学科分类
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8 个结果
  • 简介:TheBIONISnetworkwassetupinspring2002byProf.GeorgeJeronimidis,Prof.JulianVincentandPhilSheppard.Membershipisnowover300,withmembersfromacademiaandindustryinmorethan40countries.ThemissionofthenetworkistopromotetheapplicationofBiomimeticsinproductsandservicesanditsuseineducationandtraining.ItiscurrentlysupportedbySwedishBiomimetics3000?andhostedbytheUniversityofReading.

  • 标签: BIONIS网络 仿生学 研究项目 实验
  • 简介:Anewmethodwasdescribedforusingarecurrentneuralnetworkwithbiasunitstopredictcontactmapsinproteins.Themaininputstotheneuralnetworkincluderesiduespairwise,residueclassificationaccordingtohydrophobicity,polar,acidic,basicandsecondarystructureinformationandresidueseparationbetweentworesidues.Inourwork,adatasetwasusedwhichwascomposedof53globulinproteinsofknown3Dstructure.Anaveragepredictiveaccuracyof0.29wasobtained.Ourresultsdemonstratetheviabilityoftheapproachforpredictingcontactmaps.

  • 标签: 循环神经网络 蛋白质 预测 血红素 三维结构
  • 简介:Inthepost-genomicbiologyera,thereconstructionofgeneregulatorynetworksfrommicroarraygeneexpressiondataisveryimportanttounderstandtheunderlyingbiologicalsystem,andithasbeenachallengingtaskinbioinformatics.TheBayesiannetworkmodelhasbeenusedinreconstructingthegeneregulatorynetworkforitsadvantages,buthowtodeterminethenetworkstructureandparametersisstillimportanttobeexplored.Thispaperproposesatwo-stagestructurelearningalgorithmwhichintegratesimmuneevolutionalgorithmtobuildaBayesiannetwork.Thenewalgorithmisevaluatedwiththeuseofbothsimulatedandyeastcellcycledata.Theexperimentalresultsindicatethattheproposedalgorithmcanfindmanyoftheknownrealregulatoryrelationshipsfromliteratureandpredicttheothersunknownwithhighvalidityandaccuracy.

  • 标签: gene REGULATORY networks TWO-STAGE learning ALGORITHM