简介：目的：探讨穴位埋线治疗溃疡性结肠炎的作用机制。方法：将18只SD大鼠随机分为3组：正常对照组、模型组、穴位埋线组,每组6只。除正常对照组未行造模外,其余2组大鼠均采用三硝基苯磺酸（TNBS）造摸。模型组不予干预,正常饮食,穴位埋线组于＂上巨虚＂＂天枢＂＂大肠俞＂处进行穴位埋线治疗。治疗15d后观察大鼠的腹泻、便血症状和结肠病理组织学改变,用westernblot法检测大鼠脾淋巴细胞核因子-κBp65（NF-κBp65）及相关信号分子β2肾上腺素受体（β2AR）蛋白的表达。结果：穴位埋线组的大鼠腹泻、黏液脓血便症状得到较快控制,大鼠黏膜组织损伤明显改善;与正常对照组相比,模型组大鼠脾淋巴细胞NF-κBp65增多（P〈0.01）,β2AR的表达减少（P〈0.01）,两组差异有统计学意义;与模型组比较,穴位埋线组大鼠脾淋巴细胞NF-κBp65减少（P〈0.01）,而β2AR的表达增多（P〈0.01）,两组脾淋巴细胞NF-κBp65和β2AR的表达存在明显差异。结论：穴位埋线治疗实验性结肠炎有明显效果,其作用机制可能是通过调节NF-κBp65及相关信号分子β2AR,从而发挥治疗作用。

简介：目的:探讨穴位埋线治疗溃疡性结肠炎的作用机制。方法:将18只SD大鼠随机分为3组:正常对照组、模型组、穴位埋线组,每组6只。除正常对照组未行造模外,其余2组大鼠均采用三硝基苯磺酸(TNBS)造摸。模型组不予干预,正常饮食,穴位埋线组于"上巨虚""天枢""大肠俞"处进行穴位埋线治疗。治疗15d后观察大鼠的腹泻、便血症状和结肠病理组织学改变,用westernblot法检测大鼠脾淋巴细胞核因子-κBp65(NF-κBp65)及相关信号分子β2肾上腺素受体(β2AR)蛋白的表达。结果:穴位埋线组的大鼠腹泻、黏液脓血便症状得到较快控制,大鼠黏膜组织损伤明显改善;与正常对照组相比,模型组大鼠脾淋巴细胞NF-κBp65增多(P<0.01),β2AR的表达减少(P<0.01),两组差异有统计学意义;与模型组比较,穴位埋线组大鼠脾淋巴细胞NF-κBp65减少(P<0.01),而β2AR的表达增多(P<0.01),两组脾淋巴细胞NF-κBp65和β2AR的表达存在明显差异。结论:穴位埋线治疗实验性结肠炎有明显效果,其作用机制可能是通过调节NF-κBp65及相关信号分子β2AR,从而发挥治疗作用。

简介：目的：探讨电针百会、足三里治疗抑郁症的免疫机制。方法：将84例患者随机分为电针观察组、电针对照组、药物对照组,每组28例。电针观察组穴取百会、足三里;电针对照组穴取太冲、三阴交、内关、神门;药物对照组给予百优解口服。在治疗前后分别用汉密尔顿抑郁量表（HAMD）评分,采用酶联免疫分析法（ELISA）检测患者血清中白细胞介素1（IL-1β）、白细胞介素6（IL-6）、肿瘤细胞坏死因子-α（TNF-α）的水平。结果：与治疗前比较,各组患者治疗后HAMD评分均显著降低（均P〈0.01）。电针观察组痊愈2例,显效19例,有效5例,无效2例;电针对照组分别为0例、16例、12例、0例;药物对照组分别为1例、17例、7例、3例,临床疗效等级分布提示电针观察组有较好的疗效（P〈0.05）;3组患者血清IL-1β、IL-6水平均较治疗前显著降低（P〈0.05,P〈0.01）;血清TNF-α有所降低,但无统计学意义。结论：电针观察组疗效优于电针对照组和药物对照组;3种治疗方法都能清除炎性细胞因子IL-1β及IL-6,从而改善抑郁症状。

简介：DENGMoumou,female,47yearsold,ateacher.Shecametoseethedoctoron5November,2007.ChiefComplaints:theherpeszosterappearedontheleftlowerlimbandpudendumfor24days.Historyofpresentillness:inSeptember2001,thepatienthadnoobviousinducement,rightfootswelledgraduallyextendedtothethigh;aftertheleftfootswelledgraduallyextendedtothethigh,pittingedema,absenceoftenderness,activitywasslightlyslow.ShewasexaminedinthePeople'sHospitalofMunicipality,withoutdefinitediagnosisandsymptomatictreatment,andleftthehospital.Thewholebodyswelledafteramonth,chestoppressionandshortnessofbreathcouldnotfallintosleep,andthenshewashospitalizedintheFirstSubsidiaryHospitalofXinjiangMedicalUniversity.Shewasconsideredtheleftvenaeiliacacommunisstraitnessorobturate,tookoperationthethrombus.Thepaunchedexplorationwasfoundwithperitoneumincrassation.Thediagnosisis'peritoneumsclerosisofconjunctivetissue'.Shewasadministeredhormone,antiinflammatory,fluidinfusion,anticoagulation,theswellingdecreased,andshelefthospital,tookorallyHydroprednisoneandFurosemidelongterm.ShecametoZhongshanHospitalofShanghaiin2003,receivingthesametreatment,theHydroprednisonegraduallyreduced.InMarch2006,theswellingdisappeared,andshestoptookorallyHydroprednisone.ShetookorallyFurosemideahalftableteveryday.InSeptember2007,feelingchestoppression,shewashospitalizedinthePectoralofMunicipality.Thehydrothoraxwasfound.Thedoctorabstractedhydrothorax4000cc.Shewasdiagnosedthephthisic.TheasciteswasdetectedthroughabdominalB-ultrasound,withoutbeingpumpedascitesduetothefrailofpatient.ShetookoralHydroprednisone30mgeveryday,andshereturnedhome.HerabdomengraduallyswelledinearlyOctober.Theherpesandperineumwerefoundonthecoccyxon12Octoberwithoutpain.Thelocialcliniqueandtheherpeszosterwerediagnosised.Shetookoral

简介：Apatient,female,aged65years,paidhervisiton18th,January,2008.Shecomplainedofedema,sorenessandheavinessofrightsideoflowerlimbfor9years,