简介：加拿大更新ADHD治疗药说明书，加拿大警告雷洛昔芬导致中风风险升高，加拿大限制吉非替尼的使用，加拿大警告治疗勃起功能障碍药品的安全性，加拿大建议心脏病患者慎用含L-精氨酸的产品，美国FDA警告抗抑郁药给孕妇带来的风险……

简介：纳米科技是20世纪80年代末90年代初兴起的涉及多学科的高新科学和技术。纳米是一个尺寸大小的度量单位，一纳米等于十亿分之一米。纳米技术是指在1—100纳米这一尺度范围内对原子、分子进行操纵和加工的技术，包括纳米结构和纳米材料。

简介：这里所述的“纳米”(nm)的“纳”字原是希腊文中“矮小”的意思。纳米实际上是一种计量单位，1纳米是1米的十亿分之一，相当于10个氢原子一个挨一个排起来的长度，人一根头发丝的直径相当于6万个纳米。形象地讲，一纳米的物体放到乒乓球上，就像一个乒乓球放在地球上一般。这就是纳米长度的概念。

简介：在纽约,1996年研究者发现人群中有些人对艾滋病有天生的抵抗能力,因为他们缺少一种由父母双方各提供一个的叫做CCR5的基因的两个复制品。在免疫系统的细胞上发现了CCR5的受体。如果具有一个CCR5基因复制品的个体转化为HIV病毒感染者,再发展成AIDS所需的时间可能较其他人

简介：Changesinneurocognitivefunctioningandqualityoflifeinadultpatientswithbraintumorstreatedwithradiotherapy.

简介：PURPOSE：Vorinostat,ahistonedeacetylaseinhibitor,representsarationaltherapeutictargetinglioblastomamultiforme（GBM）.PATIENTSANDMETHODS：PatientswithrecurrentGBMwhohadreceivedoneorfewerchemotherapyregimensforprogressivediseasewereeligible.

简介：Markedresponseofgliomatosiscerebritotemozolomideandwholebrainradiotherapy.

简介：PURPOSE：ResistancetotemozolomidechemotherapyispartlymediatedbyO^6-methylguanine-DNAmethlytransferase（MGMT）.ProtractedtreatmentwithtemozolomidepotentiallyovercomesMGMTresistanceandimprovesoutcome.WeconductedaphaseIIstudyofprotracteddailytemozolomideinadultswithlow-gradegliomas.EXPERIMENTALDESIGN：PatientswithnewlydiagnosedoligodendrogliomaoroligoastrocytomawithaMIB-1indexof〉5%orrecurrentlow-gradegliomasreceivedtemozolomide（75mg/m^2/dayin11-weekcyclesof7weekson/4weeksoff）.Treatmentcontinuedforatotalofsixcyclesoruntiltumorprogressionorunacceptabletoxicity.Primaryendpointwasbestoverallresponserate;secondaryendpointswereprogression-freesurvival,overallsurvival,andtoxicity.

简介：BACKGROUND：In2004,arandomisedphaseⅢtrialbytheEuropeanOrganisationforResearchandTreatmentofCancer（EORTC）andNationalCancerInstituteofCanadaClinicalTrialsGroup（NCIC）reportedimprovedmedianand2-yearsurvivalforpatientswithglioblastomatreatedwithconcomitantandadjuvanttemozolomideandradiotherapy.We＇reportthefinalresultswithamedianfollow-upofmorethan5years.METHODS：Adultpatientswithnewlydiagnosedglioblastomawererandomlyassignedtoreceiveeitherstandardradiotherapyoridenticalradiotherapywithconcomitanttemozolomidefollowedbyuptosixcyclesofadjuvanttemozolomide.

简介：Monochromaticminibeamsradiotherapy：fromhealthytissue-sparingeffectstudiestowardfirstexperimentalgliomabearingratstherapy.

简介：PURPOSE：Toevaluatethetoxicityandresponserateofbortezomibwithconcurrentradiotherapyandtemozolomideinthetreatmentofpatientswithcentralnervoussystemmalignancies.PATIENTSANDMETHODS：Thisopen-label,dose-escalation,PhaseⅠclinicalstudyevaluatedthesafetyofthreedoselevelsofintravenouslyadministeredbortezomib（0.7,1.0,and1.3mg/m（2）/dose）onDays1,4,8,and11ofa21-daycycle,inadditiontoconcurrentradiotherapyandtemozolomideatadailydoseof75mg/m（2）startingonDay1.Theprimaryendpointwasdose-limitingtoxicity,definedasanyGrade4-5toxicityorGrade3toxicitydirectlyat-tr/butabletoprotocoltreatment,requiringhospitalizationand/orradiotherapyinterruption.

简介：PURPOSE：ThisphaseⅡtrialwasdesignedtodefinetheroleofO^6-benzylguanine（O^6-BG）inrestoringtemozolomidesensitivityinpatientswithrecurrentorprogressive,temozolomidc-resistantmalignantgliomaandtoevaluatethesafetyofadministeringO^6-BGincombinationwithtemozolomide.PATIENTSANDMETHODS：Patientswereaccruedintotwoindependentstrataonthebasisofhistology：glioblastomamultifonne（GBM）andaanaplasticglioma.BothtemozolomideandO6-BGwereadministeredonday1ofa28-daytreatmentcycle.Patientswereadministereda1-hourO^6-BGinfusionatadoseof120mg/m^2followedimmediatelybya48-hourinfusionatadoseof30mg/m^2/d.

简介：PURPOSE：Toevaluatesingle-agentactivityofbevacizumabinpatientswithrecurrentglioblastoma.PATIENTSANDMETH-ODS：Patientswithrecurrentglioblastomaweretreatedwithbevacizumab10mg/kgevery2weeks.Aftertumorprogression,patientswereimmediatelytreatedwithbevacizumabincombinationwithirinotecan340mg/m^2or125mg/m^2every2weeks,dependingonuseofenzyme-inducingantiepilepticdrugs.Completepatientevaluationswererepeatedevery4weeks.RESULTS：Forty-eightheavilypretreatedpatientswereaccruedtothisstudy.Thromboembolicevents（12.5%）,hypertension（12.5%）,hypophosphatemia（6%）,andthrombocytopenia（6%）werethemostcommondrug-associatedadverseevents.Sixpatients（12.5%）wereremovedfromstudyfordrug-associatedtoxicity（fivethromboembolicevents,onebowelperforation）.

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简介：PURPOSE：Fotemustineisanitrosoureacompoundusedforthetreatmentofmalignantgliomas,especiallyinFrance.Recently,anEORTC-NCICstudyhasshownthataconcomitantcombinationofradiotherapyplustemozolomide（anoralcytotoxicdrug）improvedsurvivalinglioblastomapatients.Wesetouttotestaconcurrentcombinationofradiotherapyandfotemustinefornewlymalignantgliomas.

简介：BACKGROUND：SupratentorialPNET（sPNET）arerareCNStumorsofembryonaloriginarisinginchildrenandadults.Thetreat-mentofsPNETforallagegroupsatourcancercenterhasbeenbasedonthemanagementofmedulloblastoma（MB）,involvingneurosurgicaldebulkingfollowedbyeranio-spinalirradiation（CS1）andsystemicchemotherapy.METHODS：MedicalrecordswerereviewedtogatherdemographicandclinicaldataaboutallembryonalCNStumorsinchildrenandadultsfrom2001to2007.Tumorpathology,clinicalmanagementandsurvivaldatawerealsoassessed,particularlyasregardsthosepatientswhoreceivedthePackerchemotherapyregimenforeithersPNETorMB.

简介：Humanglioblastomas(GBM)arethoughttobeinitiatedbygliomastem-likecells(GSLCs).GSLCsalsoparticipateintumorneovascularizationbytransdifferentiatingintovascularendothelialcells.Here,wereportacriticalroleofGSLCsintheformationofvasculogenicmimicry(VM),whichdefineschannelslinedbytumorcellstosupplynutrientstoearlygrowingtumorsandtumor

简介：Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood

简介：RoleofEarlyPostradiationMagneticResonanceImagingScansinChildrenwithDiffuseIntrinsicPontineGlioma.

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