简介：

简介：

简介：目的探讨支气管扩张合并阻塞性通气功能障碍患者的肺泡灌洗液中可溶性晚期糖基化终末产物受体水平的临床意义.方法选取支气管扩张患者共８０例,采用酶联免疫吸附试验(ELISA)方法检测患者纤维支气管镜肺泡灌洗液中sRAGE水平,使用方差分析法对结果进行比较和分析.结果一组患者肺泡灌洗液sRAGE水平高于二组,差异有统计学意义(F＝３０．４８,P＜０．００１).直线相关分析结果显示,一组sRAGE水平与一秒用力呼气容积占预计值百分比(FEV１％)呈负相关(r＝－０．７３８,P＜０．０５).结论支气管扩张患者阻塞性通气功能障碍患者的sRAGE水平越高说明病情越重.关键词支气管扩张;支气管肺泡灌洗液;可溶性晚期糖基化终末产物AbstractObjectiveToinvestigatetheclinicalsignificanceofsolubleadvancedglycationendproductsreceptor(sRAGE)inthetreatmentofthepatientswithbronchialdilatationandobstructiveventilationdysfunction．Methodsatotalof８０patientsinourhospital,SRAGElevelsinpatientswithalveolarlavagefluidweredetectedbyenzymelinkedimmunosorbentassay(ELISA),andtheresultswerecomparedandanalyzedbyusingthevarianceanalysismethod．ResultsthelevelofsRAGEinagroupofpatientswithalveolarlavagefluidwashigherthanthatinthegroup,thedifferencewasstatisticallysignificant(F＝３０．４８,P＜０．００１)．LinearcorrelationanalysisshowedthatthelevelofsRAGEwasnegativelycorrelatedwiththepercentageofforcedexpiratoryvolumeinonesecond(FEV１％)(P＜０．０５,r＝－０．７３８)．ConclusionthehigherthelevelofsRAGEinpatientswithobstructiveventilationdysfunctioninpatientswithbronchialdilatation,themoreimportantitis．Keywordsbronchialdilatation;bronchoalveolarlavagefluid;solubleadvancedglycationendproducts中图分类号R５６２．２文献标识码B文章编号１００８－６３１５(２０１５)１２－１２８９－０１