简介：Purpose:Arandomized,controlledtrialwasconductedtodeterminewhethera6-weeklowcaloriedietandaerobicexerciseinterventioncouldaltermetabolicsyndrome(MetS)riskfactorsinpre-pubescentobeseChinesechildren.Methods:Thesubjectswererandomizedintodietandexercise(DE)andcontrol(C)groups.TheDEgroupingested1600-2000kcal/dayadjustedtoeachparticipant’sbasalmetabolicrate,andengagedinhigh-volumeaerobicexercise(6days/week,twicedaily,for3hpersession)for6weeks.Atotalof215obesechildrenbetweentheagesof11and13yearswererecruitedintothestudy,with167subjects(DE,n=95;C,n=72)completingallphases.Pre-andpost-studymeasuresincludedbodyweight,bodymassindex,waistcircumference,bodyfatpercentage,bloodpressureandotherMetS-relatedmarkersfromfastingbloodsamples(serumcholesterol,triglycerides,insulin,andglucose).Results:Comparedtocontrols,theDEsubjectsexperiencedsignificantlyreducedlevelsforalloutcomemarkers(p<0.05),exceptforfastingbloodglucoseinboys(p=0.09).Conclusion:Anintensive,6-weekdietandexerciseinterventionhadfavorableeffectsinalteringMetSriskfactorsinobeseChinesechildrenaged11to13.

简介：1.BiochemicalstructureandmolecularactivityofmeldoniumMeldonium(commercialnameMildronate)wasoriginallysynthesizedinthemid-1970sattheInstituteofOrganicSynthesisoftheLatvianSovietSocialistRepublicAcademyofSciences.Thechemicalstructureofthiscompound(3-(2,2,2-

简介：1.TheendocannabinoidsysteminobesityandmetabolicdisordersAsobesityandassociatedmetabolicdisorders,suchastype2diabetesanddyslipidemia,arebecomingoneofthemostserioushealthproblemsworldwide,developmentofeffectivetherapiesisahighpriority.Inthesearchfortreatments,therecentlydiscoveredendocannabinoidsystem(ECS)hasbeguntogarnerattention,andawealthofresearchisnowfocusing

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简介：Children(5-12years)andadolescents(13-19years)withDownsyndrome(DS)possessasetofhealth,anatomical,physiological,cognitive,andpsycho-socialattributespredisposingthemtolimitationsontheirphysicalfitnessandphysicalactivity(PA)capacities.Thepaucityofstudiesandtheirconflictingfindingspreventaclearunderstandingand/orsubstantiationoftheselimitations.Thepurposeofthisarticlewastoreviewthemeasurement,determinantsandpromotionofphysicalfitnessandPAforyouth(i.e.,childrenandadolescents)withDS.TheexistingbodyofresearchindicatesthatyouthwithDS:1)havelowcardiovascularandmuscularfitness/exercisecapacity;2)demonstrateagreaterprevalenceofoverweightandobesity;3)alargeproportiondonotmeettherecommendedamountofdailyaerobicactivity;and4)theirPAlikelydeclinesthroughchildhoodandintoadolescence.Futureresearchshouldfocuson:1)strengthtestingandtrainingprotocols;2)methodologiestodeterminePAlevels;and3)practicalinterventionstoincreasePA.

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