简介：CellResearchispleasedtoannouncethatDrDangshengLihasbeenappointedasthenewDeputyEditor-in-chiefforourjournal,startingMarch2006.DangshengreceivedhisBSdegree(inCellBiology)fromtheUniversityofScienceandTechnologyofChina,andobtainedhisPhD(inMolecularBiology)fromCornellUniversityGraduateSchoolofMedicalSciences.AfterextensivepostdoctoraltrainingatNewYorkUniversityMedicalCenter,hejoinedCellPressin2004toserveasanAssociateEditorforthepremiumbiologyjournalCell.DangshengwillbeinchargeofthescientificeditingoperationsofCellRe-

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简介：Objective:Tostudytheexpressionofdendriticcellsinhumanrenalcellcarcinomaandexplorethecause,sotorevealthemechanismofescapingimmunesurveillanceinRCC.Methods:TheexpressionsofCD83+DCS,CD1a+DCS,VEGFandTGF-β1intumoral,peritumoralandnormalkidneytissuesofRCCin30casesweredetectedbyimmunohistochemistryusingstreptavidin/peroxidese(SP)Results:CD83+DCSweremainlylocatedintheperitumoralareas;whereasCD1a+DCS、weremainlyretainedwithinthecancernests.ThenumberofCD83+DCSwasinverselycorrelatedwiththeclinicalstage(P<0.05);buttherewerenosignificantcorrelationsbetweenthenumberofCD1a+DCS、andtheclinicalstage(P>0.05).TheexpressionsofCD83+DCSandCD1a+DCShavesignificantdifferencebetweenthetumoral,peritumoralandnormalkidneytissues(P<0.001).TheexpressionofVEGFandTGF-β1weresignificantlylowerinsampleswithhighlyinfiltratingCD83+DCS(P<0.05);WhereasCD1a+DCSwerenot(P>0.05).Conclusion:DChasthetendencytogatheringintumor,butbecauseoftheimmunosuppressivecytokins,forexampleVEGFandTGF-β1,inhibitsthematurationofDC,therearelessmatureTIDCS(CD83+TIDCS)inthetumoraltissues,theyaremainlylocatedintheperitumoralareas.ThismaycontributetothemechanismofescapingimmunesurveillanceinRCC.

简介：Laryngealsquamouscellcarcinoma(LSCC)remainsahighlymorbidandfataldisease.Historically,ithasbeenamodelexamplefororganpreservationandtreatmentstratificationparadigms.Unfortunately,survivalforLSCChasstagnatedoverthepastfewdecades.Astheeraofnext-generationsequencingandpersonalizedtreatmentforcancerapproaches,LSCCmaybeanidealdiseaseforconsiderationoffurthertreatmentstratificationandpersonalization.Here,wewilldiscusstheimportanthistoryofLSCCasamodelsystemfororganpreservation,uniqueandpotentiallytargetablegeneticsignaturesofLSCC,andmethodsforbringingstratified,personalizedtreatmentstrategiestothe21~(st)century.

简介：Wedescribeanoveltechnique,lowsurfaceenergyGasExpansionMolding(GEM),tofabricatemicrobubblearraysinpolydimethylsiloxane(PDMS)whichareincorporatedintoparallelplateflowchambersandtestedincellsortingandmicrocellcultureapplications.Thisarchitectureconfersseveraloperationaladvantagesthatdistinguishthistechnologyapproachfromcurrentlyusedmethods.HereinwedescribetheGEMprocessandtheparametersthatareusedtocontrolmicrobubbleformationandaVacuum-AssistedCoating(VAC)processdevelopedtoselectivelyandspatiallyalterthePDMSsurfacechemistryinthewellsandonthemicrochannelsurface.WedescriberesultsfrommicroflowimagevisualizationstudiesconductedtoinvestigatefluidstreamsaboveandwithinmicrobubblewellsandconcludewithadiscussionofcellculturestudiesinPDMS.

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简介：MicroRNAs(miRNAs)内长的、小、非编码的RNA，它能够在post-transcriptional的silencing基因表示铺平。在这研究，我们报导miR-205是显著地在与匹配的正常的胸织物相比的胸肿瘤的underexpressed。同样，包括MCF-7和MDA-MB-231，乳癌房间行比非恶意的MCF-10A房间表示低级miR-205。兴趣，miR-205的宫外的表示显著地禁止房间增长和抛锚独立人士生长，以及房间侵略。而且，miR-205被显示在一个动物模型压制肺转移。最后，西方的污点与试金表明的酶记者结合了那ErbB3和脉管的endothelial生长因素A(VEGF--一)是为miR-205的直接目标，并且这miR-205-mediated抑制通过和在ErbB3和VEGF的3鈥?untranslated区域(3鈥?UTR)的通常认为的miR-205绑定地点的直接相互作用是可能的--一。一起，这些结果建议miR-205是在乳癌的肿瘤suppressor。

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简介：治疗学的克隆，胚胎的干细胞(转换字符)由此从原子转移(NT)被导出胚胎，可以在再生药的新时代起一个主要作用。Inthis学习我们建立了四十原子转移--从不同施主房间类型或段落的NTembryos被导出的转换字符(NT转换字符)线。我们发现NT转换字符能够形成胚胎植物或动物身体。另外，NT转换字符表示了pluripotency干细胞标记试管内并且能区分进胚胎的纸巾体内。从施主房间能形成完整的术语的早经过R1的NT胚胎开发了小狗，而那些为为实时出生是必要的reprogramming从迟了的经过R1ES施主房间失去了潜力。我们随后建立了近来从NT胚囊被开发的sequentialNT-R1-ESC线经过R1转换字符施主。然而，当在他们的早段落用作原子转移施主时，这些NT-R1-ESC排队，没能导致实时小狗。这显示用顺序的NT转换字符的治疗学的克隆过程不能救居住在以前的施主代的发展缺乏。

简介：Theelectricallyevokedsomaticmotilityofouterhaircells(OHC),brieflytermedOHCelectromotility,playsacrucialroleincochlearamplificationthatunderliestheremarkablyhighsensitivityandfrequencyselectivityofthemammalianhearing.AccompanyingOHCelectromotilityisavoltage-dependentgatingchargemovementwithinthecelllateralmembrane,manifestedasameasurablenonlinearcapacitance(NLC)inOHCs.TheelectromotilityandNLCofOHCsarehighlycorrelatedbysharingacommonmolecularsubstrate,themotorproteinprestin.Inthisstudy,wesystematicallycharacterizedthequantitativerelationshipbetweenOHCelectromotilityandNLCintheirvoltagedependencesforthepurposeoffurtherunderstandingtheelectromechanicaltransductioninOHCs.TheresultsdemonstratedthatthetwopossessdifferingvoltagedependenceswiththeV1/2ofelectromotilityconsistentlybeing～20mVdepolarizedincomparisonwiththatofNLCalthoughtheirslopefactorsαarestatisticallyidentical.FurtherinvestigationsshowedthattheinitialstateofOHCsinfluencesthevoltagedependenceofelectromotilitybutnotthatofNLC,indicatingthatsomebiophysicalfactorsotherthanthemotorproteinperseareinvolvedintheprocessofOHClengthchanges.Weproposedthatthecytoskeletalspectrin-actinframeworkunderneaththeOHCplasmamembraneandthecell'sturgorarethetwomostprobablefactorsthatcausethevoltage-dependencediscrepancybetweenOHCelectromotilityandNLC.

简介：Allexistingprotonexchangemembrane(PEM)fuelcellgasflowfieldshavebeendesignedonthebasisofsingle-phasegasflowdistribution.Thepresenceofliquidwaterintheflowcausesnon-uniformgasdistribution,leadingtopoorcellperformance.Thispaperdemonstratesthatagasflowrestrictor/distributor,asiscommonlyusedintwo-phaseflowtostabilizemultiphasetransportlinesandmultiphasereactors,canimprovethegasflowdistributionbysignificantlyreducinggasmal-distributioncausedbyeithernon-uniformwaterformationinparallelflowchannelsorflowinstabilityassociatedwithnegative-slopepressuredropcharacteristicoftwo-phasehorizontalflowsystems.

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简介：Spindlecellcarcinomaofthebreastisararetumor.Thistumorcanproliferaterapidlyandcausecysticchangesbecauseofinternaltissuenecrosis.Weevaluateda54-year-oldwomanwithrightbreastlump.Mammographyshowedacategoryfourmasswithadiameterof2.5cm.Ultrasonography(US)revealedacomplexcysticlesion,andfine-needleaspiration(FNA)cytologydemonstratedbloodyfluidandmalignantcells.Partialbreastresectionandsentinellymphnodebiopsywereperformed.Immunohistologyrevealedspindlecellswithpositiveresultsforcytokeratin(AE1/AE3)andvimentin,partiallypositiveresultsfors-100,andnegativeresultsfordesminandα-actin.ThepathologicalstagewasIIA,andbiochemicalcharacterizationshowedthatthetumorwastriplenegative.SixcoursesofFEC-100chemotherapy(5-fluorouracil500mg/m2,epirubicin100mg/m2,andcyclophosphamide500mg/m2)wereadministered.Radiotherapywasperformed.Thiscaseisdiscussedwithreferencetotheliterature.

简介：Objective:Thisstudyaimstoinvestigatethetruth-tellingstatusandtherelevantfactorsofesophagealsquamouscellcarcinoma(ESCC)patientsinHenan,China.Methods:Across-sectionalstudyfromApriltoJune2015usingquestionnaireswasgivento301familymembersofhospitalizedESCCpatientsbasedinthreeaffiliatedhospitalsofZhengzhouUniversity(i.e.,TheFirstHospital,TheSecondHospital,andTumorHospital)andAnyangTumorHospital.Results:Amongthe41.9%(126/301)hospitalizedESCCpatientswhoknewoftheirtruediagnoses,only4.0%patientswereinformedbytheircorrespondingresponsibledoctors,39.7%bytheirfamilymembers,and56.3%bythemselves.UnivariateanalysesshowedthatdisclosureofconfirmedESCCdiagnosistopatientswascorrelatedwithgender,familyhistoryofcancer(FHC),educationlevel,vocation,hospitaladministrativelevel,andattitudesoffamilymembers(P<0.05).Furthermore,multivariateanalysisindicatedthatattitudeoffamilymemberswasthemostimportantandanindependentfactorfordiagnosisdisclosure.ThosepatientswithanegativeFHC,under-education,manualoccupation,advancedstages,andhospitalizedinmunicipalhospitalsexhibitedalowrateoftruthtelling.Conclusions:TruthtellingforESCCpatientsinHenanisnotprevalentandmaybeimprovedthroughconsultationwithfamilymembers,particularlyforpatientswithanegativeFHC,pooreducation,manualoccupation,andadvancedstages.

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简介：免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而，内在的机制需要充分被调查为癌症chemoimmunotherapy指导更有效的协议的设计。联系危险的分子的模式(阻尼)能激活有免疫力的房间，是众所周知的，包括树枝状的房间(DC)，经由像使用费的受体(TLR)；然而，在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里，我们发现那colorectal与oxaliplatin(OXA)对待的癌症(CRC)房间或5氟尿嘧啶(5-Fu)释放了高活动性的组盒子1的高水平(HMGB1)和热吃惊蛋白质70(HSP70)。在OXA/5-Fu治疗以后，也展出的CRC病人的sera增加了HMGB1和HSP70的层次，哪个是著名阻尼。与OXA/5-Fu对待的垂死的CRC房间的上层清液支持了老鼠和人的DC成熟，与HLA医生，CD80和CD86表示和IL-1β的改进的upregulation；，TNF-α；，MIP-1α；，MIP-1β；，RANTES和IP-10生产。由DC组成的疫苗与导致的化学上强调的CRC房间的上层清液搏动了更重要的IFN-γ；在vitro并且在vivo生产Th1反应。然而，化学上强调的CRC房间的上层清液没能在TLR4缺乏的DC导致phenotypic成熟和cytokine生产，显示在导致阻尼的DC成熟和激活的TLR4的一个必要角色。而且，有化学上强调的CRC房间的上层清液的pulsing高效地没导致IFN-γ；在TLR4缺乏的DC生产Th1反应。一起，这些结果证明免除化学上强调的癌症房间的阻尼能经由TLR4激活DC并且提高反肿瘤T房间有免疫力的回答的正式就职，描出一条临床上相关的免疫助手小径由阻尼被触发。

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