简介：抽象昆虫由被不变的微生物引起的表面分子的识别激活的一个有效天生的免疫系统保护自己免于微生物引起的感染。在水果苍蝇果蝇melanogaster，细菌的存在在主人与抗菌剂肽的表示被联系免疫者能干的纸巾。主人受体检测感染并且中继信号装适当有免疫力的反应。在果蝇像血球的l(2)有Pefabloc的mbn房间感染前处理，一个通常使用的丝氨酸朊酶禁止者，导致了二主要效果：它响应现场克否定的细菌和细菌的表面分子(peptidoglycans污染的粗略的lipopolysaccharide)堵住了抗菌剂肽Diptericin的表示，它导致了词法变化。

简介：与朊酶的高产量的酵母紧张10在Qingdao附近从盐场的沉积被孤立，中国。朊酶在氢指数举办了最高的活动9.0和45℃。紧张10的最大的碱的朊酶生产的最佳的媒介是2.5g在有起始的氢指数的100mL海水的可溶的淀粉和2.0gNaNO_36.0。为最大的朊酶生产的最佳的耕作条件是温度24.5℃，通风率8.0Lmin~(-1)和焦虑速度150rmin~(-1)。在最佳的条件下面，623.1Umg~(碱的朊酶的-1)蛋白质在发酵的30h以内在文化被到达。

简介：Thetitlecompoundchlorpropham(CASnumber:101-21-3,C10H12ClNO2,Mr=213.66)waspreparedbytheadditionreactionof3-chlorophenylisocyanatewithisopropanol.Spectraldata,IR,NMRandMS,werereported.ThispaperprovidessomerelatedinformationaboutRegulatoryStatus,ToxicologicalEffects,EcologicalEffectsandEnvironmentalFatealso.

简介：Ameloblastomaisabenignbutlocallyaggressiveodontogenieneoplasmthataccountsfor10%ofalltumorsarisinginthemandibleandmaxilla(1).Eightypercentofameloblastomasariseinthemandible,andtheyareusuallyfoundinyoungadults.Itfrequentlyrecursifnotadequatelyresected.Therefore,thestandardtherapyforthistumoriscompleteboneresectionwithanadequatemarginofsafety:marginalorsegmentalosteotomy.However,aestheticdeformities,functionalimpairmentsandpsychologicalimpairmentsafterradicalsurgeryforlargeameloblastoma,havebeenseriousissues(1).

简介：Apotentialdualinhibitor(4)forexogenousabsorptionandendogenicsynthesisofcholesterolwasdesignedbasedontheconjugationoftheβ-lactampharmacophoreofezetimibeandtheδ-lactonepharmacophoreofstatins.Themergerofezetimibeandstatin4wassynthesizedfromp-hydroxybenzaldehydethroughaten-steproute.1HNMRanalysisshowedexistenceoffourpairsofenantiomers(5.7:5.7:1:1,molarratio).Andcompound4wasfoundtolowertotalglucose(TG)levelinratserumviaahigh-cholesterolandhigh-fatfeedingexperiment.

简介：Objective:ToinvestigatetheeffectsofE7080andN5-(1-iminoethyl)-L-ornithinedihydrochloride(L-NIO)oncolorectalcanceraloneandincombination.Methods:HT29colorectalcancercelllinefromSapInstitutewasused.Real-timecellanalysis(xCELLigencesystem)wasperformedtodeterminetheeffectsofE7080andL-NIOoncolorectalcellproliferation.WhileapoptosiswasdeterminedwithAnnexinVstaining,andtheeffectofagentsonangiogenesiswasdeterminedwithchorioallantoicmembrane(CAM)model.Results:WefoundthatE7080hasastrongantiproliferativeeffectwithanhalfmaximuminhibitionofconcentration(IC50)valueof5.60×10–8mol/L.AlsoithasbeenobservedthatE7080showedantiangiogenicandapoptoticeffectsonHT29colorectalcancercells.AntiangiogenicscoresofE7080were1.2,1.0and0.6for100,10and1nmol/LE7080concentrations,respectively.Furthermore,apoptosishasbeendetectedin71%ofHT29colorectalcancercellsafteradministrationof100nmol/LE7080whichmayindicatestrongapoptoticeffect.MeanwhileadministrationofL-NIOalonedidnotshowanyeffect,butthecombinationofE7080withL-NIOincreasedtheantiproliferative,antiangiogenicandapoptoticeffectsofE7080.Conclusions:ResultsofthisstudyindicatethatE7080maybeagoodchoiceintreatmentofcolorectaltumors.FurthermoretheincreasedeffectsofE7080whencombinedwithL-NIOraisethepossibilitytousealowerdoseofE7080andthereforeavoid/minimizethesideeffectsobservedwithE7080.

简介：AIM:Toinvestigatetheabilityofproteaseinhibitorstomodulatehistaminereleasefromhumancolonmastcells.METHODS:Enzymaticallydispersedcellsfromhumancolonwerechallengedwithanti-IgEorcalciumionophoreA23187intheabsenceorpresenceoftryptaseandchymaseinhibitors,andhistaminereleasewasdetermined.RESULTS:IgEdependenthistaminereleasefromcolonmastceilswasinhibitedbyuptoapproximately37%,26%and36.8%bychymaseinhibitorsZ-Ile-Glu-Pro-Phe-CO2Me(ZIGPFM),N-TosyI-L-phenylalanyl-chloromethylketone(TPCK),andC~l-antitrypsin,respectively.Similarly,inhibitorsoftryptaseleupeptin,N-tosyI-L-lysinechloromethylketone(TLCK),lactoferrinandprotaminewerealsoabletoinhibitanti-IgEinducedhistaminereleasebyamaximumofsome48%,37%,40%and34%,respectively.Preincubationoftheseinhibitorswithcellsfor20rainbeforechallengedwithanti-IgEhadsmalleffectontheinhibitoryactionsoftheseinhibitorsoncolonmastcells.Aspecificinhibitorofaminopeptidaseamastatinhadnoeffectonanti-IgEinducedhistaminerelease.Thesignificantinhibitionofcalciumionophoreinducedhistaminereleasewasalsoobservedwiththeinhibitorsoftryptaseandchymaseexamined.Apartfromleupeptinandprotamine,theinhibitorstestedbythemselvesdidnotstimulatecolonmastcells.CONCLUSION:ItwasdemonstratedthatbothtryptaseandchymaseinhibitorscouldinhibitIgEdependentandcalciumionophoreinducedhistaminereleasefromdispersedcolonmastcellsinaconcentrationdependentofmanner,whichsuggestthattheyarelikelytobedevelopedasanovelclassofanti-inflammatorydrugstotreatchronicofcolitisinman.

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简介：ＢＯＵＮＤＥＤＮＥＳＳＡＮＤＢＬＯＷＵＰＦＯＲＴＨＥＧＥＮＥＲＡＬＡＣＴＩＶＡＴＯＲ－ＩＮＨＩＢＩＴＯＲＭＯＤＥＬＬｉＭＩＮＧＤＥ（李名德）；ＣＨＥＮＳＨＡＯＨＵＡ（陈绍华）；ＱＩＮＹＵＣＨＵＮ（秦禹春）（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃ...

简介：TheethanecrackeratasteamcrackerofYangziPetrochemicalCompany(YPC)hasbeensafelyoperatingformorethan100dayssinceapplicationofdomesticN360cokeinhibitorstartingAugust28,2004tosetanewrecordontheoperatingcycleofethanecracker,whichhasrevealedgreatsuccessincommercialapplicationofthisinhibitor.

简介：Cisplatindamagescochlearhaircellsandspiralganglionneuronsthroughcelldeathsignalingpathwaysthatarenotfullyunderstood.Weusedfocusedapoptosisgenemicroarraystostudyearlychangesingeneexpres-sionincochlearculturesfromP3neonatalratstreatedwithcisplatin(0.2mM).After12hoursofcisplatintreat-ment,morethan50%ofthe96genesonthearrayshowedasignificantdecreaseinexpression,consistentwithwidespreadcelldeath.However,after3hoursofcisplatintreatment,10genesshowedsignificantincreaseinex-pressionintotalcochleartissue.Inexperimentswithsubsetsofcochleartissues,at3h,cisplatininducedincreasedexpressionof12genesinthecochlearsensoryepithelium(basilarmembrane)and11genesinthespiralganglion(tissueofRosenthal'scanal,containingthespiralganglion).Theseincludedpro-andanti-apoptoticgenesin-volvedinthep53signalingpathway,TNFreceptorfamily,NF-kappaBpathway,deathdomainfamily,deatheffec-tordomainfamily,Bcl-2family,CARDfamily,TRAFfamily,andGTPsignaltransduction.Althoughthechangesingeneexpressionshowedanoverlapbetweenbasilarmembraneandspiralganglion,otherchanges,whichmayreflecttheuniqueresponseofeachtissue,werealsoobserved.Pifithrin-αblockedcisplatin-inducedup-regulationofgenesinthep53signalingpathwaywhenassayedbybothsuperarrayandrealtimePCR.Thedataaddtoourunderstandingoftheinvolvementofp53incisplatin-inducedototoxicityandotoprotection,conferredbythep53inhibitorPifithrin-α.

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简介：ObjectiveThisstudywasinitiallydesignedtoevaluatetheeffectofcelecoxibontheregimenof5-fluorouracil,epirubicin,andcyclophosphamide(FEC)combination,followedbydocetaxel(T)inneoadjuvantsetting.AnunplannedpreliminaryreviewonsafetywasconductedafterahaltofthestudyduetotheconcernedpotentialcardiovascularriskofusingCOX-2inhibitors.MethodsWestudied23consecutivecasesofoperablebreastcancerhavingreceivedfourcyclesofFEC(500mg/m2,100mg/m2,500mg/m2)followedbyfourcyclesofT(100mg/m2)withconcurrentcelecoxib(400mgtwicedaily)(groupA)orsamechemotherapyregimenbutwithoutconcurrentcelecoxib(groupB).Thesecombinedchemotherapieswereadministeredevery3weeks.TheChi-squaretestorFisher'sexacttestwereusedtoassessthedifferenceinincidenceoflimitinghematologicaltoxicitesbetweengroups.Results23patients(groupA:n=12;groupB,n=11)receivedatotalof183outof184plannedtreatmentcycles;one(4%,1/23)ofthemomittedthefourthcycleofFECowingtorepeatedincidencesoffebrileneutropenia.Receiveddoseintensity(RDI)forFECingroupA(90%±11%)washigherthanthatingroupB(80%±8%)whileRDIforTwassimilarbetweengroupA(93%±8%)andgroupB(96%±9%).Ofthefirst91treatmentcyclesofFEC,limitinghematologicaltoxicity,severeneutropeniaincludingfebrileneutropenia,wassignificantlydifferentbetweengroupAandB[(10.4%,5/48)vs.(32.6%,14/43),P=0.009].Othertoxicitiescommonlyobservedinchemotherapyreceivingpatientsweremanageable.ConclusionsNeoadjuvantuseofFECfollowedbyTwithconcurrentcelecoxibappearedtobesafefortreatmentofoperableinvasivebreastcancer.Theobservedlowerincidenceofchemotherapy-inducedneutropeniaispossiblycontributedbytheadministrationofCOX-inhibitor.WebelievethatfurtherinvestigationmightprovidemoreevidenceontheuseofCOX-2inhibitorsinbreastcancer.

简介：XADisanapoptosisspecificDNaseinXenopusandcancutthelinker-DNAbetweennucleosomesduringapoptosisinXenopuslaeviseggextractinducedbycytochromec.XADismostlikelytobethehomologuetoDFF40inhumans.TheactivityofDFF40canbeinhibitedbyDFF45.WereportmolecularcloningandidentificationofanXADinhibitor,IXAD(inhibitorofXAD),inXenopuseggs.WeclonedthecompletecDNAoftheDFF45homologue,IXAD.ThereisaspecificDEVDsequenceinitsN-terminal,whichserves

简介：我学习的最近的阶段报导了单个代理人的活动poly(自动数据处理核糖)聚合酶(PARP)禁止者在分散并且在BRCA变异的前列腺癌症。在前列腺癌症，et基因重新整理和PTEN的损失的二最普通的基因改变，在现出症状之前的潜的模型被连接了到增加的敏感到PARP禁止者。新兴的证据也建议PARP1在调停起一个重要作用雄激素受体(AR)和et基因重新整理的transcriptional活动。在这篇文章，在为变形前列腺癌症作为一个新治疗范例开发PARP基于禁止者的治疗的现出症状之前的潜的工作和早阶段的临床的审判被考察。

简介：有对Helicoverpaarmigera的内脏朊酶的活动的一个Bowman-Birk禁止者从Albizialebbeck的使脱去脂肪的种子面粉在0.1M钠磷酸盐缓冲区被提取。它在DEAE-SephadexA50上用铵硫酸盐降水，SephadexG-100列上的胶化过滤层析和离子交换层析与51.43%恢复被净化到29.62褶层。净化的蛋白质有由SDS页决定了的12,303daltons的分子的重量。是热被发现稳定直到60

简介：<正>Nowtheminingofhighsaltundergroundbrinehasbeenanimportantaspectofsaltlakemining,whichisthenecessarysupporttothedevelopmentofnationaleconomy.Withthechangeofundergroundgeological

简介：Inthispaper,theeffectofaddingdifferentconcentrationsofkineticinhibitorsontheinductiontimeofhydrogensulfidehydrateformationinareactorequippedwithautomaticadjustabletemperaturecontrollerisstudied.Anovelmethodnamely"suddencooling"isusedforperformingtherelevantmeasurements,inwhichtheinductiontimeofH2Shydrateinthepresence/absenceofPVPandL-tyrosinewithdifferentconcentrations(100,500,and1000ppm)isdetermined.Asaresult,PVPwiththeconcentrationof1000ppminaqueoussolutionisdetectedasamoresuitablematerialforincreasingtheinductiontimeofH2Shydrateformationamongtheinvestigatedkinetichydrateinhibitors.

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简介：ObjectiveToinvestigatetheeffectsofselectivenitricoxidesynthase(NOS)inhibitorsondentategyrusneurogenesisafterdiffusebraininjury(DBI)intheadultratbrain.MethodsAdultmaleSDratsweresubjectedtodiffusebraininjury(DBI)model.Byusingsystemicbromodeoxyuridine(BrdU)tolabeldividingcells,wecomparedtheproliferationrateof