简介：<正>①NBA是强者的舞台,要想不被淘汰出局你必须付出百分之两百的努力,我就是这样。②但是并不是付出了就一定能有回报,您瞧,这不是吗?③人算不如天算,没想到更危险的还在后头,这一跤摔得可不轻啊。

简介：<正>NBA新赛季即将开战,各队老板都在挥舞着手中的票子招兵买马,以图来年雄起。能雄起还算值,雄了不起那才叫个冤啊……对球员来说也是几家欢喜几家愁,古话有云:"人挪活,树挪死",是真是假暂且不说,挪了还死,那我也不知道该说什么了。下面就来看看这些换了或没换新东家的爷们对新赛季做何感想。

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简介：石头,在地质学上被称为岩石.你知道石头是什么,又有什么用处吗？让我来用几个同音字为你讲一讲吧!石就是“拾”——石头随处可以捡到,有些还成为收藏品不知道你是否喜欢捡拾漂亮的石头,比如雨花石.其实石头在我们的生活中到处都是,几乎随处可以捡到,特别是在山谷、河滩,往往会有漂亮的“收藏品”等待着岩石迷们.那些有独特花纹且颜色美丽的石头在市场上价格不低,像玉石这样的石中精品更是价值不菲.

简介：Meridians'symptomsandsignsaretheimortantcontentofthetheoryofacupunctureandmoxibustion.Theytogetherwiththedescriptiononmeridians'travellingcoursesformthetheoreticalcoreofmeridiandoctrine.Thesemeridiansaremainlyreferredtothetwelveregular

简介：ShiChanwasbornintoatamilyofXianghuang.abranchofethnicManchuinBejing.in1938,In1956.ShibeganstudyingChinesePaintingundermastersWangZhujiuandLiKuchan.Shi.in1984.beganstudyingunderanothertwomasters-CuiZifanundZhuQizhan-ofCnincscpainting.shireccivedmuchhelpandguidancetromtheseinaster.

简介：OnJune31996,MinisterofElectricPowerShiDazhenacceptednews-coveringofBritain"FinancialTimes"residentreporterinBeijingTonyWalker,residentreporterinHongKongJohnRiddingandAsianEditorPeterMontagnon,andansweredtheirquestionsintheaspectsofthe9thFive-yearDevelopmentPlanningofChina’sElectricPowerandsomerelatedissues.

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简介：AbstractBackground:The incidence of idiopathic membranous nephropathy (IMN) has recently increased remarkably. Immune dysfunction caused by disordered intestinal flora might be an important factor affecting IMN. The Jian Pi Qu Shi Formula (JPQSF) shows promise in treating IMN. Here, we sequenced 16S rRNA genes to compare intestinal flora between patients with IMN and healthy persons. We also conducted a randomized controlled clinical trial to further compare the intestinal flora of patients with IMN treated with traditional Chinese medicine (TCM) and western medicine (WM).Methods:Among 40 patients with IMN treated at Department of Nephrology in Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine between July 2016 and December 2018, we compared 30 of them with 10 healthy persons (controls). The IMN group was randomly assigned to receive JPQSF (TCM) or immunosuppressant WM therapy in (n = 15 per group) for 6 months. Intestinal microbiota diversity was analyzed using alpha diversity and beta diversity. Intestinal flora that significantly differed between the groups was analyzed using MetaStat. The effects and safety of the therapies were determined based on the values for plasma albumin, 24-h urine protein excretion, serum creatinine, urea nitrogen, estimate glomerular filtration rate (eGFR), complete blood count, and liver enzymes. All data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) 20.0 statistical software.Results:Baseline characteristics did not significantly differ between the IMN and healthy groups, or the TCM and WM groups. After six months of treatment, 24-h urinary protein significantly declined in the TCM and WM groups (before and after treatment: 3.24 ± 1.74 vs. 1.73 ± 1.85 g, P < 0.05 and 3.94 ± 1.05 vs. 1.91 ± 1.18 g, P < 0.05, respectively). Plasma albumin was significantly increased in the TCM group (before vs. after treatment: 32.44 ± 9.04 vs. 39.99 ± 7.03 g/L, P < 0.05), but did not significantly change in the WM group (31.55 ± 4.23 vs. 34.83 ± 9.14 g/L, P > 0.05). Values for urea nitrogen, serum creatinine, and eGFR did not significantly change in either group. The alpha diversity index for intestinal flora differed between the IMN and healthy groups, and the TCM and WM groups. Comparisons of multiple samples (beta diversity) revealed differences in intestinal flora between the IMN and healthy groups, and the TCM and WM groups. The Metastat analysis findings showed that the main genera that differed between the IMN group before treatment and the healthy group were Christensenellaceae_R-7_group, Bifidobacterium (77), Dorea, Escherichia-Shigella, Parabacteroides, Bifidobacterium, and Coprococcus_3. After TCM therapy, the main differential genera were Butyricimonas, Bacteroides, Alistipes, and Lachnospira, and after WM therapy, these were Ruminococcus_2, Lachnospiraceae_ND3007_group, Lachnospira, Bifidobacterium, Alistipes, and [Eubacterium]_ventriosum_group.Conclusion:Patients with IMN might have disordered intestinal flora, and JPQSF can regulate intestinal flora in patients with IMN.

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简介：本研究探讨四嗪二甲酰胺（ZGDHu-1）诱导白血病细胞株SHI-1凋亡作用的机制。以不同浓度的ZGDHu-1在体外培养SHI-1细胞,用细胞形态学、DNA凝胶电泳、DNA含量及细胞周期分析、Annexin-V/PI双标记和Ho-echst33258荧光染色等分析细胞凋亡。用Rh123/PI测定线粒体跨膜电位（ΔΨm）,用流式细胞术检测ZGDHu-1诱导SHI-1细胞凋亡过程中bcl-2、bax、p53、Fas蛋白和线粒体膜蛋白的表达变化。用RT-PCR观察经ZGDHu-1作用后SHI-1细胞bcl-2、bax、p53基因表达改变;同时利用实时荧光PCR定量检测端粒酶hTERT-mRNA表达的变化。结果表明：ZGDHu-1能诱导SHI-1细胞凋亡,呈作用时间和剂量的量效关系,出现典型的细胞形态改变,DNA片段化,亚G1峰检出并显著增加;Annexin-V/PI和Hoechst33258荧光染色后细胞发生凋亡的特征性改变。SHI-1细胞经不同浓度的ZGDHu-1体外培养后,bcl-2基因和蛋白有所下调,但主要是bax基因和蛋白上调,导致bax/bcl-2比值明显增高,p53基因和蛋白与Fas蛋白表达也上调,均呈剂量依赖性。随ZGDHu-1作用浓度的增加,ΔΨm下降,而线粒体膜蛋白表达显著升高,端粒酶hTERT-mRNA的表达显著下调。结论：ZGDHu-1通过上调p53基因、bax基因和bax/bcl-2比值,使线粒体跨膜电位显著下降的线粒体通路是ZGDHu-1诱导细胞凋亡的途径之一,Fas也参与其中,端粒酶有可能是其抗肿瘤的作用靶点。

简介：摘要目的分析阿帕替尼对急性单核细胞SHI-1生长抑制作用及VEGF表达的影响。方法采用四甲基偶氮唑盐(MTT)法检测不同浓度的阿帕替尼作用不同时间段下SHI-1细胞的存活率。酶联免疫吸附法（ELISA）检测不同浓度阿帕替尼作用后SHI-1细胞培养上清VEGF浓度。结果不同浓度阿帕替尼分别作用24h与48h后与空白对照组相比，对SHI-1细胞增殖有明显抑制作用（P<0.05）；SHI-1细胞培养上清VEGF浓度明显下降，差异具有统计学意义（P<0.05）。结论阿帕替尼对SHI-1的细胞增殖有明显抑制作用，此外，SHI-1细胞株高表达VEGF，阿帕替尼可减少VEGF分泌。

简介：ThisarticleverifiedthattheTustatementionedintheoracleinscriptionswastheXiapeopleaftertheXiaDynastyhadbeenconqueredbyTang,thefirstkingoftheShangDynastymc.a.16thcenturyB.C.ThestateofXia,whichoriginatedfromYu,wasentitled"XiaHou";itskingwashencecalled"XiaHouDi"(EmperorofXiaHou),e.g."XiaHouDiQi".TheXiapeople,togetherwiththeYin(Shang)people,andtheZhoupeople,weretheso-called"peopleofSanDai"(ThreeDynasties).Asmentionedin"Lunyu,Bayi",theyfoundedthestates,withtheXiapeoplebeingassociatedwiththepine,theYinpeoplewiththecypress,andtheZhoupeoplewiththechestnut.