简介：Mitoxantrone,aclinicallyusefulantitumourantibioticforleukaemiaandbreastcancer,hasreceivedmoreattentions.Inthispaper,theinteractionbetweenmitoxantroneandcalfthymusDNAisinvestigatedbyRamanandfluorescencespectroscopies,andthebindingsiteofmitoxantronetocalfthymusDNAisexplored.TheresultsshowedthatmitoxantroneinteractswithcalfthymusDNAbasesbytheintercalationofanthracyclineintothebasepairplaneofadenine(A)andthymine(T),anditresultsinthedisruptionofthehydrogenbondsbetweencalfthymusDNAbases,andthusthecalfthymusDNAdouble-strandcanbedisruptedintotheB-formDNAdouble-strandsegments.

简介：OpticalmethodsandMTTmethodareusedtocharacterizetheantiproliferationeffectofantitumordrug9-aminoacridine(9AA)withandwithoutsilvernanoparticles.IntracellularsurfaceenhancedRamanscattering(SERS)spectraandfluorescentspectraof9AAindicatetheformof9AAadsorbedonthesurfaceofsilvernanoparticles.AlthoughbothsilvernanoparticlesandantitumordrugcaninhibitthegrowthofHelacells,silvernanoparticlescanslowdowntheantiproliferationeffectonHelacellsatlowconcentrationofantitumordrugs.Ourexperimentalresultssuggestthatsilvernanoparticlesmayserveasslow-releasedrugcarriers,whichisimportantinantitumordrugdelivery.

简介：Thereappeartobethreeprincipleforcesdrivingthefutureofnewdrugdevelopment:under-standingthegenome-transcrip-tome-protemecorrelations,under-standingandmappingproteinposttrans-lationalmodification(PTM)pathways,andintegrationofmassspectrometry(MS)techniquesintoroutineproteinidentificationandcharacterization.