简介：基于在在定义变量和常数利用的数据的可靠性和代表性之间的关系，众多的费时间的方程要求复杂参数估计水流带来的碎石运输。包括流动分泌物，水深度，水表面斜坡，和表面谷物直径在这学习容易可存取的数据(来自在马来西亚的小河的d50)被用来估计水流带来的碎石运输。基因编程(GP)和人工的神经网络(ANN)当模特儿当估计床的互补工具在小河里基于在简洁和精确性之间的平衡装载运输，被使用。发达模型为ANN和GP与97%和93%的全面精确性表明高效，分别地与另外的传统的方法和实验方程相比。

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简介：Primarymalignanttumorsofthesmallintestinearerare,comprisinglessthan2%ofallgastrointestinaltumors.An85-year-oldwomanwasadmittedwithfeverof40℃andmarkedabdominaldistension.Hermedicalhistorywasunremarkable,butbloodexaminationshowedelevatedinflammatorymarkers.Abdominalcomputedtomographyshowedagianttumorwithcentralnecrosis,extendingfromtheepigastriumtothepelviccavity.Giantgastrointestinalstromaltumorofthesmallintestinecommunicatingwiththegastrointestinaltractorwithsuperimposedinfectionwassuspected.Becausenoimprovementoccurredinresponsetoantibiotics,surgerywasperformed.Laparotomyrevealedgianthemorrhagictumoradherenttothesmallintestineandoccupyingtheperitonealcavity.Thegianttumorwasasolidtumorweighing3490g,measuring24cm×17.5cm×18cmandshowingmarkednecrosis.Histologically,thetumorcomprisedspindle-shapedcellswithanaplasticlargenuclei.Immunohistochemicalstudiesshowedtumorcellspositiveforvimentin,CD31,andfactorⅧ-relatedantigen,butnegativeforc-kitandCD34.Angiosarcomawasdiagnosed.Althoughnopostoperativecomplicationsoccurred,thepatientexperiencedenlargementofmultiplemetastatictumorsintheabdominalcavityanddied42dpostoperatively.Theprognosisofsmallintestinalangiosarcomaisverypoor,evenaftervolume-reducingpalliativesurgery.

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简介：由于连接增加，小世界现象在基于树的无线传感器网络存在。基于树的网络的小世界上的流行病被学习，并且流行病的爆发在发生的流行阀值是计算的。当感染概率比过滤阀值大时，流行病学的过程被分析。尽管不同流行病学的过程发生在内在的树拓扑学上，当感染传播，感染的节点的数字指数地增加。一致免疫过程在同类的小世界的网络被进行。尽管免疫有效地减少流行速度，感染仍然指数地延长。

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简介：Tworecentstudieshavediscoveredasurprisinglinkbetweenthreeseeminglydifferentclinicaldiseases:onethatdestroysbonemarrow,anotherthatpreventssundamagefrombeingrepaired,andathirdwhichcauseschildrentoshowsignsofagingextremelyearly.Ithasbeenfoundthatallthreediseasesarecausedbymutationsinthesamegene.Mutationscomeinanumberofdifferentflavors,

简介：Thispaperproposesaconstitutivelawandamethodforcharacterizinghighlypreloadedviscoelasticmaterialssubjectedtolinear(small-amplitude)vibrations.Amultiplicativenon-separablevariableslawhasbeensuggestedtomodelthebehaviorthatdependsonbothstretchandtime/frequency.Thisapproachallowssplittingtheintricatecombinedtestperformedsimultaneouslyonbothstretchandfrequency,generallyinalimitedexperimentaldomainupto100Hz,intotwoindependenttests.Thus,ononehand,thedynamiccomplexmodulusdependentonfrequencyaloneisevaluatedonthebasisofvibrationtestsinalargeexperimentaldomainupto100kHz.Ontheotherhand,energeticparametersaredeterminedfromaquasi-statichyperelastictensiletest.Thecomplexmodulus,dependentonbothstretchandfrequency,isthendeducedfromtheresultsacquiredfromuncoupledinvestigations.Thisworkshowsthat,inextension,theelasticmodulusincreaseswithincreasingstretch,andthelossfactordecreaseswithincreasingstretch;while,incompression,aroundthematerialundeformedstate,themodulusincreasesasthestretchincreasestillacertainvalueofcompressionstretch(upturnpointdependingonmaterialcharacteristics),andthenthemodulusdecreasesasthestretchincreases.Globally,preloadrigidifiesmaterialsbutreducestheirdampingproperty.Theseresultscloselymatchawell-knownobservationinsolidmechanics.

简介：SmallRNAhasrecentlydrawnmoreandmoreattention.Inthispaper,weconcentrateontheinfluenceofnoisesongenenetworkregulatedbysmallRNAusingchemicalLangevinequation.Itshowsthatthenoisecancauseoscillationwhentheoscillatedoesnotoccurinthecorrespondingdeterministicsystem.Thecoherenceofthenoiseinducedoscillationreachesamaximumforanoptimalintensityofnoise,andthecoherenceresonanceappearsaccordingly.Thefindingsimplyprobablyomnipresentimportanceofnoiseinthefunctioningprocessoflivingorganism.

简介：Becauseoftheradioactivityandtoxicnatureofnuclearmaterials,theircontainmentwithinoxidematrices,encasedinsealedcontainers,hasbeenproposedasasuitablemeansforstorageandtransportation.However,containerfailuresbecauseofcracksorsmallorificespresentamajorleakageriskfornuclearmaterials,consequentlyposingasignificanthazardtotheenvironmentandhumanbeings.Inthisstudy,terbiumoxidepowderwasusedasanuclearmaterialrepresentativetoexaminetheleakageofnuclearmaterialpowderthroughorificeslocatedatthebaseofapressurecontainer.Thedependenceoftheorificediameter,thepowderlayerthickness,andtheinternalpressureofthecontainerontheleakagemechanismandamountwasexamined.Asimplifiedmodelcorrelatingthedependenceoftheabove-mentionedparameterstodeterminetheutmostleakageamountwasalsodevelopedbasedonthepresentresults.Theleakageofthenuclearmaterialpowderwasassessedbymeasuringitsconcentrationusinganopticalparticlecounter.Thediameteroftheorificedeterminedthepowderleakagemechanism,whichinturninfluencedtheamountofleakageproduced.Comparisonstudiesshowedthatunlikethechangesinthedifferentialpressure,thevolumeofthecontainerhaslittleeffectontheleakageamount.Undersufficientlyhighinternalpressures,theoxidepowdercanbereleasedasafineaerosol.Theworkisnotonlycrucialfromthenuclearsafetyaspect,butisalsobeneficialforthesafeapplicationofpowderandnanoparticles.

简介：ThefollowingcoupledSchrdingersystemwithasmallperturbationuxx+u-u3+βuv2+f(,u,ux,v,vx)=0inR,vxx-v+v3+βu2v+g(,u,ux,v,vx)=0inRisconsidered,whereβandaresmallparameters.ThewholesystemhasaperiodicsolutionwiththeaidofaFourierseriesexpansiontechnique,anditsdominantsystemhasaheteroclinicsolution.Thenadjustingsomeappropriateconstantsandapplyingthefixedpointtheoremandtheperturbationmethodyieldthatthisheteroclinicsolutiondeformstoaheteroclinicsolutionexponentiallyapproachingtheobtainedperiodicsolution(calledthegeneralizedheteroclinicsolutionthereafter).

简介：在脾缺乏老鼠的空肠纸巾在肠的推进率，浆液D木糖的内容，腺苷triphosphate(ATP)的内容和腺苷triphosphatases(ATPase)的活动上观察艾灸的效果的目的，并且在ATP的生产和膜蛋白质的活动上探索艾灸的效果，为在增强脾胃分析艾灸的机制。四十只健康SpragueDawley老鼠随机被划分成四个组，也就是组织A(空白的控制组)，组织B(模型控制组)，组织C(艾灸组)并且组织D(植物组)的方法。脾缺乏的动物模型被intragastric管理与黄达(根值et根茎Rhei)一起建立注入。在组C的老鼠收到了艾灸在Zusanli(圣36)，Zhongwan(CV12)，Guanyuan(CV4)，Pishu(BL20)和Weishu(BL21)。在组D的老鼠与Si6月Zi煎收到了intragastric管理。肠的推进被墨粉方法测量，并且在浆液的D木糖的内容被phloroglucinol方法检测。比色法方法被用来在空肠纸巾检测ATP的内容和Na+-K+-ATPase和Ca2+-Mg2+-ATPase的活动。与组A相比结果，肠的推进率，在浆液的D木糖的内容，ATP的内容，在空肠纸巾的Na+-K+-ATPase和Ca2+-Mg2+-ATP的活动在组B显著地减少了(P<0.05或P<0.01)。与组B相比，肠的推进率，在浆液的D木糖的内容，ATP的内容，在空肠纸巾的Na+-K+-ATPase和Ca2+-Mg2+-ATPase的活动在组C和D显著地增加了(P<0.05或P<0.01)，当组C和组D之间没有重要差别时。结论艾灸能增加肠的推进率，在浆液的D木糖和在空肠纸巾的ATP的内容，以及Na+-K+-ATPase的活动和脾缺乏老鼠的Ca2+-Mg2+-ATPase，它建议那艾灸能由在肠的上皮的房间支持ATP的生产提高小肠的活动性和吸收功能，增加膜蛋白质的内容，并且改进transmembrane运输。

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简介：倾斜地，事件水波浪在二层的液体由在小底部波动形式的一张不平的隧道床散布在三维的线性水波浪理论的框架工作以内被调查。上面的液体被假定被一个僵硬的盖上面跳，当更低的被有小变丑的底部表面下面围住，隧道在水平方向是无界的时。假定无旋的运动，不安技术被采用计算一阶的修正到在由使用Fourier的二液体的潜力近似，并且也转变以包含代表底部变丑的形状功能的积分计算思考和传播系数的速度。正弦曲线涟漪的一个补丁的考虑证明思考系数是比率的摆动的功能两次沿着X轴和涟漪波浪的波浪数字的部件数字。当这比率接近一个时，理论预言在床和接口之间的一个反响的相互作用，并且思考系数变得一涟漪的数字多重。如果这个数字大，事件波浪精力的高思考发生。

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简介：Objective:Toassessifdiffusion-weightedmagneticresonance(MR)imagingwithoutapparentdiffusioncoefficient(ADC)valuesprovidesaddeddiagnosticvalueincombinationwithconventionalMRimaginginthedetectionandcharacterizationofsmallnodulesincirrhoticliver.Methods:Twoobserversretrospectivelyandindependentlyanalyzed86nodules(≤3cm)certifiedpathologicallyin33patientswithlivercirrhosis,including48hepatocellularcarcinoma(HCC)nodules,13high-gradedysplasticnodules(HDN),10low-gradedysplasticnodules(LDNs)and15otherbenignnodules.AllthesefocalnoduleswereevaluatedwithconventionalMRimages(T1-weighted,T2-weightedanddynamicgadolinium-enhancedimages)andbreath-holddiffusion-weightedimages(DWI)(b=500s/mm2).Thenoduleswereclassifiedbyusingascaleof1-3(1,notseen;3,wellseen)onDWIforqualitativeassessment.Thesesmallnoduleswerecharacterizedbytworadiologists.ADCvaluesweren’tmeasured.ThediagnosticperformanceofthecombinedDWI-conventionalimagesandtheconventionalimagesalonewasevaluatedusingreceiveroperatingcharacteristic(ROC)curves.Theareaunderthecurves(Az),sensitivityandspecificityvaluesforcharacterizingdifferentsmallnoduleswerealsocalculated.Results:Among48HCCnodules,33(68.8%)weregradedas3(wellseen),6(12.5%)weregradedas2(partiallyobscured),and9weren’tseenonDWI.Among13HDNs,therewere3(23.1%)and4(30.8%)gradedas3and2respectively.Five(50%)of10benignnoduleswerepartiallyobscuredandslightlyhyperintense.For86nodules,theaveragediagnosticaccuracyofcombinedDWI-conventionalimageswas82.56%,whichwasincreasedsignificantlycomparedwithconventionalMRimageswith76.17%.ForHCCandHDN,thediagnosticaccuracyofcombinedDWI-conventionalimagesincreasedfrom78.69%to86.07%.Conclusions:Diffusion-weightedMRimagingdoesprovideaddeddiagnosticvalueinthedetectionandcharacterizationofHDNandHCC,anditmaynotbehelpfulforLDNandregenerativenodule(RN)incirrhot

简介：Purpose:Anumberofdifferentclinicalcharacteristicshavebeenreportedtosinglycorrelatewiththerapeuticactivityofepidermalgrowthfactorreceptor(EGFR)tyrosinekinaseinhibitors(TKIs)inadvancednon-small-celllungcancer(NSCLC).Thisstudyaimedtoidentifypredictivefactorsassociatedwithprognosticbenefitsofgefitinib.Patientsandmethods:EGFRgenetypingin33advancedNSCLCpatientsreceivedgefitinib(250mg/day)wereanalyzedwithmutant-enrichedPCRassay.Gefitinibresponsewasevaluatedwithpotentialpredictivefactorsretrospectively.Results:Theoverallobjectiveresponserate(ORR)andmedianprogression-freesurvival(PFS)inthe33patientstreatedbygefitinibwere45.5%and3.0(2.0-4.0)months.TheORRandmedianPFSinEGFRgenemutationpatientsweresignificantlyhigher/longerthanthoseinEGFRgenewild-typepatients(P<0.01).Similarly,theORRandmedianPFSinnon-smokerpatientsweresignificantlyhigher/longerthanthoseinsmokerpatients(P<0.05,P<0.01,respectively).However,nodifferenceforORRandmedianPFSoccurredbetweenmaleandfemalepatients.LogisticmultivariateanalysisshowedthatonlyEGFRmutatedgenewassignificantlyassociatedwiththeORR(P<0.01).BothEGFRmutatedgeneandnon-smokerwerethemajorfactorsthatcontributedtoPFS(P<0.05).Conclusions:EGFRmutatedgeneandnon-smokerstatusarepotentialpredictorsforgefitinibresponseinNSCLCpatients.

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