简介：植物蛋白质蛋白质相互作用网络没被大规模实验识别了。以便更好在米饭理解蛋白质相互作用，预言的米饭Interactome网络(PRIN；http://bis.zju.edu.cn/prin/)介绍76,585个预言的相互作用包含5,049米饭蛋白质。在印射米饭的genomic特征以后(去注解，subcellular本地化预言，和基因表示)，我们发现一个注解得好、生物学上重要的网络是足够富有的在高顺序的生物系统以内捕获许多重要功能的连接，例如小径和生物进程。而且，我们作为例子拿了疯盒子的包含域的蛋白质和生理节奏的节奏发信号小径证明功能的蛋白质建筑群和生物小径能有效地在我们的预言的网络被扩展。在PRIN的扩展分子的网络更加改进了这些分析的能力集成存在知识并且提供新奇卓见进基因和基因网络的功能和协作。

简介：Computationalanalysisisessentialfortransformingthemassesofmicroarraydataintoamechanisticunderstandingofcancer.Herewepresentamethodforfindinggenefunctionalmodulesofcancerfrommicroarraydataandhaveappliedittocoloncancer.First,acoloncancergenenetworkandanormalcolontissuegenenetworkwereconstructedusingcorrelationsbetweenthegenes.Thenthemodulesthattendedtohaveahomogeneousfunctionalcompositionwereidentifiedbysplit-tingupthenetwork.Analysisofbothnetworksrevealedthattheyarescale-free.Comparisonofthegenefunctionalmodulesforcoloncancerandnormaltissuesshowedthatthemodules’functionschangedwiththeirstructures.

简介：miRNAsarenon-codingsmallRNAsthatinvolvediversebiologicalprocesses.Untilnow,littleisknownabouttheirrolesinplantdroughtresistance.Physcomitrellapatensishighlytoleranttodrought;however,itisnotclearaboutthebasicbiologyofthetraitsthatcontributeP.patensthisimportantcharacter.Inthiswork,wediscovered16droughtstress-associatedmiRNA(DsAmR)familiesinP.patensthroughcomputationalanalysis.DuetothepossiblediscrepancyofexpressionperiodsandtissuedistributionsbetweenpotentialDsAmRsandtheirtargetinggenes,andtheexistenceoffalsepositiveresultsincomputationalidentification,thepredictionresultsshouldbeexaminedwithfurtherexperimentalvalidation.WealsoconstructedanmiRNAco-regulationnetwork,andidentifiedtwonetworkhubs,miR902a-5pandmiR414,whichmayplayimportantrolesinregulatingdrought-resistancetraits.Wedistributedourresultsthroughanonlinedatabasenamedppt-miRBase,whichcanbeaccessedathttp://bioinfor.cnu.edu.cn/ppt_miRBase/index.php.OurmethodsinfindingDsAmRandmiRNAco-regulationnetworkshowedanewdirectionforidentifyingmiRNAfunctions.