简介：

简介：

简介：

简介：Objective:Differentiatedthyroidcarcinomas(DTCs)areclassifiedintopapillarythyroidcarcinoma(PTC)andfollicularthyroidcarcinoma(FTC).DTCsareanalyzedasasinglegroupinclinicalstudiesthatinvestigatedtheprognosticfactorsandprognosisofthesemalignancies.However,thebiologicalbehaviorsofthesecarcinomassignificantlydiffer.Inthepresentstudy,weaimedtodetectdifferencesintheoutcomesbetweenPTCandFTCinMansouraUniversityHospitalinEgypt.Methods:Atotalof558patientswithhistologicallyproventhyroidcarcinomasfromJanuary2003toDecember2012wereretrospectivelyenrolled.Theclinicalandpathologicaldataofpatientswerereviewed.Results:Largeprimarytumorsize,lymphnodeinvolvement,extrathyroidextension,anddistantmetastasisweresignificantpoorprognosticfactorsforoverallsurvival(OS)inoldPTCpatients.Coxhazardanalysisshowedthatthepatient'sage,extrathyroidextension,anddistantmetastasisweretheonlyindependentprognosticfactors.InFTCpatients,onlythedistantmetastasisanddegreeoftumorinvasionweresignificantpoorprognosticfactorsinOSunivariateanalysis.However,thesefactorswerenonsignificantinmultivariateanalysis.The10-yearOSrateswere97%and89%forPTCandFTC,respectively(P=0.003).The10-yeardisease-freesurvival(DFS)rateswere77.2%inPTCvs.65%inFTC(P=0.179).Conclusion:ThesignificantprognosticfactorsvarybetweenthetwotypesofDTCs.Therefore,PTCandFTCpatientsneedtobeanalyzedandreportedindependently.PTCsurvivaliswidelyandsignificantlyaffectedbyage,extrathyroidextension,anddistantmetastasis.Bycontrast,thesefactorswerenonsignificantinFTC,whichshowedpoorersurvivalthanPTC.

简介：

简介：

简介：Background:Currently,thereisasignificantlackofdataconcerninglong-termoutcomesfollowingpaediatriccochlearimplantationintermsofqualityoflife.Thereisaneedforalong-term,prospectivestudyinthisregard.Thisstudyaimsathighlightingthepreliminaryresults,oneyearpostsurgeryofafiveyearprospectivestudy.Methods:TheCochlearTMPaediatricImplantedRecipientObservationalStudy（P-IROS）isaprospective,patientoutcomesregistryforroutinelyimplantedchildren.Thestudycollectsdatausingquestionnairespost-surgeryandatregularintervalsuptofiveyears.Results:AtourCentre,159cochlearimplantsurgeryprocedureswerecarriedoutbetweenJanuary2014andDecember2014.CategoryofAuditoryPerformanceIIscoreincreasedfrom‘0’to‘3’atsixmonthsandto‘5’at12monthsforchildrenaged0—3years,althoughthiswasnotstatisticallysignificant.However,thesametrendwasstatisticallysignificantfortheage3—6yearandage6—10yearbrackets.Thequalityoflifeofthechildimprovedsignificantly.Analysisofcommunicationmoderevealedastatisticallysignificantoverallshifttotheauditory-oralmodefromtotalcommunication.Conclusion:Cochlearimplantationisalife-changingintervention.Theevidenceinsupportofwhatitcanachievesafelyisclear.However,thecostsassociatedwithitraisethequestionifitwillremainaneffectiveoptionforlifeinallchildren.TheCochlearP-IROSisanattempttoanswerthesameoverafiveyearperiod.OurstudyinNewDelhi,sofarconcludesthatcochlearimplantationinapopulationwithlimitedaccesstofundsisveryeffective,oneyearaftersurgery.