简介:目的探讨巨大听神经瘤的显微外科切除技术和有关的局部解剖,以及术后处理措施.方法本组对32例病人进行了分析总结.采取乙状窦后入路暴露肿瘤,穿刺侧脑室后角充分引流脑室液,减低颅内压.在显微镜下保留外层蛛网膜,自上极囊内逐步切除肿瘤,最后分离内听道部分,术中记载重要结构的分布.结果肿瘤全切除27例(85%),次全切除5例(15%),无死亡.面神经保留27例(85%).受压面神经术中观察:位于肿瘤前上壁30例,上极2例,无后壁者.肿瘤由小脑前上动脉供血(AICA)17例,双重供血7例.结论采取显微外科技术,掌握听神经瘤的局部解剖关系,加强手术后的观察处理是提高听神经瘤疗效,减少损伤的关键.
简介:目的评价卡铂为基础的宫颈癌新辅助化疗的疗效及其毒副作用。方法收集2003年1月~2005年4月在我院以卡铂+5氟脲嘧啶(5-Fu)方案进行单疗程新辅助化疗的宫颈癌患者共32例,观察化疗前后宫颈局部肿瘤病灶大小的变化、症状缓解情况以及化疗的毒副作用。结果32例患者中,临床CR与PR分别是9.4%(3/32)和56.3%(18/32),总有效率是65.6%(21/32),组织学CR1例,占3.1%。症状缓解方面。显效率为56.3%(18/32),有效率为25.0%(8/32)。非参数检验显示不同临床分期、病理类型、组织学分级及肿块大小(最大径〉4cm与≤4cm)的化疗疗效差异无显著性,Spearman检验也未发现化疗疗效与上述因素的显著相关性。骨髓抑制是本化疗方案最为显著的毒副作用,主要为Ⅰ~Ⅱ度,分别为31.3%(10/32)、34.4%(11/32),Ⅲ度和Ⅳ度骨髓抑制分别为6.3%(2/32)、3.1%(1/32)。32例患者中,无肝肾功能损害病例。结论卡铂联合5FU作为宫颈癌NACT方案是有效、可行、安全的。但影响疗效的因素、远期疗效及对生存率的影响还有待于进一步扩大病例数以及长期的随访追踪。
简介:Thetitlecomplexi-C4H9Co(salen)(Py)(Py=pyridine.salen=dianionofdisalicylideneethylenediamine)hasbeenfirstsynthesized.ItscrystalstructurehasbeendeterminedbyX-raydiffractionmethod.ThecrystsisaremonoclinicwithspacegroupP21/C.Theunitcellparametesarepresented.ThestructurehasbeenrefinedtoafinalRof0.038.
简介:Toinvestigatetheexistenceofthemajoroutermembranepmtein(MOMP)geneLip132in15dominantChinesestrainsof15semgroupsofLeptospirairaerrogansand2intemationalstrainsof2semgroupsofLeptospirabiflexa,andtocloneandconstructtheexpressionsystemaswellastoidentifytherecombinantpmteins,genomicDNAsfromstrainsofleptospirawerepreparedbymutinephenol-chloroformmethod,andthefragmentsoftheLipL32genewiththewholelengthfromthestrainswereamplifiedwithhighfidelityPCR.Thetargetamplificationproductswere,sequencedafterT-Acloning,andtheexpressionsystemforthegenesweretherebyconstructed,ExpressionoftherecombinantproteinswasidentifiedbyusingSDSPAGEafterinductionwithIPTGatdifferentdosages.WesternblotassayswithrabbitantiserumagainstthewholecellofTR/PatocⅠofLeptospiraandimmunizedserumwithrMOMPswereusedtodeterminetheimmunoreactivityandimmunogenicityoftherecombinantproteins.Microscopicagglutinationtestwasusedtodeterminethecross-agglutinationtitresinrabbitseraimmunizedwithrMOMPs,andthecelladherencemodelofLeptospirawasusedtoexaminetheblockingeffectsofrabbitantiseraagainsttheserMOMPs.ItwasfoundthattheLipL32genecouldbefoundinallthe17strainsofLeptospiramentionedabovewithtwodifferentgenotypes,i.e.LipL32/1andLipL32/2.AmountsofexpressionsofrMOMP1andrMOMP2afterIPTGaccountedfor40%and10%ofthetotalbacterialpmteinsrespectively.BothrMOMP1andrMOMP2couldcombinewiththerab-bitantiserumagainstleptospiralTR/PatocⅠ,andcouldinducetheproductionofagglutinationantibodiestothese17strainsofLeptospirawith1:2to1:64MATtitres.Therabbitanti-rMOMP1andanti-MOMP2antibodiesat1:2to1:16dilutionscouldefficientlyblockadherenceofLeptospira.ItconcludesthatalltheLeptospiratestedinthepresentstudypossessLipL32/1orLipL32/2genes,andtheconstructedexpressionsystemcanexpresstherMOMP1andrMOMP2.
简介:瑞萨科技公司近日推出适用于工业产品和办公自动化产品的H8SX/1582F型单片微控制器。与H8SCPU芯核相比,H8SX32位CPU芯核增加了寻址方式和新的指令,而且ROM存储器代码的效率提高了将近20%。H8SX/1582F采用5V单
简介:<正>Foranyintegersa1,a2,a3,a4andcwitha1a2a3a40(modp),thispapershowsthatthereexistsasolutionX=(x1,x2,x3,x4)∈Z4ofthecongruencea1x12+a2x22+a3x32+a4x42≡c(modp)suchthat‖X‖=max{|x1|,|x2|,|x3|,|x4|}《p1/2logp.
简介:Twonewlybredhybridricecombinations,superhigh-yieldingLiangyoupeijiu(Pei'ai64S×9311)andPei'ai64S/E32(Pei'ai64S×E32)wereusedtoinvestigatethephotosyntheticcharacteristicsunderhightemperatureincomparisonwithhybridriceShangyou63.Hightemperaturecausedadecreasedphotosyntheticefficiencyandaggravatedphotoinhibition.TheoptimumtemperatureforphotosyntheticelectrontransportationandphotosyntheticCO2fixationwereabout28℃and35-40℃respectively.Linearelectrontransportationismoresensitivetohightemperaturethanthephotochemicalprocess.Themechanismofhightemperatureadaptationwaspossiblyasfollows:superhigh-yieldingricehasquicklyincreasingcarotenoid,whichactedasamorefavorableantioxidantsystemtoreducetheactiveoxygenproductionandavoiddamagetothephotosynthesissystem;superhigh-yieldingricehasahigherefficiencyofxanthophyllscycletodissipateexcessheatenergy;superhigh-yieldingricehasamorestablephotosyntheticfunction,higherphotosyntheticefficiencyandmoreheatstableproteincontent.
简介:QHD32-6油田主要含油层系是被断层复杂化了的明化镇组下段和馆陶组上段河流相砂体,砂体厚度横向变化较大.油藏形成受构造和岩性双重因素控制,存在多个油水系统,地质条件比较复杂.油田含油面积为39.7km2,探明储量为1.7034亿t.开发好该油田的一个重要环节是针对其特有的地质条件做好随钻油藏地质建模工作,即随着开发井钻探方案的实施分阶段进行油藏地质模型调整,以指导开发井井网的调整和开发井的钻探.以地质框架模型建立、绝对波阻抗反演、岩性序贯高斯指示模拟、孔隙度高斯协模拟等技术为核心建立的随机模拟法,被证明是适合该油田地质特点的随钻油藏地质建模方法,应用于该油田A、B平台所在区块取得了良好的效果.