简介：OnJune3-4,2015,ChinaInstituteofInternationalStudiesandSino-RussianFriendship,PeaceandDevelopmentCounciljointlyhostedtheinternationalconferenceon'MemorizingtheHistoryandCreatingtheFuture:InCommemorationofthe70thAnniversaryoftheVictoryofWorldAnti-fascistWar'inBeijing.DelegatesfromChinaandRussiaexplored

简介：AIM:Toinvestigatetheanti-apoptoticcapabilityofthehepatitisBvirus(HBV)intheHepG2hepatomacelllineandtheunderlyingmechanisms.METHODS:CellviabilityandapoptosisweremeasuredbyMTTassayandflowcytometry,respectively.Targetedknockdownofmanganesesuperoxidedismutase(MnSOD),AMP-activatedproteinkinase(AMPK)andhepatitisBvirusXprotein(HBx)genesaswellasAMPKagonistAICARandantagonistcompoundCwereemployedtodeterminethecorrelationsofexpressionofthesegenes.RESULTS:HBVmarkedlyprotectedthehepatomacellsfromgrowthsuppressionandcelldeathintheconditionofserumdeprivation.AdecreaseofsuperoxideanionproductionaccompaniedwithanincreaseofMnSODexpressionandactivitywasfoundinHepG2.215cells.Moreover,AMPKactivationcontributedtotheup-regulationofMnSOD.HBxproteinwasidentifiedtoinducetheexpressionofAMPKandMnSOD.CONCLUSION:OurresultssuggestthatHBVsuppressesmitochondrialsuperoxidelevelandexertsanantiapoptoticeffectbyactivatingAMPK/MnSODsignalingpathway,whichmayprovideanovelpharmacologicalstrategytopreventHCC.

简介：Anewcerebroside,1-O-(β-D-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2′R)-2’-hydroxylignoceranoylamino]-4,8-tetradecene-3-diolwasisolatedfromthe60%EtOHextractoftraditionalChinesemedicalplantCyperusrotundusL.Itsstructurewasdeterminedonthebasisofspectroscopicdata.Thisnewcompoundshowedanti-proliferationeffectonvascularsmoothmusclecells(VSMCs).

简介：Thirty-ninewomenofreproductiveagesufferingfromchronicpelvicinflammatorydisease(PID)foratleasttwoyears,previouslytreatedpharmacologicallywithnoeffect,wereenrolledinafour-weektherapeuticprotocolconsistingof12acupuncturetreatmentsperformedwiththefrequencyofthreeperweek.Ineachfemalepatientatbaselineandafterthestudy,painscoreandthefollowingparametersinbloodserumwereevaluated:concentrationofimmunoglobulinM(IgM),albumins,alphal-globulins,alpha2-globulinsandgamma-globulins,erythrocytesedimentationrate(ESR)andwhitebloodcell(WBC)count.Duringthestudy,weobtainedasignificantdropinESRandIgMlevelstogetherwithariseingamma-globulinconcentrations.Asignificantdecrease(from4.89±0.82to0.63±1.05)inpainscorewas

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简介：Vagusnervestimulationexertsprotectiveeffectsagainstischemicbraininjury;however,theunderlyingmechanismsremainunclear.Inthisstudy,aratmodeloffocalcerebralischemiawasestablishedusingtheocclusionmethod,andtherightvagusnervewasgivenelectricalstimulation(constantcurrentof0.5mA;pulsewidth,0.5ms;frequency,20Hz;duration,30seconds;every5minutesforatotalof60minutes)30minutes,12hours,and1,2,3,7and14daysaftersurgery.Electricalstimulationofthevagusnervesubstantiallyreducedinfarctvolume,improvedneurologicalfunction,anddecreasedtheexpressionlevelsoftumornecrosisfactor-αandinterleukin-6inratswithfocalcerebralischemia.Theexperimentalfindingsindicatethattheneuroprotectiveeffectofvagusnervestimulationfollowingcerebralischemiamaybeassociatedwiththeinhibitionoftumornecrosisfactor-αandinterleukin-6expression.

简介：UsingTime-VaryingAR(TVAR)modelandadaptivenotchfilterisanewmethodforthenon-stationaryjammersuppressioninDirectSequenceSpreadSpectrum(DSSS).TheperformanceofTVARmodelforInstantaneousFrequency(IF)estimationwillbeaffectedbysomefactorssuchasbasisfunctions.Focusingonthisproblem,theoptimalbasisfunctionofTVARmodelfortheIFestimationoftheLFMsignalisobtainedinthispaper.Besidesthedepthandwidthofnotching,thephasepropertiesofnotchfilteraffecttheSignal-to-Interferenceplus-NoiseRatio(SINR)ofcorrelationoutputtothenarrowbandjammersuppressioninDSSS,inresponsetotheproblemtheclosedsolutionofcorrelationoutputSINRimprovementhasbeenderivedwhenasinglefrequencyjammerpassesthroughdirectIIRnotchfilter,anditsperformancehasbeencomparedwiththoseoffivecoefficientFIRfilters.Later,anovelmethodforLFMjammersuppressionbasedonFourierbasisTVARmodelanddirectIIRnotchfilterisproposed.Thesimulationresultsshowtheeffectivenessoftheproposedmethod.

简介：Objective:Therecurrenceorprogressionunderendocrinetherapyinhormonereceptor-positive(HR+)advancedbreastcancer(ABC)remainedacriticalclinicalchallenge.Chidamideisanoralsubtype-selectivehistonedeacetylase(HDAC)inhibitorwithmultiplefunctionsintumorgrowthinhibitionandmicroenvironmentmodulationviaepigeneticreprogramming.Thepurposeofthisstudywastoevaluatethesafety,pharmacokinetics(PK),andpreliminaryefficacyofchidamideincombinationwithexemestaneinHR+ABCpatients.Methods:EligiblepatientswerepostmenopausalwomenwithHR+ABCrecurrentorprogressedtoatleastoneendocrinetherapy.Bloodsampleswereobtainedintherun-inperiodandthefirstdayofcombinationtreatmentforPKanalysis.Incombinationtreatment,patientsweregivenexemestane25mgdailyandchidamide30mgtwiceaweek(BIW)untilprogressionofdiseaseorintolerabletoxicities.Atreatmentcyclewasdefinedas4weeks.Safety,PKparameters,andpreliminaryefficacywereevaluated.Results:Atotalof20patientswereenrolledbetweenJulyandDecember,2015.Themediannumberoftreatmentscyclewas5.2(20.8weeks)with2patientsstillontreatmentatthedatacut-offdateofOctober,2017.Thetreatment-relatedadverseevents(AE)≥grade3inmorethan2patientswereneutropenia(35%),thrombocytopenia(30%),andleucopenia(20%).Theplasmaexposureofexemestanewasconsistentinthepresenceorabsenceofchidamide.Aslightincreaseinchidamideexposurewasnotedinthepresenceofexemestane,probablyduetotheinter-andintra-patientvariations.Thebestresponsein16evaluablepatientswasassessedbyResponseEvaluationCriteriainSolidTumors(RECIST),including4patientswithpartialresponse,10patientswithstabledisease.Themedianprogression-freesurvival(PFS)was7.6months.Conclusions:ThecombinationofchidamidewithexemestanewasgenerallywelltoleratedwithpromisingpreliminaryefficacyinHR+ABCpatients.Theoverallresultsfromthisstudyencouragefurtherpivotaltrialinthispatie

简介：AbstractObjective:To evaluate the efficacy of progestin-primed ovarian stimulation (PPOS) protocol in infertile women with high basal follicle-stimulating hormone (FSH) levels ≥15 IU/L.Methods:Patients with high basal FSH levels ≥15 IU/L with autologous oocytes from September 2016 to March 2019 were reviewed. Either medroxyprogesterone acetate 4 mg/d or clomiphene citrate (CC) 50 mg/d was administered daily from day 3 to the trigger day. When serum FSH levels decreased to ≤15.0 IU/L, a low dose of human menopausal gonadotropin (hMG) 75/150 IU/d was administered to promote late follicular development.Results:Two hundred and twenty women were retrospectively analyzed in this study. Among them, 139 patients were administered with PPOS protocol as the study group, and 81 patients were administered with CC protocol as the control group. The numbers of received oocytes and viable embryos were higher in the study group than those in the control group (1.5 ± 1.2 vs. 1.2 ± 0.8 and 0.8 ± 0.8 vs. 0.5 ± 0.6, respectively, P < 0.05). However, hMG duration and dosage were significantly higher in the study group than those in the control group (4.2 ± 2.7 d vs. 1.1 ± 2.3 d and 609.1 ± 424.5 IU vs. 140.7 ± 231.3 IU, respectively, P < 0.01). Incidence of luteinizing hormone surge and cycle cancellation rate were lower in the study group than those in the control group with statistical difference (2.88% vs. 16.05% and 36.50% vs. 50.63%, respectively, P < 0.05).Conclusions:PPOS protocol can effectively downregulate the endogenous FSH levels. Compared with CC protocol, treatment with PPOS protocol in patients with high basal FSH levels ≥15 IU/L could receive more oocytes and more viable embryos.

简介：同步讲解SectionA1.usingthecomputer使用电脑usev.使用;运用使用;运用Asastudent,youshouldlearnhowtouseadictionary.作为学生,你应该学会如何使用词典。拓展(1)use与for或as连用,构成短语use...for,意为'用来做……;为了……而使用',use...as意为'作为……使用;用作……'。Bamboocanbeusedforcarryingwater.

简介：I’mafraid…通常甩作对集事已经发生或很可能发生表示遗憾或抱歉的客套语，意为“(我)恐怕…”。I’mafraid…的使用可以使说话人的语气变得比较婉转、客气、有礼貌，在它的前面或后面通常有一个从句，具体地说明事由。I'mafraid常用于以下几种场合：

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简介：院外静脉溶栓治疗AMI方法 ,静脉溶栓治疗AMI简单,一院外诊断AMI需要快速、准确

简介：MгиMO是莫斯科国立国际关系学院(MOCKOBCKийгocyдapcTBeHHbIйиHCTиTyTMeждyHapoдHbIxOTHOшeHий)的简称，是俄罗斯外交部直属的高等学校。它创建于1944年，是在莫斯科大学国际关系系的基础上建立起来的。经过60年的发展，以前只有国际、经济、法律三个系的“国关”，

简介：摘要：本文就秦二厂3/4#机组与1/2#机组在压空系统设备组成和事故处理两方面的差异进行了分析总结，并从工艺系统设备失去压缩空气以后的状态变化，对安全壳内和安全壳外仪表用压缩空气失效的事故规程进行分析和总结，而且就事故规程的可用性和正常压空生产系统失效的事件反馈进行了分析，最后结合实际机组的运行对其分别提出了一些建议，以利于在今后的工作中对3/4#机组这边的压空运行状态更加的了解，在事故预想方面准备的更加充分，并更深一步的提高运行人员在压空发生故障时紧急干预和机组状态控制的能力。

简介：在大城市，很多上班族或学生一般都是先乘坐公交车（BUS），到达最近的地铁（Metro），出了地铁以后再走一段（Walk），才到达目的地。这样的出行方式就叫做B—M—W，以此方式出行的人就叫做。B—M—W族”。

简介：宿舍的床尺寸大概是900mm×2000mm,2㎡左右的面积,加上床下对应的空间,这是你一个人的专属范围。尽情地实践自己所有的疯狂点子,没有什么是不可能的!蒙德里安的格子这个床位的改造采用了蒙德里安的抽象画,在红蓝黄的矩形格子中融入了收纳、桌板等多种功能。

简介：Itisoftenstatedthatevencleantokamakdischargesdisruptathighdensity.Onepossibilityisthatsuchdisruptionresultfromtheenergylossarisingfromhydrogenrecyclingattheedgeoftheplasma.thisenergylosscouldleadtoacontractionofthecurrentchannelandtheproductionofadisruptivelyunstableconfiguration.

简介：华硕系列笔记本中有12.1寸的轻薄型机器S5N、M5N，有15寸宽屏幕的M6N，在迷你领域有10寸屏幕的S200N，那么既兼顾移动性，又兼顾性能的14寸屏幕领域呢？对了，就是这款M3N了。

简介：iPod的魅力让其他任何厂商的任何数码播放器系列都望尘莫及，而iProne的推出在改变人们对手机传统认识的时候，也再一次捍卫和巩固了苹果产品尊贵的地位。竞争对手得到的压力空前巨大，但配件厂商却积极地加入到和苹果产品一起发展的行列当中，过去的“MadeforiPod”战略也逐渐扩展到了“MadeforiPhone”，实现苹果和配件厂商双赢的效果。