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简介：ThispaperaimstopresentanexperimentdevelopedinatechnologydegreecollegeinS?oPaulo:thefreshmenintegrationandremedialclassesweek.Thisworkwasdevelopedduetothedropoutratethatoccurredinseveralcourses.The50%dropoutratewascollectedthroughasampleofthefirstsemesterfrom2012to2014.Thiscollegehascoursesinweldingtechnology,mechanicalmanufacturing,industrialautomationandrefrigeration,airconditioning,andventilationandheating.Itisapubliccollege.Astheyarecoursesoftheareaofmechanicalengineering,theirfirstsemestersconsistofcalculus,physics,chemistry,statistics,andotherdisciplinesthatrequiresolidknowledgebackgroundfromseniorhighschool.Thisisnottherealityfortheprofileofincomingstudents.Ninety-fivepercentofthestudentscomefrompublicschools.Remedialclassesweekiscomprisedofremedialclassesonmathematics,motivationallectures,presentationoftheacademic,andjobmarketarea,aswellasintegrationwithveteranstudents,teachers,andcoordinators.Thisworkbeganin2014andtherewas35%evasionreduction.

简介：Chinahaspublishedastricteremissionstandardforthermalpowerplantsinordertohelpreducethepowerindustry'ssulfurdioxideemissionsbyoversixmillio

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简介：Anesthesiaisanimportantpartofmedicine:theabilitytopreventpainand/orunwantedmovementduringsurgeryiscriticaltomakingtherequiredincisionsandinjectionsortoemployotherpotentiallypainfulprocedureswithoutcausingthepatientunduedistress.Patientswithchronicpain,especiallythosewithneuralgia(amalfunctioningnervethatconstantlysignalspain),alsorelyon

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简介：一个热电源系统的效率能被电产生和电消费的操作的工艺的前进改进，这广泛地被认出了。聪明的米启用在顾客和电产生系统之间的双向通讯。电产生系统使用价格刺激(即在高峰时期的更高的价格和在离峰的时期的更低的价格)在聪明的格子环境下面从山峰转移要求的部分到离峰的时期。给在每个时期的那燃料消费是严格地增加的事实电源输出的凸的功能，我们求婚二时期并且多时期定价策略，和研究减少燃料消费上的不同定价策略的效果。

简介：Itisestimatedthatmorethanonemillionheartfailurehospitalizationsoccureachyear.Systolicheartfailureandheartfailurewithpreservedejectionfractioncontributeequallytoheartfailurehospitalizations.Heartfailurereadmissionratescontinuetobeabout25%.Strategiestoreduceheartfailurereadmissionarekeytoreducinghospitalizationrates.Thestrategiestoreduceheartfailurehospitalizationareasfollows:(1)Duringhospitalization,diuresistotheeuvolemicstateisessential.Fiftypercentofdischargedheartfailurepatientshaveminimalweightlossduringthehospitalization,representingminimaldiuresis,butstillfluidoverload.(2)Duringhospitalization,interrogatethedefibrillatororbiventricularpacemaker(ifapplicable)toensurethatthereisnorightventricularpacingandthereisappropriatebiventricularpacing.Interrogationofdevicescanidentifyarrhythmiaorsuboptimalbiventricularpacing,whichcancontributetodecompensation.(3)Beforedischarge,identifythereasonfordecompensation,suchasatrialfibrillation,infection,pulmonaryembolism,ornoncompliance.(4)Beforedischargeamultidisciplinaryteamisneededtoeducatethepatientondiet,medications,fluidweightsurveillance,andexercise.(5)Apostdischargevisitshouldoccurwithin10daysandwithemphasisonuptitrationofneurohormonalblockersandcontinuedcongestionmanagement.Suchinterventionsconductedbyamultidisciplinaryteamhavethepotentialtoreduceheartfailurehospitalizationrates.

简介：Background:Apreviousstudyhasreporteda50%reductionindisuseatrophyofthequadricepsduringthefirst14daysafteranteriorcruciateligament(ACL)reconstruction.Afollow-uptrialisneededtoconfirmthesepromisingresults.ThepresentstudyaimstoinvestigatetheeffectofanocclusionstimulusonquadricepsatrophyafterACLreconstruction.Methods:Atotalof24subjectsparticipatedinthestudy.Theywererandomizedintotwogroups.Startingthe2nddayaftersurgery,theocclusiongroupreceivedanocclusionstimulusfor5min,followedbyremovaloftheocclusivepressurefor3min.Thiswasrepeatedfivetimesinonetrainingsession,twicedaily.Duringtheperiodofocclusivestimulus,thesubjectsperformed20lowloadexercisesforthequadriceps.Thecontrolgroupfollowedthesameexerciseprotocol,butwithouttheocclusionstimulus.Changesinquadricepsanatomicalcrosssectionarea(ACSA)weremeasuredusingaxialmagneticresonance(MR)imagesat40%and50%ofthelengthofthefemur.Results:BothgroupshadasignificantreductionofquadricepsACSAfrom2daysbeforesurgeryto16daysaftersurgery.Duringtheinterventionperiod,theocclusiongrouplost13.8%±1.1%(mean±SEM)andthecontrolgrouplost13.1%±1.0%oftheirquadricepsACSA,respectively.Therewasnosignificantdifferencebetweentheocclusionandcontrolgroupswithregardstoatrophyofthequadricepsmuscles.Conclusion:Inconflictwithotherstudiesusingasimilarprotocol,applicationofbloodflowrestrictionthefirst14daysafterACLreconstructiondidnotreducequadricepsACSAmuscleatrophymeasuredbyMRinapopulationofathletes.

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简介：Outdoorairpollutionisaknownriskfactorformortalityandmorbidity.Thetypeofairpollutantmostreliablyassociatedwithdiseaseisparticulatematter(PM),especiallyfinerparticulatematterthatcanreachdeeperintothelungslikePM_(2.5)(particulatematterdiameter<2.5μm).SomesubpopulationsmaybeparticularlyvulnerabletoPMpollution.Thisreviewfocusesononesubgroup,long-termstrokesurvivors,andtheemergingevidencesuggestingthatsurvivorsofastrokemaybeatahigherriskfromthedeleteriouseffectsofPMpollution.Whilethemechanismsformortalityarestillunderdebate,long-termstrokesurvivorsmaybevulnerabletosimilarmechanismsthatunderliethewell-establishedassociationbetweenPMpollutionandcardiovasculardisease.Thefactthatlong-termstrokesurvivorsofischemic,butnothemorrhagic,strokesappeartobemorevulnerabletotheriskofdeathfromhigherPMpollutionmayalsobolstertheconnectiontoischemicheartdisease.SurvivorsofanischemicstrokemaybemorevulnerabletodyingfromhigherconcentrationsofPMpollutionthanthegeneralpopulation.TheclinicalimplicationsofthisassociationsuggestthatreducedexposuretoPMpollutionmayresultinfewerdeathsamongststrokesurvivors.

简介：Apeer-to-peer(P2P)networkisadistributedapplicationarchitecturewhichprovidesmanyattractivefeatures,suchasavailability,self-organization,load-balancing,andanonymity.However,P2Pnetworkhascreatedsignificantproblemstonetworkoperatorsbygeneratinglargevolumesofinterautonomoussystem(inter-AS)traffic.FocusingontheBitTorrentswarmingprotocol,thispaperproposesanapproachwhichaimstoreduceP2Pgeneratedinter-AStraffic.Inparticular,theapproachcanreduceinter-AStrafficby50%to70%.Moreover,itcanimprovethedownloadingspeedby60%forthepopulartorrents.Theevaluationshowsthatcontrolledregional-basedcontentsreplicationcaneffectivelyachievethisgoal.Furthermore,theapproachisincrementallydeployable.NetworkregionsinwhichthesystemgetsdeployedcansolvetheirP2Pgeneratedinter-AStrafficproblemsautonomously,i.e.,withoutanyInternetserviceproviders-collaborationandanyrequirement,thesystemcanbedeployedintheentireInternet.

简介：BACKGROUND:GenetherapyforParkinson'sdiseaseisbeingexploredasaneffectivestrategytorestoreandprotectthefunctionofneuronalcellsinthesubstantianigra.Regulationofgeneexpressionisnecessaryforgenetherapytoavoidadverseeffectsduetoexcessivesynthesisoftransgeneproducts.OBJECTIVE:Herewedevelopedrecombinantadeno-associatedvirus(AAV)asaviralvector-mediatedgeneregulationsystembasedonCrerecombinasefusedtothemutatedligand-bindingdomainoftheestrogenreceptor(CreERT2)+inducingagenttamoxifen.InducibleCrerecombinasewasusedtoreducetyrosinehydroxylasegeneexpressionandtopreventtheexcessiveincreaseindopamine.DESIGN,TIMEANDSETTING:Ageneticengineeringinvitrocomparativestudyandrandomizedcontrolledanimalexperiment.ThisstudywasconductedattheGeneTherapyCenter,JichiMedicalSchool,JapanfromJune2002toJune2004.METHODS:ToconstructarecombinantAAVvectorcarryingadopaminesynthasegene.ThetyrosinehydroxylasegenewasinsertedusingaloxPfragmentthatcouldberegulatedbyCrerecombinase.TherecombinantAAVvectorcarryingtheCreERT2genewasco-transducedwithHEK293cellsandthecorpusstriatuminaratmodelofParkinson'sdisease,withinducingagenttamoxifentoregulategeneexpression.MAINOUTCOMEMEASURES:ThelevelsofdopamineandaromaticL-aminoaciddecarboxylase(AADC)activityweredetectedinHEK293cellmediumandinthecorpusstriatuminaratmodelofParkinson'sdiseaseusinghigh-performanceliquidchromatography.ImmunofluorescencedoublestainingwasusedtoobservetyrosinehydroxylaseandCreorAADCco-expressioninHEK293cellmedium.ImmunohistochemicalstainingwasemployedtoobservetyrosinehydroxylaseandAADCexpressionandbehavioralchangesweremeasuredinParkinson'srats.RESULTS:TransfectedAAV-CreERT2andAAVexpressingdopaminesynthesisenzymescouldincreasethesynthesisofdopamineinHEK293mediumandParkinson'sratstriatum(P<0.01)andimprovetherotationalbehaviorofParkin

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简介：近几年来,Skyline查询处理在许多应用领域具有潜在的实用价值。在Map-Reduce框架下采用基于角度数据划分的方法,本文提出Cirl-Skyline查询算法。进一步提高算法的查询效率,为了更好的解决重复计算局部没有发生变化Skyline查询点的问题,在Cirl-Skyline算法的基础上提出Restrict-Skyline算法。理论分析和实验证实,该算法具有高效性和可扩展性。