简介：无

简介：摘要血清糖抗原19-9(CA19-9)和癌胚抗原(CEA)检测具有便捷、快速、成本低、易普及、等优点，在基层医院中容易实现。本研究回顾性分析金华市人民医院收治的723例患者的临床资料，评估血清CA19-9和CEA对胰腺癌患者的诊断价值。结果表明，胰腺癌患者的血清CA19-9水平高于非胰腺癌患者，在出现淋巴结转移的患者中CA19-9的阳性表达率高于CEA的阳性表达率。血清CA19-9在基层医院对胰腺癌患者的筛查价值更高，CEA对病期进展的评估有辅助作用。

简介：摘要42例胰体尾癌患者根据初次就诊时的血清淋巴细胞绝对值(ALC)、CEA及CA19-9水平被分为血清ALC低下组、CEA及CA19-9升高组及其对应的正常组，分析血清ALC、CEA、CA19-9水平与临床病理参数的关系及对患者总生存期的影响。结果显示CEA升高与伴有肝转移及TNM分期晚有相关性。血清ALC低下组、CEA及CA19-9升高组患者的中位生存期均较其对应的正常组患者明显缩短。血清ALC低下组患者的CEA水平与预后密切相关，血清ALC正常组患者的CA19-9水平与预后密切相关。因此，在应用血清CEA、CA19-9对胰体尾癌患者进行病情评估及预后判断时同时考虑患者血清ALC水平可提高对胰体尾癌病情预测的准确性。

简介：摘要：目的：分析探讨在宫颈癌诊断中应用 HPV、 CA125、 CA153、 CA199联合检测的临床价值。方法：选择在本院被确诊为宫颈癌的患者 64例设定为观察组，择同期健康体检者 64例纳入对照组，对比分析两组患者血清肿瘤标志物水平。结果：观察组患者各项血清肿瘤标志物指标均明显高于对照组，组间数值对比具有显著差异， P<0.05。结论：在宫颈癌诊断中采用 HPV、 CA125、 CA153、 CA199联合检测具有显著效果，对提高诊断敏感性具有积极意义，值得推广。

简介：

简介：无

简介：

简介：摘要目的探讨分析炎症因子C反应蛋白(CRP)、淀粉样蛋白A(SAA)联合癌胚抗原(CEA)、糖类抗原242(CA242)、糖类抗原50(CA50)检测对结肠癌的诊断价值。方法收集中国科学院大学附属肿瘤医院2019年1月至6月177例首诊结肠癌患者、74例结肠息肉患者和58例健康体检者分为结肠癌组、结肠息肉组和健康对照组，分析各组CRP、SAA、CEA、CA242、CA50水平并计算其诊断结肠癌的效率，比较不同分期结肠癌的相应水平。结果结肠癌组CRP、SAA、CEA、CA242、CA50水平较结肠息肉组、健康对照组明显升高(P<0.05)；结肠息肉组CRP、SAA、CEA水平较健康对照组明显升高(P<0.05)。CRP、SAA、CEA、CA242、CA50联合诊断结肠癌的AUC为0.818，灵敏度和特异度均高于单独检测。Ⅳ期结肠癌CRP、SAA、CEA、CA242、CA50水平较0~Ⅲ期明显增高(P<0.05)。结论炎症因子CRP、SAA联合CEA、CA242、CA50可以提高结肠癌的诊断效率，并有助于结肠癌病情的判断，尤其对伴远处转移的Ⅳ期结肠癌的诊断意义较大。

简介：

简介：摘 要：目的 研究癌胚抗原（CEA）、甲胎蛋白（AFP）、糖类抗原199（CA199）、糖类抗原（CA724）联合检测在消化系统恶性肿瘤中的临床价值。方法 累计在2020年4月到2020年

简介：摘要目的回顾性分析新型冠状病毒肺炎(COVID-19)患者的临床资料，认识重症COVID-19患者的临床特征，切实指导临床实际工作。方法总结分析2020年1月28日至2020年2月12日于北京佑安医院住院治疗的确诊为COVID-19重型、危重型19名患者的临床资料，包括患者年龄、性别、病程、流行病学史、既往史、临床症状、实验室检查、肺部CT表现、治疗以及临床结局。统计学处理采用SPSS 22.0软件。结果被纳入本研究的19名患者，重型10例、危重型9例；年龄58～94岁，平均75岁；男性10人、女性9人。病程从1～14 d不等，病程中位数5 d。4人有明确的武汉居住史、13人与确诊患者有密切接触者(包括家庭聚会、共餐、同居一室等)、2人无相关的流行病学史。14人患有慢性基础病(其中高血压病11例、冠心病4例、心功能不全4例、慢阻肺3例、陈旧性前壁心梗2例、心律失常3例、心脏瓣膜病1例、糖尿病2例、慢性肾病2例等)，4例患者同时合并3种及以上基础病。首发症状主要为发热18例、咳嗽13例、呼吸困难8例。就诊时17例患者伴有淋巴细胞计数低于正常范围，11例有不同程度的肝脏功能异常，10例患者心肌酶谱异常，7名患者不同程度的肾功能损害。18名患者C-反应蛋白升高。12例接受激素治疗，4例接受丙球治疗，无创呼吸机机械通气3例，有创呼吸机协助通气7例。1例患者接受持续血液净化(continuous renal replacement therapy，CRRT)治疗，1例患者接受体外膜肺氧合(extracorporeal membrane oxygenation，ECMO)治疗；截至2020年2月17日，10例患者病情好转，4例患者仍在ICU治疗，5例患者死亡。结论老年人以及合并有慢性基础疾病患者更易发展为重型、危重型病例。淋巴细胞计数降低、C-反应蛋白水平升高、肝肾功能及心肌酶谱异常与重症化相关。激素及呼吸机治疗重症有效。

简介：【摘要】目的 关于血清CA125、HE4和CA199在子宫内膜异位症患者当中检测的价值。方法 将2019年4月到2020年10月到我院进行治疗的38例确诊为子宫内膜异位症的患者设为观察组，另选同期来我院进行体检的50名健康女性作为对照组，对所有研究对象均进行血清CA125、HE4和CA199的检验，并进行比较，分析血清CA125、HE4和CA199在子宫内膜异位症患者检验当中的意义。结果 （1）观察组的血清CA125、HE4和CA199检验水平明显高于对照组，差异有显著统计学意义（P＜0.001）；（2）观察组中，Ⅰ~Ⅱ期患者的血清CA125、HE4和CA199检验水平明显高于Ⅲ~Ⅶ期患者的水平，差异有显著统计学意义（P＜0.001）。结论 子宫内膜异位症患者和健康人的血清CA125、HE4和CA199水平存在差异，且病情越严重，相关指标水平越高，所以将以上指标应用在子宫内膜异位症患者的检测中具有实用价值，值得推荐。

简介：摘要Coronavirus disease (COVID-19), the infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported on December 31, 2019. Because it has only been studied for just over three months, our understanding of this disease is still incomplete, particularly regarding its sequelae and long-term outcomes. Moreover, very little has been written about the rehabilitation needs of patients with COVID-19 after discharge from acute care. The objective of this report is to answer the question " What rehabilitation services do survivors of COVID-19 require？" The question was asked within the context of a subacute hospital delivering geriatric inpatient and outpatient rehabilitation services. Three areas relevant to rehabilitation after COVID-19 were identified. First, details of how patients may present have been summarized, including comorbidities, complications from an intensive care unit stay with or without intubation, and the effects of the virus on multiple body systems, including those pertaining to cardiac, neurological, cognitive, and mental health. Second, I have suggested procedures regarding the design of inpatient rehabilitation units for COVID-19 survivors, staffing issues, and considerations for outpatient rehabilitation. Third, guidelines for rehabilitation (physiotherapy, occupational therapy, speech-language pathology) following COVID-19 have been proposed with respect to recovery of the respiratory system as well as recovery of mobility and function. A thorough assessment and an individualized, progressive treatment plan which focuses on function, disability, and return to participation in society will help each patient to maximize their function and quality of life. Careful consideration of the rehabilitation environment will ensure that all patients recover as completely as possible.

简介：AbstractCoronavirus disease 2019 (COVID-19) is a newly emerged infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The number of COVID-19 cases is continuously increasing and no effective drugs or vaccines are currently available. Accurate and efficient diagnostic testing methods are desperately needed for the detection of SARS-CoV-2 and antiviral antibodies in infected individuals. Various assay techniques, including nucleic acid tests [eg, polymerase chain reaction (PCR), reverse transcription-PCR, real-time loop-mediated isothermal amplification, and CRISPR-Cas-based detection], serological tests [eg, immunoglobulin (Ig)A, IgM/G], imaging tests (eg, computed tomography and positron-emission tomography), and nanoparticle-based detections have been reported for COVID-19 diagnosis. This review aims to present the current diagnostic tools for SARS-CoV-2 and their performance characteristics to inform the appropriate selection of diagnostic and surveillance technologies at optimal testing times. We also describe the advantages of detection using combined nucleic acid and imaging tests, or serological testing and point-of-care diagnostics. Developing reliable protein biomarkers targeting the conserved proteins of SARS-CoV-2 rather than IgA, IgM, or IgG would be useful to manage SARS-CoV-2.

简介：无

简介：AbstractSince the outbreak of the novel coronavirus in Wuhan, China, as obstetricians, we also face great challenges. We need to identify pregnant patients with 2019 coronavirus disease infection timely, and give them appropriate treatment in order to obtain a good maternal and infant prognosis. Here, we would like to share a case and provide some suggestions on how to screen, diagnose and treat pregnant women with 2019 coronavirus disease infection during the outbreak.

简介：无

简介：无

简介：AbstractIntroduction:The transmission pathways of coronavirus disease 2019 (COVID-19) remain not completely clear. In this case study the test for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pharyngeal swab and anal swab were compared.Case presentation:A 3-month-old girl was admitted to our hospital with COVID-19. Her parents had both been diagnosed with COVID-19. The results of pharyngeal swab and anal swab of the little girl were recorded and compared during the course of the disease. The oropharyngeal specimen showed negative result for SARS-CoV-2 on the 14th day after onset of the illness. However, the anal swab was still positive for SARS-CoV-2 on the 28th day after the onset of the illness.Conclusion:The possibility of fecal-oral transmission of COVID-19 should be assessed. Personal hygiene during home quarantine merits considerable attention.

简介：摘要BACKGROUNDCoronavirus disease 2019 (COVID-19) caused by a new Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a global pandemic. Gathered clinicopathological evidence in COVID-19 patients shows that alveoli injuries and interstitial changes are the major mechanisms of impaired O2/CO2 exchange. Few rehabilitation exercises concerning COVID-19 patients were reported. Here, we present a modified version of rehabilitation exercises based on the underlying mechanism of the disease to mild cases of COVID-19. These exercises aimed to improve the pulmonary function of patients and ease the expectoration process. Additionally, an essential branch of Traditional Chinese Medicine (TCM) named acupressure was integrated into the exercises to facilitate the recovery and maintenance of pulmonary function.METHODSFrom March 4, 2020 to May 5, 2020, a total of 60 COVID-19 patients who completed the full course of MRE were enrolled in this observational study. The diagnostic and classification criteria were based on the 7th edition of Diagnosis and Treatment Guideline of COVID-19 published by the National Health Commission of the People′s Republic of China. We prospectively gathered patients′ reported outcomes concerning respiration-related symptoms at four different time points, including: (I) at admission; (II) at the time of hospital discharge; (III) two weeks after discharge; (IV) four weeks after discharge. The reported respiratory symptoms included dry cough, productive cough, difficulty in expectoration, and dyspnea.RESULTSIn total, 60 confirmed mild COVID-19 cases were enrolled with a median age of 54 years old. The baseline prevalence for dry cough, productive cough, difficulty in expectoration, and dyspnea were 41.7%, 43.3%, 35.0%, and 50.0%, respectively. The pronounced decline in symptom prevalence was recorded over time. Interestingly, four weeks after discharge, we noticed a lower remission rate in productive cough and difficulty in expectoration.CONCLUSIONThe modified rehabilitation exercises were retrieved from the Eight-Section Brocade, and are specifically designed for rehabilitation of COVID-19 patients at home or health facilities. Based on current findings on pronouncedly improved remission rate in respiratory symptoms, we recommend the MRE as suitable rehabilitation exercise to smooth respiration and ease the expectoration process in mild COVID-19 cases.