简介：Background:Depressiondisordercoexistsinchronicdiseaseswithsomaticdiseasesandhashighmorbidity,disabilityandmortality.Currentresearcheshaveconfirmedthatdepressionmaybecausedbycoronaryheartdisease,hypertensionandheartfailure.Meanwhile,cardiovasculardiseasesmaycauseorworsendepression,leadingtoprolongedhospitalizationandcomplications.

简介：你的睡眠质量如何？是否有夜黑被噩梦惊醒的时候？科学研究证发现，我们正睡眠时，眼球仍然在迅速移动，那么这就表明你正在做梦，REM睡眠到底是怎么一回事？它与我们的大脑神经有何联系？相信读完下面的短文后，你就会找到答案的。

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简介：Studiesonbrain-evokedpotentialandcontingentnegativevariation(CNV)inmooddisorderremaincontroversial.Todate,noCNVdifferencebetweenunipolarandbipolardepressionhasbeenreported.Brain-evokedpotentialsweremeasuredinthepresentstudytoanalyzeCNVinthreesubtypesofmooddisorder(mania,unipolardepression,andbipolardepression),andtheseresultswerecomparedwithnormalcontrols.Inthemaniagroup,CNVamplitudeBwasgreaterthanincontrols,andthedepressiongroupexhibitedlowerCNVamplitudeBandsmallerA-S'2area,andprolongedpost-imperativenegativevariationlatency.TheCNVcomparisonbetweenunipolarandbipolardepressionfoundthattheprolongedpost-imperativenegativevariationlatencywasonlyinunipolardepression.Theseresultssuggestthatprolongedpost-imperativenegativevariationlatencyisacharacteristicofunipolardepression,andCNVamplitudechangeisastatecharacteristicofmooddisorderpatients.

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简介：ObjectiveToreportoutcomesofcochlearimplantation(CI)inachildwithauditoryneuropathyspectrumdisorder(ANSD)andtoprovidepreliminaryclinicalevidenceoftheefficacyofCIinANSDpatients.MethodsA4-year-oldboywithdiagnosedauditoryneuropathyspectrumdisorder(ANSD)receivedimplantationofaNucleusCI24Rafteranunsatisfactorytrialofamplification.Post-implantationperformanceinbothhearingsensitivityandspeechrecognitionwasassessedindifferentsessions.Aidedhearingthresholdsweretestedbybehavioralaudiometry.MandarinEarlySpeechPerceptionTest(MESP),MeaningfulAuditoryIntegrationScale(MAIS),categoryofauditoryperformance(CAP)andSpeechIntelligibilityRating(SIR)wereusedtoassessthebenefitsinauditoryskillsorspeechrecognitiontheboyobtainedfromCI.Thetestswereadministeredbeforesurgeryandat3monthsand7monthsafteropening.ResultsTheboydemonstratedimprovedauditorysensitivitybyusingCI.Concerningspeechrecognitionandcommunication,bothspeechaudiometryandquestionnairesshowedanobviousbenefitfromCI.ConclusionsCIhasworkedefficientlyinthisANSDboy.ButbecauseoflimitedunderstandingofANSDandrehabilitationeffectbycochlearimplantationinthiscondition,theclinicaldecisiontoimplantshouldbecautiousandonlyafterathoroughevaluation.Meanwhile,wellcontrolledandlongtermstudiesareneededtoconfirmtheefficacyofcochlearimplantationinpatientswithANSD.

简介：针刺内关．足三里．乳根和肩贞穴．温灸膻中．治疗了62例产后缺乳患者。经7次治疗．30例产妇乳汁分泌每天400mL以上．精神饱满；26例乳汁分泌每天250mL左右．需补充牛奶喂养婴儿；6例乳汁分泌无明显改善．挤压双侧乳房极少量乳汁分泌。

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简介：由独立介绍混乱的四种基本类型进一个二维的三角形的格子，我们在结果的颤动决定混乱的每种类型的角色集体春天的网络。我们主要担心在波色子山峰和横向的Ioffe-Regel限制之间的波色子山峰和连接的起源。为混乱的所有类型，我们观察波色子山峰和Ioffe-Regel限制的出现。与增加混乱，波色子山峰频率BP,横向的Ioffe-Regel频率红外T,和纵的Ioffe-Regel频率红外L都减少。我们发现有二个方法让波色子山峰形成：发展从并且共存与(但是留下的独立人士)横向的货车胀起奇特没有并且与本地协作数字变化。仅仅当混乱是足够地强壮的并且引起本地协作的空间变化时，面对混乱，红外TBP,和红外TBP的一种单个类型数。而且如果没有位置的混乱，红外T红外L。因此，波色子山峰等价于横向的Ioffe-Regel限制的争论不是一般的。我们的结果两个都建议那本地协作数字和位置的混乱是必要的让争论成立，它实际上是为象在边际地堵塞的固体和结构的眼镜那样的很混乱的固体的盒子。我们进一步联合混乱的二种类型在本地协作数字和格子地点位置引起混乱。产生网络的震动的状态的密度类似于在边际地堵塞的固体的很好。然而，在波色子山峰之间的关系和横向的Ioffe-Regel限制仍然是不定的并且条件依赖者。因此，在混乱的不同类型之间的相互影响是复杂的，并且更多的深入的研究被要求整理它。

简介：Cerebralpalsyisoneoftheimportantfactorsinchildren'sdisability.Patients'seatdysfunctionhasaseriousimpactontheirdailylifeandtheirfamily.However,thereiscurrentlynoeffectivetreatmentforthecerebralpalsyseatdysfunction.So,itisofimportancetosearchanewwaytomakeabreakthrough.Acupuncturehassignificantadvantagesinthetreatmentoffunctionaldisorders.Inthispaper,theliteratureaboutclinicalresearchofacupuncturetreatmentofcerebralpalsyseatdysfunctionaresummarized.Wehavecarriedonthemechanismanalysisofsportsmedicinerespectivelyfromthreeangles,includingtraditionalChinesemedicine,westernmedicineandtraditionalChineseandwesternmedicinecombinedwithsportsmedicine.WeconcludethatacupuncturingacupointsonDumeridian,BeishupointsandJiajipointshassignificanteffectonthefunctionofsittingunablechildrenwithcerebralpalsy,suchasstrengtheningthespleen,tonifyingthekidneyandpromotingYangqiandstimulatingthesensorynerveandsoon.Acupuncturingpointsforthetreatmentofcerebralpalsyprovidesalotofinspirationforhumanphysiologyresearchinthefutureandclinicaltreatmentofneurologicaldiseases.

简介：目的：观察疏肝理气、清心除烦中药结合针刺治疗广泛性焦虑症的疗效。方法：治疗组用针刺结合中药治疗40例，对照组采用口服多虑平治疗38例，治疗前、中、后均作焦虑自评量表（SAS）、副反应量表（TESS）评定。结果：治疗组与对照组总有效率分别为82．5％和84．2％，两组治疗前后SAS组内比较差异有统计学意义（P〈0．01），两组间痊愈显效率、总有效率及SAS评分比较无差异（P〉0．05），但副反应对照组显著高于治疗组（P〈0．01）。结论：针刺结合中药治疗广泛性焦虑症疗效确切，且毒副反应轻微。

简介：BackgroundVocalcordmovementdisorder(VCMD)isalaryngealdisordercharacterizedbyparadoxicaladductionofthevocalcordsduringininspiration,expirationorboth.ThenursingexperienceofpatientswithVCMDafteraorticdissectionsurgeryislimited.MethodsWeretrospectivelyanalyzedtheclinicaldataandnursingrecordsof269patientsafteraorticdissectionsurgeryinGuangdongGeneralHospitalbetweenMay2010andMay2012.Weobservedthepatients’pronunciation,andjudgediftherewasdysphagiaundergoingwaterdrinkingtesttwohoursafterextubation,toconfirmwhetherpatientshadVCMD.ResultsSeventeenpatientshadVCMDafteraorticdissectionsurgery,ofwhom2sufferedhoarseness,3haddysphasiaand12hadbothhoarsenessanddysphasia.Aftertimelytreatmentandcarefullynursing,allthepatientsrecoveredwell.ConclusionsWiththeenhancedcareofpatientswithaorticdissection,observinghoarsenessappearanceanddrinkingexperimentimmediatelyafterextubationcandetectVCMDassoonaspossible.Furtherrehabilitationtrainingandpsychologycarecanpreventbuckingandaspirationeffectively,andpromotingrecoveryandimprovingpatient’slifequality.

简介：AbstractObjective:Pseudoxanthoma elasticum (PXE) is a rare genetic disorder caused by loss-of-function mutations in the ABCC6 gene. While PXE is characterized by ectopic mineralization of connective tissues clinically affecting the skin, eyes, and cardiovascular system, kidney stones were reported in some individuals with PXE. The aim of this study is to determine whether kidney stones are an incidental finding or a frequent manifestation of PXE.Methods:We first investigated the genetic basis of two siblings diagnosed with PXE. The younger patient presented with recurrent kidney stones since 8 years old. Secondly, to address whether kidney stones are associated with PXE, the prevalence of kidney stones in a survey cohort of 563 respondents with PXE was compared to that of a general U.S. population survey, National Health and Nutrition Examination Survey, with 28,629 participants.Results:Genetic analysis in both patients identified compound heterozygous mutations in ABCC6, c.2787+1G>T, and c.3774_3775insC. The analysis of participants 20 years old and older revealed that 23.4% of PXE patients had previously had a kidney stone, a significant increase compared to 9.2% in the general population (P < 0.01). In addition, 17.8% of PXE patients reported their first kidney stone episode before age of 18 years old.Conclusions:PXE correlates with an increased risk of developing kidney stones with considerable morbidity and health-care cost.

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简介：AbstractPurpose:Given the increased risk of accidents in patients with attention deficit and hyperactivity disorder (ADHD) or maternal anxiety/depression, we aimed to investigate the frequency of the two diseases in children with penetrating eye injury (PEI).Methods:Altogether 79 children, 39 with PEIs and 40 healthy individuals (control group), aged 5-15 years, underwent a complete ophthalmologic examination. Afterwards, schedule for affective disorders and schizophrenia for school-aged children was conducted to assess the psychiatric diagnosis of all children. Turgay diagnostic and statistical manual of mental disorders (DSM-IV)-based child and adolescent behavior disorders screening and rating scale (T-DSM-IV-S) was filled by parents to evaluate the severity of ADHD symptoms. The depression and anxiety levels of mothers of each group were evaluated by two self-report measures: the Beck depression scale and the state-trait anxiety inventory (STAI), respectively. Data were analyzed by IBM SPSS version 22.0. The Chi-square and Fisher's exact test were used to determine whether there is a significant difference between qualitative variables while independent sample t and Mann-Whitney U tests to compare quantitative variables.Results:The only diagnostic difference was a significantly higher frequency of ADHD among patients with PEIs (48.7% in PEI vs. 17.5% in control group, χ2 = 7.359, p = 0.007). The total scores of the T-DSM-IVS (attention subscale U = 418.000, p = 0.006; hyperactivity subscale U = 472.000, p = 0.022) and maternal state-trait anxiety inventory (maternal STAI-state U = 243.000, p = 0.003; maternal STAI-trait U = 298.000, p = 0.021) were significantly higher in the PEI group than in control group. In logistic regression, children with PEI had a tendency to have a 3.5-fold increased risk for ADHD (OR = 3.538, CI = 0.960-13.039, p = 0.058).Conclusion:ADHD was detected almost 1 in 2 children with PEIs. Besides, the maternal anxiety level was significantly higher in the PEI group than in the control group. This association should be further explored via a future prospective longitudinal study. Since a proper treatment of ADHD in children and anxiety treatment in mothers may prevent vision loss following PEIs in children.

简介：AbstractBackground:Transcranial alternating current stimulation (tACS) offers a new approach for adult patients with major depressive disorder (MDD). The study is to evaluate the efficacy and safety of tACS treating MDD.Methods:This is an 8-week, double-blind, randomized, placebo-controlled study. Ninety-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min, 77.5-Hz, 15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks (week 4), following a 4-week observation period (week 8). The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale (HDRS-17) score ≤7 at week 8. Secondary outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17, the proportion of participants having improvement in the clinical global impression-improvement, the change in HDRS-17 score (range, 0–52, with higher scores indicating more depression) over the study, and variations of brain imaging and neurocognition from baseline to week 4. Safety will be assessed by vital signs at weeks 4 and 8, and adverse events will be collected during the entire study.Discussion:The tACS applied in this trial may have treatment effects on MDD with minimal side effects.Trial registration:Chinese Clinical Trial Registry, ChiCTR1800016479; http://www.chictr.org.cn/showproj.aspx?proj=22048.