简介：闲聊其实是很好的打开话题的方式,如果你看过一部好看的电影或读过一本不错的书,你就可以和别人谈一谈。研究表明,你用自然的方式闲聊,可能会让自己变得更加快乐。下面就来看看闲聊是怎样帮助我们打开话题的。Smalltalkandchitchat1aretheshortconversationswehaveatpar-ties,whilewewaitinlineatthestoreorfamilyevents.Sometimeswe

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简介：ThesurvivalanddevelopmentofSMEs(smallandmediumenterprises)isanimportantissuefortheChineseeconomy.Inparticular,businesssuccessioninSMEsisapersistentissue.Businesssuccessioninvolvesselectionofasuccessor,assetinheritance,transferofmanagementrights,accumulationofbusinessconnectionsandtechnologysuccession,andsoforth.Thisallrequiressmoothexecutionofabusinesssuccessionplan.However,manySMEsdonothaveabusinesssuccessionplan,noraretheypreparingone.Ourtaskistoexplorethereasonsthesepreparationsarenotbeingmade.Here,thepurposeofourresearchistogetapictureofthestatusofpreparationsforbusinesssuccessioninSMEsinChina,andtheactualcircumstancesofsuccession,basedontheresultsofafact-findingsurveyofChineseSMEs,andatthesametimebringtothesurfacetheprimaryfactorswhichinfluencepreparationsandplans.Theresultsoftheanalysisshedlightonthestatusofbusinesssuccessionpreparations,successor’sawarenessofissues,decisionmaking,andsoon.Thissurveyhighlightstheawarenessofbusinesssuccessionamongbusinessmanagers.

简介：Nowadaysinternationalizationisnolongeraluxuryforcompaniesandbecomesanecessityinordertosurviveinthemarketandensureitsdurabilityovertime.Thisjustifiesthestructureofainternationalizationplan(IP)forasmallcompany(SEC),inordertomodifyitsvaluecurveagainstthecompetitionandguaranteeasustainedgrowthdevelopmentinnewmarkets.Thispaperpresentsastrategicanalysisofasmallconstructioncompanydedicatedtotheelaborationoffinishesforwalls,floors,andconcretearchitecture.Asituationalanalysiswascarriedouttoseewhatwouldbethemostappropriateinternationalstrategyforthecompany.Tools,suchas:(a)SWOT(strengths,weaknesses,opportunities,threats)Analysis,(b)PEST(political,economic,social,andtechnological)Analysis,(c)InternalFactorsEvaluationMatrix(IFE),and(d)ExternalFactorsEvaluationMatrix(EFEAssessmentMatrix),wereusedtoidentifythecurrentstandingoftheSEC.ThecanvasmodelandthecompetitiveprofilematrixwereusedtomaketheconnectionwiththestrategicpositionoftheSECagainstthedesireofinternationalization.Likewise,ananalysisoftheexternalfactorswascarriedoutshowingasignificantgrowthof4.6%inthespecializedsub-sector,aswellasatensebusinesslandscapedrivenbythepoliticalsituationbetweenMexicoandtheUnitedStates.

简介：AIMTo在intraocularscattering.METHODSSixty上在小切口的lenticule抽取(微笑)和它的效果以后调查帽子形态学--经历微笑的33个病人的五只眼睛被注册。除了常规评估，Fourier域光连贯断层摄影术被用来在1d调查帽子厚度，1wk，1并且3mo手术后地。散布的光优秀包括调整转移函数截止频率，Strehl比率，光优秀分析系统(OQAS)值，和目的索引(OSI)，用OQAS.RESULTSCap厚度被评估从1d减少了到1wk(P<0.001)，但是仍然保持比120的打算的厚度高

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简介：Givenanon-equidistantsequenceoranequidistantserieswithoneormoreoutliers,agreyinterpolationapproachconsideringthetimelagsisestablishedforproducingthemissingdataorcorrectingtheabnormalvalues.Toaccomplishthis,anewgreyincidencemodel,calledthegreydynamicincidencemodelGDIM(t),isconstructedfordeterminingwhetherthefactorsareeffectivetotheknownfactorandwhatthetimelagisbetweenausefulfactorandthespecifiedsequence.BasedontheresultsoftheGDIM(t)model,twoprogrammingproblemsaredesignedtoobtaintheupperandlowerboundsoftheunknownorabnormalvalueswhichareregardedasgreynumbers.Thesolutionsbasedontheparticleswarmoptimization(PSO)forthenonlinearprogrammingproblemsaregiven.Toexplainhowitcanbeusedinpractice,thisnewgreyinterpolationapproachisappliedtocorrectanabnormalvalueinthesequenceofanagricultureenvironmentproblem.

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简介：Background:Climatechangetriggeredmanystudiesshowingthattrendsandeventsofenvironmentalconditionscanreducebutalsoaccelerategrowthatthestandandindividualtreelevel.However,itisstillratherunknownhowclimatechangemodifiesthegrowthpartitioningbetweenthetreesinforeststands.Methods:Basedonlong-termgirth-tapemeasurementsinmaturemonospecificandmixed-speciesstandsofNorwayspruce(Piceaabies(L.)Karst.)andEuropeanbeech(FagussylvaticaL.)wetracedtheeffectoftheseveredroughtsin2003and2015fromthestand-downtothetreelevel.Results:StandgrowthofNorwaysprucedecreasedbyabout30%intheonce-in-a-centurydrought2015,whileEuropeanbeechwasmuchmoredroughtresistant.Wateravailabilitygenerallyamplifiedsize-asymmetricgrowthpartitioning.EspeciallyincaseofNorwaysprucewateravailabilityprimarilyfosteredthegrowthofpredominanttrees,whereasdroughtfavouredthegrowthofsmalltreesattheexpenseofthepredominantones.Wecouldnotdetectsignificantdifferencesbetweenmixedandmonospecificstandsinthisregard.Conclusions:Thedrought-inducedreallocationofgrowthinfavourofsmalltreesincaseofsprucemayresultfromitsisohydriccharacter.Wehypothesizethatassmalltreesareshaded,theycanbenefitfromthereducedwaterconsumptionoftheirsun-exposedtallerneighbours.Incaseofbeech,asananisohydricspecies,talltreessufferlessandsmallertreesbenefitlessunderdrought.Thediscussionelaboratestheconsequencesofthewaterdependentgrowthallocationforforestmonitoring,growthmodelling,andsilviculture.

简介：Objective:Smallcelllungcarcinoma(SCLC)isconsideredoneofthemostaggressivetypesoflungcancerduetoitsrapidgrowthandearlymetastasis.NotumormarkersortherapeutictargetshavebeendemonstratedtobespecificoreffectiveinSCLCtodate.ThisstudyaimstoevaluatethepotentialofFlotillin1(Flot1)asatargetofSCLCtreatment.Methods:Flot1expressionlevelinthetissueofSCLCandothertissueoflungdiseasewasdetectedusingimmunohistochemicalstaining.TranswellandMatrigelassayswereemployedtoexaminemigrationandinvasionofcancercells.FlowcytometryandxCELLigencesystemwereusedtoevaluatecellapoptosisandcellviability,respectively.ExpressionlevelsofFlot1,epithelialmesenchymaltransition(EMT)markerE-cadherin,vimentin,cyclinD1,TGF-β-Smad2/3,andp-AKTwereexaminedusingWesternblot.Furthermore,xenografttumorinnudemicewasusedtoevaluatethegrowthandmetastasisofNCI-H446cellsinvivo.Results:OurresultsdemonstratedthatFlot1ishighlyexpressedinSCLCsamplesandthatitsexpressioncorrelatesstronglywithclinicalstage,distantmetastasis,andpoorsurvival.TheknockdownofFlot1decreasedthegrowth,migration,andinvasivenessofSCLCcellsandreversedEMTphenotypeinvitroandinvivo,whileenhancedFlot1expressionexhibitedtheoppositebehavior.GeneexpressionprofileanalysisdemonstratedthatFlot1-regulatedgenesfrequentlymappedtotheAKTandTGF-β-Smad2/3pathways.OurresultsfurtherrevealedthatFlot1affectedtheprogressionofSCLCviaregulationofEMTprogression.Conclusions:ThesefindingsindicatedanoncogenicroleofFlot1viapromotingEMTinSCLCandsuggesteditspotentialasatumormarkerandprognosticindicator.

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简介：把压成薄片的弹性体的轴承广泛地在中国为small-to-medium-span高速公路桥被使用了，在哪个水泥砍钥匙横着被设置禁止大girder排水量。为了评估，更精确地衔接地震回答，轴承的合适的分析模型并且砍钥匙应该被开发。基于一系列周期的装载实验和分析，把压成薄片的弹性体的轴承的清醒的分析模型并且砍钥匙，能考虑机械降级，被开发。机械降级的效果被在大量山峰地面加速(针网阵列)下面在横向的方向检验一座small-to-medium-span桥的地震反应调查。为small-to-medium-span高速公路桥的损坏机制被决定，它能在最近的年里在地震期间解释地震损坏调查。把压成薄片的弹性体的轴承的机械性质将由于磨擦降级滑动的试验性的结果表演，而是减少的度依赖于影响参数。这能被结束把压成薄片的弹性体的轴承的机械降级并且砍钥匙在桥的地震反应起一个重要作用。把压成薄片的弹性体的轴承的机械性质的降级并且砍钥匙应该被包括评估更精确的桥牌地震性能。

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简介：Objective:Survivalbenefitofadjuvantchemotherapy(AC)ofpatientswithintrapulmonarylymphnode(IPLN)metastasis(level12-14)needsinvestigation.WeevaluatedtheimpactofAConpatientswhosemetastaticnodeswerelimitedtointrapulmonarylevelsaftersystematicdissectionofN1nodes.Methods:First,155consectivecasesoflungcancerconfirmedaspathologicN1werecollectedandevaluated.PatientsreceivedsystematicdissectionofN2andN1nodes.ForpatientswithIPLNmetastasis,survivaloutcomeswerecomparedbetweenthosereceivingACandthosenotreceivingAC.Results:Inthisgroup,112cases(72.3%)hadIPLNmetastasisand55cases(35.5%)hadN1involvementlimitedtolevel13-14withoutfurtherdiseasespreadtohigherlevels.PatientswithIPLNinvolvementhadabetterprognosisthanthatofpatientswithhilar-interlobarinvolvement.FortheintrapulmonaryN1group(level12-14-positive,level10-11-negativeorunknown,n=112),nosurvivalbenefitwasfoundbetweentheACgroupandnonACgroup[5-yearoverallsurvival(OS):54.6±1.6vs.50.4±2.4months,P=0.177].However,76of112casesforwhomharvestingoflevel-10andlevel-11nodeswasdonedidnotshowcancerinvolvementinpathologyreports(level12-14-positive,level10-11bothnegative),oncologicoutcomewasbetterforpatientsreceivingACthanthosenotreceivingACinthissubgroup(5-yearOS:57.3±1.5vs.47.1±3.2months,P=0.002).Conclusions:OncologicoutcomemaybeimprovedbyACforpatientswithinvolvementofN1nodeslimitedtointrapulmonarylevelsaftercompleteexaminationofN1nodes.