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简介：Objective:Toobservetheclinicalefficacyofacupuncture-moxibustionintreatingAlzheimer’sdisease(AD).Methods:Forty-eighteligibleADpatientswereenrolledtoreceiveacupunctureplusherb-partitionedmoxibustion.Mini-mentalstateexamination(MMSE)wasadoptedforevaluationbeforeandafterintervention,andthetherapeuticefficacywasobserved.Results:Afterintervention,theMMSEscorechangedsignificantly(P<0.01),andthetotaleffectiveratewas83.3%.Conclusion:Acupuncture-moxibustioncansignificantlyimprovethecognitivefunctionofADpatients,beneficialtothegeneralpromotionofthequalityoflife.

简介：Alzheimer’sdisease(AD)isoneofthemostdevastatingdiseasesaffectingthelifeandhealthofagingpopulation.TwohallmarksofADaresenileplaquesandneurofibrillarytangles,andADiswellknownforthemassivelossofneuronsandimpairedcognitivefunctionsespeciallymemoryloss.Despiteextensivesearchforeffectivetreatment,available

简介：Despitetheadvancesincombinatorialorsyntheticchemistryandbioinformatics,recentliteraturehasdemonstratedtherelevanceofnatureandbiomassasasourceofnewmoleculestotreatdifferentpathologies,i.e.,bioactivecompoundsobtainedfromEcteinascidiaturbinatetotreatsometypesofcancerorrapamycinfromStreptomyceshygroscopicustopreventorganrejectionaftertransplant.Thistrend

简介：CurrentevidenceshowsthatapolipoproteinE(APOE),apolipoproteinCI(APOC1)andlowdensitylipoproteinreceptor-relatedprotein(LRP)variationsarerelatedtolate-onsetAlzheimer’sdisease.However,itremainsunclearifgeneticpolymorphismsinthesegenesareassociatedwithcognitivedeclineinlate-onsetAlzheimer’sdiseasepatients.Weperformeda30-monthlongitudinalcohortstudytoinvestigatetherelationshipbetweenAlzheimer’sdiseaseandAPOE,APOC1,andLRP.Inthisstudy,78ChineseHanpatientswithlate-onsetAlzheimer’sdiseasewererecruitedformGuangxiZhuangAutonomousRegioninChina.APOE,APOC1,andLRPgenotypingwasperformedusingpolymerasechainreaction-restrictionfragmentlengthpolymorphisms.TheMini-MentalStateExaminationandClinicalDementiaRatingScalewereusedtoassesspatients’cognitivefunction.Aftera30-monthfollow-upperiod,wefoundasignificantreductioninMini-MentalStateExaminationtotalscore,ahigherproportionofpatientsfulfillingcognitiveimpairmentprogressioncriteria,andahigherproportionofAPOC1H2carriersinAPOEε4carrierscomparedwithnon-carriers.Inaddition,theAPOEε4allelefrequencywassignificantlyhigherinthecognitiveimpairmentprogressiongroupcomparedwiththenon-cognitiveimpairmentprogressiongroup.Inconclusion,APOEε4playsanimportantroleinaugmentingcognitivedecline,andAPOC1H2mayactsynergisticallywithAPOEε4inincreasingtheriskofcognitivedeclineinChinesepatientswithlate-onsetAlzheimer’sdisease.

简介：曾经有朋友向我咨询关于猫的问题：你说那些金吉拉、波斯猫、美国短毛猫或者布偶猫什么的，真能拿耗子么？我其实真没见过纯种宠物猫是怎么逮耗子的，但以基本靠蒙的态度回答：逮耗子是猫的天性，纯种宠物猫也应该会拿耗子吧……其实，以我个人的观察，虽然大家一致认为狗的驯化比猫更彻底，但现实中有许许多多的猫的确丧失了逮耗子的能力，我曾亲眼见到猫被耗子“调戏”的例子，你在网上随便一搜猫怕耗子的新闻，那多得简直令人发指。

简介：动物之于人类是什么？动物福利是什么7你看，动物园里的那头熊可真傻!为了一根虾条就能摆出那么蠢荫的动作，笑死我啦，哈哈哈!过来过来，我亲爱的宝贝儿!“麻麻”出差几天不见都想死你了!这是我新给你买的金枪鱼罐头，我就知道你最爱吃了!快，给“麻麻”亲亲。不就是一头猪么，白刀子进，红刀子出，虽然杀猪时的嚎叫还有那么点吓人，但新鲜猪肉做的刨猪汤还是很美味的。

简介：作为一名从任天堂红白机时代就开始玩游戏的人来说，我从未觉得一款“反人类”的游戏是如此的好玩儿，以至于我乐此不彼地想要去了解关于各种致病微生物的一切。或许你已经猜到了，这个游戏正是《瘟疫公司》，玩家必须在游戏里挖空心思制造一场瘟疫，尽可能短时间消灭掉地球上所有的人。

简介：C/S和B/S是如今软件开发模式技术架构的两大主流软件结构。这两项技术已被世界各国所掌握并充分利用,国内各大软件公司利用C/S和B/S技术开发出的产品和平台也很多。这两种软件都有自己广泛的市场和客户群体。它们各有优劣势,也都各有用途。几乎都被普遍应用于各个网络平台上。这里简要介绍一下这两种结构并作一下简单比较。

简介：NatsumeSōseki(1867-1916)sufferedfromcyclicmentaldepressionsthroughhislife,anditwaswhenhewasinthestateofthemostterribleonethathestartedhiscareerasawriterbywritingIAmaCat(1905-1906).TherearesomeevidencebyhiswifeandfriendsthatSōseki’sconditionofdiseasedramaticallyimprovedduringitsserializationonamagazine,andthewriterhimselfadmitedhumorouslyintheprefaceofotherworkthatitwashisdepressionandmaniathatenabledhimtoproduceIAmaCatandotherearlyworks.Thispaperaimsatdescribingtheprocesshowhisactofnarratinghadtherapeuticeffectsonhisstateofmindfocusingontheconstructionofcomplicitousrelationshipbetweenanimpliedauthorandreadersintheworkbytheuniquefunctionsofthefirst-‘person’narrator:ACat.Amongothers,IwillconsidertheinfluenceofLaurenceSterne’sTristramShandy(1759-1767),whichSōsekiintroducedtoJapanforthefirsttime,bydiscussingthefrequentuseofmetalepsisthatthetwoworkshaveincommon.

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简介：Esteartículoanalizódospalabrasordinarias（síyno）,aunqueestaspalabrasusamosnormalementeenlavidadiaria.Laautorasepercatódeladiferenciadelusodeestasdospalabrasentrediferentespaíses,yinvestigólacausadesdelaperspecivalingüística.

简介：在这份报纸，在范围的稳定的homotopy组的homotopy元素的一个新家庭由n2m5and3s代表了s

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简介：<正>TheJOURNALOFANCIENTCIVILIZATIONS(JAC)ispublishedannuallybytheInstitutefortheHistoryofAncientCivilizations(NortheastNormalUniversity,Changchun,JilinProvince,People’sRepublicofChina).JACprovidesaforumforthediscussionofvariousaspectsoftheculturalandhistoricalprocessesintheAncientNearEasternandMediterraneanworld,encompassingstudiesofindividualcivilizationsaswellascommonelements,contactsandinteractionsamongthem(e.g.,insuchtraditionalfieldsasAssyriology,

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简介：<正>AttheinvitationoftheChineseAssociationforInternationalUnderstanding(CAFIU),a6-memberAustralianandNewZealand’sRotaryClubdelegationvisitedChinafromSeptember23toSeptember27.AsastaffmemberofCAFIU,Ihadthehonortotakepartinthereceptionofthedelegationthroughoutthistrip.

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