganimalswereobtainedfromtheExperimentalAnimalCenter,ShanghaiInstituteforBiologicalScience,ChineseAcademyofSciences:5Sprague-Dawleyrats,embryonicday(E)13-16;16neonatalSprague-Dawleyrats,postnatalday1-3;and18adultSDratsofbothgenders.Animalexperimentationmetanimalethicalapproval.METHODS:TheexperimentwasperformedattheDepartmentofAnatomy,HistologyandEmbryology,ShanghaiMedicalCenter,FudanUniversityfromSeptember2005toJanuary2007.ThemesencephalicNSCswereobtainedfromthebrainsofSDratsatE13-16,andSCswereharvestedfromthesciaticnervesofneonatalratsatday1-3.Hemiparkinsonianrats(n=18)wereselectedfortransplantationafterestimatingrotationalbehaviorinresponsetoapomorphineandwererandomlyassignedtothreegroups:controlgroup,NSCgroup,andco-graftgroup.Therewere6ratsineachgroup.Eitherphosphatebufferedsaline(PBS),NSCs,orSCsplusNSCsweretransplantedintotherightneostriatumofParkinsonianrats,respectively.MAINOUTCOMEMEASURES:①Rotationalbehaviorwasinducedbyapomorphine(0.05mg/kg,i.p.)2,4,6,8,and10weeksaftertransplantation,andthenumberofrotationswerecounted.②Differentiationandsurvivalofdopaminergicneuronsintherightneostriatumwerequantifiedbytyrosinehydroxylaseimmu

简介：AbstractIntroduction:Vitiligo and psoriasis are common skin diseases, while its co-occurrence in one patient is rare.Here, we reported a patient with co-occurrence of vitiligo and psoriasis.Case presentation:An 11-year-old girl developed depigmented patches on her right chin for 6 months. The noticed areas of depigmented skin steadily increased in size with no clinical symptoms. Wood’s lamp examination and laser scanning confocal revealed the clinical diagnosis of co-occurrence of vitiligo and psoriasis.Discussion:Speculations related to co-pathogenesis of vitiligo and psoriasis are still elusive, some explanations of this phenomenon like of isomorphic reaction, shared genetic basis of autoimmunity and inflammation, shared cellular immune pathways including Th1, Th17 and related cellular molecules such as TNF-α, IFN-α, IL-17 have been reported.Conclusion:The analysis and summary of the underlying association in co-occurrence of psoriasis and vitiligo may amplify future therapeutic options for both disease. Clinicians should pay attention to the methods that could simultaneously improve these two conditions.

简介：慢性扁桃体炎多由扁桃体炎反复发作，机体抵抗力减弱，或因隐窝引流不畅，聚积于隐窝内的微生物(抗体)长期与扁桃体炎接触所致变态反应性炎症，病人病程长，症状顽固，不易治愈，我科自1997年以来用CO2激光治疗慢性扁桃体炎取得了满意的疗效。现报道如下。

简介：本文通过分析了CO2压缩机在改造前的使用情况、存在的问题及其原因分析，然后根据分析制定改造方案。该改造取得了很好的效果，值得大力推广。

简介：摘要目的观察CO2激光破口清除痤疮内容物后再配合内服外用抗生素及维A酸软膏治疗痤疮的临床疗效。方法将120例患者随机分为2组。治疗组先予CO2激光破口清除痤疮内容物。两组患者均给予早、中午用甲硝唑凝胶、睡前用0.1%维A酸乳膏外涂，同时予阿奇霉素口服，每次0.5，服三日停四日，连续治疗30天为一疗程。结果治疗组和对照组总有效率分别为71.6%和28.3%，治疗组疗效明显高于对照组，差异有显著性﹙P＜0.05﹚。结论CO2激光破口清除痤疮内容物后再配合药物内服外用治疗痤疮疗效明显。

简介：摘要目的探究早期声门型喉癌CO2激光手术治疗的效果。方法选取本院2016年1月—2017年12月期间收治的早期声门型喉癌患者，共50例。随机分为两组，各25例。对照组实施常规手术治疗，观察组实施CO2激光手术治疗，对比两组预后效果。结果观察组术后复发率、并发症发生率低于对照组，5年生存率高于对照组。各项数据差异均具有统计学意义，P＜0.05。结论早期声门型喉癌CO2激光手术治疗后复发率较低，并发症较少，5年生存率较高。

简介：包茎、包皮过长是男科常见的一种疾病，我科采用CO2激光包皮套环切除术治疗包茎、包皮过长患者96例，取得了较满意的疗效，现报告如下。

简介：摘要一氧化碳严重中毒者昏迷至持续数小时甚至数天。常并发肺水肿心肌损害，血管神经性水肿，甚至引发急性肾功能衰竭等多脏器功能衰竭（MOSF）。如不及时抢救，可危机患者生命。2012年12月10日，我科收治了1例CO中毒致MOSF的患者，通过及时有效的吸氧，保持呼吸道通畅，严密观察病情变化，迅速采取有效措施防御并发症等系列抢救，精心护理，使患者转危为安。

简介：一起罕见的ＣＯ中毒事故调查报告芜湖市卫生防疫站（２４１０００）余文波，杨林新，陈康ＣＯ中毒时有报导，但因室外煤气管道泄漏，通过地表上层渗透至室内，造成人员中毒。１事发经过１９９４年１月１８日，本市某厂工人李某偕女友约２１：００时许进入其卧室同食面包，...

简介：【摘要】目的：评价纳洛酮在急诊CO中毒患者抢救中的价值。方法：选择2019年5月到2020年5月的急诊CO中毒患者94例，通过奇偶法的方式分成实验组（纳洛酮：47例）与对照组（常规抢救法：47例），分析苏醒时间、住院时间、并发症、抢救效果。结果：实验组的苏醒时间和住院时间低于对照组，P＜0.05，对照组的并发症高于实验组，P＜0.05。实验组抢救效果高于对照组，P＜0.05。结论：急诊CO中毒抢救的过程中采用纳洛酮不仅能够加快苏醒速度，还能提升抢救有效率，有着推广普及优势。

简介：摘要目的观察乌拉地尔对腹腔镜co2气腹导致的高血压的降压作用的临床效果。方法60例全麻下腹腔镜手术病人随机分为对照组(A组,n=30)和乌拉地尔组(B组,n=30),B组于气腹前经静脉推注乌拉地尔0.4mg/kg。记录A组与B组患者气腹前(T1)、气腹后1min(T2)、3min(T3)、5min(T4)、10min(T5)、20min(T6)、30min（T7）及放气后10min(T8)的SBP、DBP、HR的改变。结果A组气腹期间相应时点的SBP、DBP、HR与T1相比明显升高(P<0.01);而B组以上指标相应时点与T1相比无明显改变。结论乌拉地尔能很好地抑制和降低CO2气腹引起的血压变化。

简介：AbstractGrowing evidence suggests pollution and other environmental factors have a role in the development of tuberculosis (TB), however, such studies have never been conducted in Peru. Considering the association between air pollution and specific geographic areas, our objective was to determine the spatial distribution and clustering of TB incident cases in Lima and their co-occurrence with clusters of fine particulate matter (PM2.5) and poverty. We found co-occurrences of clusters of elevated concentrations of air pollutants such as PM2.5, high poverty indexes, and high TB incidence in Lima. These findings suggest an interplay of socio-economic and environmental in driving TB incidence.

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简介：BackgroundAtrialfibrillation(AF)isthemostcommonsustainedcardiacarrhythmiawithouteffectivetreatment.AFisassociatedwithatrialconductiondisturbancescausedbyelectricaland/orstructuralremodel-ing.Buttheroleofconnexin(Cx)43intheregulationofLtypecalciumchannel(LCC)remainsunclear.WehypothesizedthatCx43mightco-localizeandregulatetheLtypecalciumchannelcurrent(ICa,L).MethodsReal-timePCRandwhole-cellpatchclampwereusedtodetecttheexpressionofLCC1csubunitandthecurrentdensityofICa,L,beforeandafterCx43knockingdownrespectively.Theco-localizationofCx43withLCCwasinvestigatedbyco-immunoprecipitationandconfocalmicroscopy.ResultsKnockingdownofCx43significantlyinhibitedthecurrentdensityofICa,LthroughdecreasingthegeneexpressionofLCCα1cinculturedatrium-derivedmyocytes(HL-1cells).Cx43co-localizedwithLCCα1csubunitinatrialmyocytes.ConclusionsCx43regulatestheICa,LinatrialmyoctyesthroughLCC,representingapotentialpathogenicmechanisminatrialarrhythmias.