简介:AbstractHepatitis D virus (HDV) infection causes the most severe form of viral hepatitis with rapid progression to cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Although discovered > 40 years ago, little attention has been paid to this pathogen from both scientific and public communities. However, effectively combating hepatitis D requires advanced scientific knowledge and joint efforts from multi-stakeholders. In this review, we emphasized the recent advances in HDV virology, epidemiology, clinical feature, treatment, and prevention. We not only highlighted the remaining challenges but also the opportunities that can move the field forward.
简介:摘 要 铁路客车检修过程中,转向架构架常出现由于腐蚀而导致局部母材低于原设计厚度的35%,甚至达到锈穿的情况,由于局部腐蚀严重,直接对构架进行报废,会造成很大的浪费,为了保证在不影响使用性能及强度的情况下,对部分腐蚀构架进行截换修复处理。
简介:AbstractBackground:The complete mesogastrium excision (CME) based on D2 radical gastrectomy is believed to significantly reduce the local-regional recurrence compared with D2 radical gastrectomy in advanced gastric cancer, and it is widely used in China. This study aimed to explore whether D2 + CME is superior to D2 on surgical outcomes during gastrectomy from Chinese data.Methods:Feasible studies comparing the D2 + CME (D2 + CME group) and D2 (D2 group) published up to March 2020 are searched from electronic databases. The data showing surgical and complication outcomes are extracted to be pooled and analyzed.Results:Fourteen records including 1352 patients were included. The D2 + CME group had a shorter mean operative time (weighted mean difference [WMD] = -16.72 min, 95% confidence interval [CI]: -26.56 to - 6.87 min, P < 0.001), lower mean blood loss (WMD = -39.08 mL, 95% CI: -49.94 to -28.21 mL, P < 0.001), higher mean number of retrieved lymph nodes (WMD = 2.13, 95% CI: 0.58-3.67, P = 0.007), shorter time to first flatus (WMD =-0.31 d, 95% CI: -0.53 to - 0.10 d, P = 0.005), and postoperative hospital days (WMD =-1.09, 95% CI: -1.92 to -0.25, P = 0.010) than the D2 group. Subgroup analysis suggested that the advantages from the D2 + CME group were obvious in traditional open radical gastrectomy, proximal gastrectomy, and distal gastrectomy compared with D2 group. The evaluations of post-operative complications showed that the patients who underwent D2 + CME had a lower incidence of post-operative complications than the patients who underwent D2 surgery alone (relative risk [RR] = 0.65, 95% CI: 0.45-0.87, P = 0.003). The D2 radical gastrectomy plus CME improved 3-year overall survival (OS) (RR = 1.16, 95% CI: 1.02-1.32, P = 0.020) and lowered the local recurrence rate (RR = 0.51, 95% CI: 0.28-0.94, P = 0.030). The patients undergoing laparoscopic surgery or total gastrectomy had more significant advantages compared between D2 + CME and D2 groups in 3-year OS.Conclusion:The data from China show that D2 radical gastrectomy plus CME are reliable procedures and safety compared to D2 radical gastrectomy with faster recovery, lower risk, and better prognosis.
简介:【摘要】目的 分析在对深静脉血栓形成患者进行早期诊断的过程中,D二聚体(D-D)与凝血因子联合检测的效果。方法 本次研究于本院随机抽取了31例2020年3月-2021年3月接诊的早期深静脉血栓形成患者设为研究组,另选同时期接收的健康体检患者31例设为参照组。两组患者均接受D二聚体与凝血因子联合检测,对比患者的检测结果。结果 研究组接受检测后患者D二聚体指标更高,凝血因子指标更低,对比差异明显(P<0.05)。 结论 在进行早期深静脉血栓形成患者的诊断过程中,D二聚体联合凝血因子的检测能够充分显示患者在其的血浆指标变化,对深静脉血栓的形成进行提示,以便尽早采取有效的措施进行干预,适合于临床中应用。
简介:摘要目的探讨食管鳞癌患者凝血四项、D-二聚体(D-D)水平与临床病理特征的相关性。方法抽取2020年6月至2021年6月周口市第一人民医院收治的80例食管癌患者作为研究对象,所有患者均接受食管癌根治术治疗,术后行组织病理检查,记录患者临床病理特征;检测患者入院时凝血四项及D-D水平,分析凝血四项、D-D水平与食管鳞癌患者临床病理特征的相关性。结果有淋巴结转移患者纤维蛋白原(FIB)、D-D水平高于无淋巴结转移者(P<0.05);有远端转移患者活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)短于无远端转移者,FIB、D-D水平高于无远端转移者(P<0.05);低分化患者D-D高于中/高分化者(P<0.05);经Logistic回归分析结果显示,FIB、D-D高表达与食管鳞癌患者淋巴结转移有关(P<0.05);APTT短、PT短、FIB及D-D高表达与食管鳞癌患者远端转移有关(P<0.05);D-D高表达与食管鳞癌患者低分化有关(P<0.05)。结论食管鳞癌患者凝血四项、D-D水平与淋巴结转移、远端转移、肿瘤分化程度等临床病理特征有关。
简介:【摘要】目的:在冠心病诊断中联合进行超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、脂蛋白(a)[Lp(a)]等指标,并分析其应用价值。方法:选取2019年1月-2022年1月,在我院治疗的60例冠心病患者。根据临床分类标准,将其分为急性心肌梗死组(AMI)18例、不稳定心绞痛组(UAP)22例、稳定性心绞痛组(SAP)20例,同时选取50名健康体检者作为对照组。比较各组的检测结果。结果:冠心病各组患者的hs-CRP、Lp(a)、D-D 水平均明显高于对照组(P<0.05),冠心病各组对比,AMI 组患者hs-CRP、Lp(a)、D-D 水平最高,其次为UAP 组患者,SAP 组患者最低,差异明显(P<0.05)。结论:冠心病患者存在hs-CRP、Lp(a)、D-D 水平异常升高情况,且不同类型患者升高幅度也有明显差异,可作为临床诊断鉴别的重要依据。