简介：目的：分析耳郭刺激抗衰老的疗效，寻求一种简便、安全的抗衰老的保健方法。方法：综合分析耳郭刺激与抗衰老的文献报道，从衰老与耳的关系，耳郭抗衰老的刺激方法、临床应用及机理研究等方面进行探讨。结果与结论：耳郭刺激通常选用与五脏相对应的耳穴心、肝、脾、肺、肾及内分泌、皮质下。耳郭刺激，尤其是耳穴贴压和耳郭按摩法，是简便有效的无创伤性保健、治疗方法，应当在抗衰老中起更大作用。

简介：目的：研究针刺足三里对D-半乳糖所致衰老小鼠抗衰老作用的机制。方法：三十只28周龄ICR系雌性小白鼠，随机分成对照组、模型组和针刺组。在光学显微镜下观察小肠粘膜形态学变4L；分别测定血清中超氧化物歧化酶（SuperoxideDismutase，SOD）活性和丙二醛（Malondialdehyde，MDA）含量。结果：针刺组SOD活性高于模型组和对照组，MDA含量低于模型组和对照组。模型组正常型绒毛比率减少，上皮细胞脱落再生加剧，肠绒毛萎缩；针刺组肠绒毛形态改善，肠上皮细胞异常减少。结论：针刺足三里能提高血清中SOD活性，减少MDA含量，改善肠绒毛形态，有助于延缓衰老过程。

简介：Therapiesthatcomplementfreeradicalscavengingareanimportantapproachfortreatingaginginthebrain.Inthepresentstudy,twoformulationsofmoxaconemoxibustionwereappliedatacupointsZusanli(ST36)andXuanzhong(GB39),andatacupointsBaihui(DU20)andGuanyuan(RN4),inD-galactose-inducedsenilemice.TheresultsrevealedthatmoxaconemoxibustionimprovedtotalsuperoxidedismutaseandCu/Zn-superoxidedismutaseactivityinthehomogenatesofthecerebraltissue,aswellasamelioratingdeficitsinneuronalmorphologyandneuronaldensityinthecerebralcortexandhippocampalCA3.Moxaconemoxibustionalsoenhancedlearningandmemoryfunctionsofsenilemice.MoxaconemoxibustionatZusanli,Xuanzhong,BaihuiandGuanyuanacupointscanthusbeusedtocomplementfreeradicalscavengers,withefficacythatisequaltothatofelectroacupunctureatZusanliandXuanzhong,andsuperiortothatofnimodipinetreatment.

简介：ThefruitsofPaulowniacatalpifoliaGongTongareusedasaChinesefolkherbalmedicineforthetreatmentofenteritis,tonsillitis,bronchitis,anddysentery,etc.OurpreviousstudyhasidentifiednewC-geranylatedflavanoneswithobviousanti-proliferativeeffectsinlungcancerA549cells.Inthepresentstudy,anewC-geranylatedflavone,paucatalinoneC(1)andfiveknownC-geranylatedflavanones(2-6)wereisolated.Inaddition,atotalof34C-geranylatedflavonoidsweredetectedbyHPLC-DAD-ESI-MS/MScouplingtechniquesfromtheCH_2Cl_2extractofP.catalpifolia.Futhermore,anti-agingeffectsofisolatedcompoundswereevaluatedinvitrowithprematuresenescent2BScellsinducedbyH_2O_2.PhytochemicalresultsindicatedthatP.catalpifoliawasanaturalresourceofabundantC-geranylatedflavonoids.Diplacone(3)andpaucatalinoneA(5)werethepotentanti-agingagentsintheprematuresenescent2BScellsinducedbyH_2O_2andtheC-geranylsubstituentmaybeanimportantfactorbecauseofitslipophiliccharacter.

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简介：AbstractAs human life expectancy continues to increase and the birth rate continues to decline, the phenomenon of aging is becoming more prominent worldwide. Therefore, addressing the problems associated with global aging has become a current research focus. The main manifestations of human aging are structural degeneration and functional decline of aging tissues and organs, quality of life decline, decreased ability to resist diseases, and high incidence rates of a variety of senile degenerative diseases. Thus far, no ideal treatments have been found. Stem cell (SC) therapies have broad application prospects in the field of regenerative medicine due to the inherent biological characteristics of SCs, such as their plasticity, self-renewal, and multidirectional differentiation potential. Thus, SCs could delay or even reverse aging. This manuscript reviews the causes of human aging, the biological characteristics of SCs, and research progress on age reversal.

简介：and Quarterly Journal of Economics).[5] The median age of authors in the 1980s and 1990s was 36. Scholars over age 50 when their studies are published are a minute fraction of all authors in these journals. Creative economics at the highest levels is mainly for the young. That is as true in the 1990s as it was in the 1960s,The evidence in section I documents the decline in productivity at the sample means. Information on the age-productivity relationship at the extremes of the sample is interesting in its own right and might help shed some light on the possible causes of the apparent decline in productivity with age. The simplest test compares productivity losses among the top early performers with that of the entire sample of economists at elite institutions. Among the top 10% of early producers the mean values of I1,Abstract--Economists' productivity over their careers and as measured by publication in leading journals declines very sharply with age. There is no difference by age in the probability that an article submitted to a leading journal will be accepted. Rates of declining productivity are no greater among the very top publishers than among others

简介：Whereasmuchhasbeenlearnedaboutage-relatedauditorychangesintheinnerear,relativelylittleisknownabouttheagingeffectsonthevestibularpartoftheinnerear-theperipheralvestibularsystem.Herewereviewrelevantliteraturewithregardtotheprevalenceofvestibulardysfunction,vestibularfunctionalandstructuralchangesintheelderly.Theprevalenceofvestibulardysfunctionincreaseswithage.Functionally,asageincreases,VEMPamplitudesdecrease,VEMPthresholdsincrease,VORgainofHITdecreases.Duetothecomplexityofthevestibularsystem,variationsinsubjectageandmeasurementtechniques,findingsinVEMPlatencyandcalorictestsareconflicting.Toaddressthis,adirectmeasureoftheperipheralvestibularsystemshouldbeapplied.Structurally,age-relatedlossinvestibularganglionandotoconiahavebeennoted;haircellchangesarenotwelldefined;whilesubcellularchangesremaintobeexplored.Defininghowtheonsetofvestibulardysfunctioncorrelateswithstructuraldegenerationwillofferinsightsintothemechanismsunderlyingvestibularaging.

简介：and Quarterly Journal of Economics).[5 The median age of authors in the 1980s and 1990s was 36. Scholars over age 50 when their studies are published are a minute fraction of all authors in these journals. Creative economics at the highest levels is mainly for the young. That is as true in the 1990s as it was in the 1960s,The evidence in section I documents the decline in productivity at the sample means. Information on the age-productivity relationship at the extremes of the sample is interesting in its own right and might help shed some light on the possible causes of the apparent decline in productivity with age. The simplest test compares productivity losses among the top early performers with that of the entire sample of economists at elite institutions. Among the top 10%26#37,the decline appears to be quite substantial. Between years 9-10 and 14-15 elite economists as a group lose 29 to 32%26#37

简介：Agingisamultifactorialprocesscharacterizedbydeteriorationsoffunctionalcapacityofvariousorgansandthewholebodyperformance.Exogenousmechanismforagingincludesonsetandprogressofvariousdegenerativediseases,whereasintrinsicmechanismisgovernedbycellulareventswhereincatabolicprocessesexceedthecapacityforrepairandrejuvenation.1Oxygenandnitrogencenteredreactivespecies(ROS)havebeenidentifiedtoplayakeyroleinboththeintrinsicandextrinsicdevelopmentofagingprocesses,termed"freeradicaltheoryofaging".2Duringthepasthalfofcenturymajorprogresseshavebeenmadeinboththeresearchofagingmechanismandclinicalpracticesinage-relateddiseasetreatmentandelderlycare,resultingasteadyimprovementoflongevityandanimpressiveexpansionoftheelderlypopulationamongindustrializedcountryandsomedevelopingcountries.Thistrendwilllikelygrowinthecurrentcentury.

简介：and Quarterly Journal of Economics).[5 The median age of authors in the 1980s and 1990s was 36. Scholars over age 50 when their studies are published are a minute fraction of all authors in these journals. Creative economics at the highest levels is mainly for the young. That is as true in the 1990s as it was in the 1960s,The evidence in section I documents the decline in productivity at the sample means. Information on the age-productivity relationship at the extremes of the sample is interesting in its own right and might help shed some light on the possible causes of the apparent decline in productivity with age. The simplest test compares productivity losses among the top early performers with that of the entire sample of economists at elite institutions. Among the top 10%26#37,the decline appears to be quite substantial. Between years 9-10 and 14-15 elite economists as a group lose 29 to 32%26#37

简介：Theprolongationoflifeexpectancyandthedrasticreductionoffertilityratearetheprimarycauseofanagingworld.Itisprojectedthattheelderly(above65)willincreasewithinthenext25yearsby82%,whereasthenewbornonlyby3%.Despitetheenormousmedicalprogressduringthepastfewdecades,thelastyearsoflifearestillaccompaniedbyincreasingillhealthanddisability.Theabilitytomaintainactiveandindependentlivingforaslongaspossibleisacrucialfactorforaginginhealthanddignity.Therefore,thepromotionofhealthyagingandthepreventionofdisabilityinmen,mustassumeacentralroleinmedicalresearchandmedicalpracticeaswellasintheformulationofnationalhealthandsocialpolicies.Effectiveprogramspromotinghealthandagingwillensureamoreefficientuseofhealthandsocialservicesandimprovethequalityoflifeinolderpersonsbyenablingthemtoremainindependentandproductive.Themostimportantanddrasticgenderdifferencesinagingarerelatedtoorgansandorsystemsdependantorinfluencedbyreproductivehormones.Indistinctiontothecourseofreproductiveaginginwomen,withtherapiddeclineinsexhormonesandexpressedbythecessationofmenses,agingmenexperienceaslowandcontinuousdeclineofhormones.Thisdeclineinendocrinefunctioninvolves:Adecreaseoftestosterone,dehydroepiandrosterone(DHEA),oestrogens,thyroidstimulatinghormone(TSH),growthhormone(GH),insulin-likegrowthfactor-1(IGF-1),andmelatonin.ThisdecreaseisconcomitantwithanincreaseofLHandFSH.Inadditionsexhormonebindingglobulin's(SHBG)increasewithageresultinginfurtherloweringtheconcentrationsoffreebiologicallyactiveandrogens.Interventionssuchashormonereplacementtherapymayprevent,delayoralleviatethedebilitatingconditionswhichmayresultfromsecondarypartialendocrinedeficiency.Primaryandsecondarypreventivestrategiessuchasthepromotionofasafeenvironment,healthylifestyleincludingp

简介：ＴａｓｋｓｆｏｒＣｈｉｎａ’ｓＡｇｉｎｇＰｒｏｇｒａｍｍｅＴｈｅｏｂｊｅｃｔｉｖｅｓｏｆＣｈｉｎａ’ｓａｇｉｎｇｐｒｏｇｒａｍｍｅａｒｅｔｏ“ｐｒｏｖｉｄｅｅｃｏｎｏｍｉｃｓｕｐｐｏｒｔ，ｍｅｄｉｃａｌａｎｄｈｅａｌｔｈｃａｒｅｓｅｒｖｉｃｅｓａｎｄ...

简介：and Quarterly Journal of Economics).[5 The median age of authors in the 1980s and 1990s was 36. Scholars over age 50 when their studies are published are a minute fraction of all authors in these journals. Creative economics at the highest levels is mainly for the young. That is as true in the 1990s as it was in the 1960s,The evidence in section I documents the decline in productivity at the sample means. Information on the age-productivity relationship at the extremes of the sample is interesting in its own right and might help shed some light on the possible causes of the apparent decline in productivity with age. The simplest test compares productivity losses among the top early performers with that of the entire sample of economists at elite institutions. Among the top 10%26#37,the decline appears to be quite substantial. Between years 9-10 and 14-15 elite economists as a group lose 29 to 32%26#37

简介：ThereisuptonownoconstitutivemodelinthecurrenttheoriesofCDMthatcouldgiveadescriptionforthedegradationofagingconcrete.Thetwointernalstatevariablesβandωareintroducedinthispaper.βiscalledcohesionvariableasanadditionalkinematicparameter,reflectingthecohesionstateamongmaterialparticles.ωiscalleddamagefactorformicro-defectssuchasvoids.ThenadamagemodelandaseriesofconstitutiveequationsaredevelopedonContinuumMechanics.Themodelproposedcouldgiveavaliddescriptionforthewhole-course-degradationofagingconcreteduetochemicalandmechanicalactions.Finally,thevalidityofthemodelisevaluatedbyanexampleandexperimentalresults.

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简介：ＰｏｐｕｌａｔｉｏｎＡｇｉｎｇａｎｄＣｏｎｔｒｏｌｏｆＰｏｐｕｌａｔｉｏｎＧｒｏｗｔｈＴｕＰｉｎｇＲａｐｉｄｐｏｐｕｌａｔｉｏｎａｇｉｎｇＷｉｔｈａｂｉｇｄｒｏｐｉｎｆｅｒｔｉｌｉｔｙａｆｔｅｒｔｈｅ１９７０ｓ，ｔｈｅｐｒｏｐｏｒｔｉｏｎｏｆｃｈｉｌ...

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