简介：AbstractObjective:Few reports have described intracranial hemangiomas and structural brain and/or arterial anomalies in patients with infantile hemangiomas. This study was performed to examine the magnetic resonance imaging findings of intracranial abnormalities in a group of infants with hemangiomas in the head and neck regions.Methods:We reviewed our hemangioma treatment center database from January 2010 to July 2018 to assess the prevalence of intracranial abnormalities in infants with hemangiomas in the head and neck regions. Clinical and electronic magnetic resonance imaging data were also retrieved from the patients’ medical charts.Results:Of 436 patients with infantile hemangiomas in the head and neck regions, 23 (5%) had intracranial abnormalities, including 20 (23%) with segmental hemangiomas and 3 (1 %) with focal hemangiomas. In total, 14 patients had intracranial hemangiomas located within the ventricle and cisterns or ipsilateral lesions involving the extradural space. Eight patients had intracranial structural abnormalities, such as cerebellar dysplasia, Dandy-Walker malformation, and hydrocephalus. Five patients had intracranial arterial anomalies, and three patients had arteriovenous malformations.Conclusions:These findings support the hypothesis that intracranial hemangiomas are commonly associated with segmental infantile hemangiomas in the head and neck regions.

简介：Facialnervehemangiomasarerarebenignvasculartumorswithprimarysymptomsincludingprogressivefacialnervepalsyandhearingloss.Theycaninvolvevarioussegmentsofthefacialnerve,especiallythegeniculateganglion(G.G.).PreoperativeMRIandCTimaginingisofgreatimportanceforearlydiagnosisofsuchlesions.Themostacceptedtreatmentforfacialnervehemangiomasissurgicalexcision1andthetypeofapproachdependsontumorlocation,preoperativehearinglevelandtumorsize.Inconsiderationofthedifficultiesindifferentialdiagnosis,otologistsshouldpayattentiontoavoidmissedorincorrectdiagnosisinhemangiomasoffacialnerve.

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简介：Location:Thelinefromthemiddlepointofeyebrowsuptotheanteriorhairline.Manipulation:Thechildliesonhisbackandthepractitionerstandsinfrontofthechild'shead.Fixtheheadwithtwohands,andkneadfromthemiddlepointofeyebrowsuptotheanteriorhairlinewithalternatebellyofhands(Fie.1）.

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简介：Inthisarticle,effectivefingerpressuremethodsforthetreatmentofinfantileindi-gestionwereintroduced,whichincludebackfingerknockingmethod,Jiajipointspressingmethodandabdomenfingerpressingmethod.64caseshavebeenobserved.Amongthem,cured:43cases,significantlyimproved:12cases.Thetotaleffectiverate:98.4%.Theresultsshowedthatfingerpressuremethodisaneffectiveexternaltreatmentmethodwhichhasthecharacteristicsofsimplicity,nodamage.Thismethodcanbewidelyacceptedbychildren.

简介：Inthepresentpaper,thetherapeuticeffectofacupunctureof"Shesanzhen"(threeacupointsofthetongue)combindwithacupoint-injectionandoraladministrationofChinesepatentdrug["ZhenRenYizhiBao"(真人益智宝)]inthetreatmentof284casesofinfantileaphasiswasopserved.Afteronecourseoftreatment(4months),93cases(32.75%)werecured,76(26.76%)experiencedmarkedimprovement,102(35.92%)hadimprovement,withaneffectiverateof95.43%.

简介：目的：观察推拿结合药物治疗婴幼儿轮状病毒感染性腹泻的临床疗效。方法：将确认的55例患儿按就诊先后随机分为2组。药物组30例，采用静脉滴注利巴韦林、口服思密达治疗；推拿加药物组25例，进行补脾经、清大肠、顺时针摩腹揉脐、推上七节骨、揉龟尾、捏脊等推拿手法治疗。并配合与药物组相同的药物治疗。结果：推拿加药物组总有效率96％，与药物组相比，P〈0．01。结论：推拿对治疗轮状病毒感染的婴幼儿腹泻具有良好的治疗效果，对于缩短病程、提高疗效、降低医疗费具有重要意义。

简介：在对待婴儿的肌肉发达的torticollis加超声的治疗观察tuina的临床的功效。

简介：以推、揉、拿、扳、拉等手法，治疗22例肌性斜颈患儿，治愈18例，显效3例，无效1例。总有效率95．4％。

简介：SinceJanuaryof1997,theauthorofthepresentpaperhasadoptedacupuncturetherapytotreatchildcoughandachievedabettertherapeuticeffect.Hereisthesummary.

简介：Objective:Toinvestigateifhyperbaricoxygen(HBO)mayinducestructuralchangesofneuronsinhippocampusfrominfactileratsandifthechangesarereversible.Methods:All27healthySDinfantileratswereexposedtoHBO(0.25MPa)orhyperbaricair(HBA)for1to3courses(10daysas1course).Thehippocampuswastakenattheendofeachcoursetoobserveitsmorphologybylightmicroscopeandelectronmicroscope.Results:HBOexposureinducedcapillarydilation,nuclearmembranewindingorblurringandsomemitochondriaswellingwithitscristablurringinneurons.Thechangesoccurredafter1courseexposureandbecamesignificantwithtime.Mostofthechangesrecovered20daysafterstoppingexposure.NochangewasfoundafterHBAexposure.Conclusions:Long-termHBOexposurecancausecapillarydilationandultrastructuralinjuryofneuronsinhippocampusfrominfantilerats.Thedamageisnotserious,butreversible.

简介：AbstractImportance:Infantile convulsions and choreoathetosis (ICCA) is a rare neurological disorder. Many affected patients are either misdiagnosed or prescribed multiple antiepileptic drugs.Objective:To explore therapeutic drug treatments and dosages for ICCA in children.Methods:Detailed clinical features (e.g., past medical history and family history), genetic features, and treatment outcomes were collected from the records of six patients with ICCA.Results:Mean age at paroxysmal kinesigenic dyskinesia (PKD) onset was 8 years 8 months (range, 3-12 years); the clinical presentation was characterized by daily short paroxysmal episodes of dystonia/dyskinesia. All patients had infantile convulsions at less than 1 year of age, and the mean onset age was 5.5 months (range, 4-7 months). Two patients had a family history of ICCA, PKD, or benign familial infantile epilepsy. Whole exome sequencing identified the c.649-650insC mutation in PRRT2 in six patients; three mutations were inherited and three were de novo. All patients were prescribed low-dose carbamazepine and showed dramatic improvement with the complete disappearance of dyskinetic episodes after 3 days. They attended follow-up for 5-17 months and were attack-free until the final follow-up.Interpretation:PRRT2 mutations are the primary cause of ICCA. Low-dose carbamazepine monotherapy is effective and well-tolerated in children.

简介：Toinvestigatethematernal-infantileinfectionwithhumanparvovirusB19,theIgGandIgMantibodiesagainsthumanparvovirusandtheB19-DNAinserumandperipheralbloodmononuclearcells(PBMC)ofpregnantwomenaswellastheserumIgMantibodyagainstB19andtheB19-DNAinserumandcordbloodnucleatedcells(CBNC)ofnewbornsweredeterminedbyELISAandnestedPCRrespectively.ItwasfoundthatthepositiverateoftheIgGantibodyagainsthumanparvovirusB19inseraof92pregnantwomenwas38.04%(35/92),andthatoftheIgMantibodyin720pregnantwomenwas9.03%(65/720).However,theIgMantibodyagainsthumanparvovirasB19wasnegativeinthecordbloodseraof95newborns.AstothehumanparvovirasB19DNA,noneof720pregnantwomenand95newbornswasprovedtobepositiveintheirsera,Nevertheless,thepositiverateoftheparvovirasB19DNAinPBMCwas3.06%(3/98)in98pregnantwomenand1.12%(1/89)inCBNCof89newborns.ItisconcludedthatthehistoryofinfectionwithhumanparvovirasB19existsincertainpregnantwomenwithasmallpercentageofpregnantwomeninfectedwithrecentoracuteinfectionsofB19virus.ThedetectionratesoftheB19viralDNAinPBMCofpregnantwomenandCBNCofnewbornswerehigherthanthoseinsera,indicatingthattheriskforverticaltransmissionisverylow.

简介：Thispaperreportedthat2785in-patientswithinfantilediarrheaweretreatedwithmoxaconemainlyonpointsHegu(LI4),Zhongwan(CV12),Shenque(CV8),Zusanli(ST36)andPishu(EL20).Asaresult,2520cases(90.5%)weretreatedwithexcellenttherapeuticef-fectiveness;233(8.4%),good,and32(1.1%),poor.Thetotaleffectiveratereached98.9%.

简介：Objective:SHR-1210isanewandpromisinganti-PD-1agentforsolidtumors.DuringthephaseIstudyofSHR-1210,weencounteredanovelbutprevalentimmune-relateddermatologictoxicity:reactivecapillaryhemangiomas(RCHs).ThuswetriedtosummarizethefeaturesofRCHsandestimatetheirrelationshipwithtumorresponse.Methods:Thisprospectiveobservationalstudysystematicallyenrolled98patientswithadvancedsolidtumorsfromApril27th,2016toJune8th,2017inthecontextofthephaseIclinicalstudyofSHR-1210.Thisreportfocusedontheskintoxicities.Patientsunderwententireskininspectioneverytwoweekswhiletakingmedication.TheclinicalcourseofRCHswasrecordedandtheirassociationwithtumorresponsewasestimated.Thedatacut-offdatewasNovember15th,2017.Results:Afteramedianfollow-upof242(range,29–567)days,RCHswereobservedin85.7%(84/98)ofpatientsoncutaneous/mucosalsurfaces;84.5%(71/84)oftheRCHswereevaluatedasgrade1adverseevents.Nograde3or4RCHswereobserved.ThetimeofonsetofRCHswasdosedependentandshortestinthe400mg-dosecohort(P<0.001).SpontaneousandcompleteregressionofRCHswasobservedbothduringandaftertreatment.TheobjectiveresponserateoftumorsforpatientswithRCHswas28.9%(24/83).However,noresponderswereobservedamongthepatientswithoutRCHs.Conclusions:RCHswereprevalentbutmanageableduringtreatmentwithSHR-1210.Itmightaddtotheexpandingliteratureregardingimmune-relateddermatologicadverseevents.

简介：目的：观察采用具有通经活络作用的推拿、针刺、穴位注射三种方法综合治疗小儿臂丛神经损伤的临床效果。方法：用一指禅推法、拿法、揉法等手法放松患侧颈项及上肢部，点按颈夹脊、肩井、扶突、极泉、肩髑、曲池等穴位；针刺采用毫针刺颈夹脊、天窗、扶突、极泉、曲池、外关、阳池、合谷等主穴及相应的配穴，平补平泻；穴位注射用曲力甲钴胺注射液，选取肩髑、肩髂、曲池、手三里、外关、阳池、合谷等分别注射，隔日一次。结果：35例患儿中，痊愈22例，显效9例，好转4例。结论：”通络三法”治疗小儿臂丛神经损伤具有临床效果好，疗程短的优点。

简介：AbstractImportance:Cancer is the main cause of death by disease in children. Children experience the highest incidence of cancer in the first year of life. However, there is no comprehensive registration system for children with tumors in China.Objective:To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized diagnosis and management among several treatment centers in Beijing, China, thereby providing evidence to guide further clinical research.Methods:From January 1, 2010 to December 31, 2019, patients with newly diagnosed infantile malignant solid tumors were admitted to six large tertiary pediatric solid tumor diagnosis and treatment centers in Beijing. The epidemiology, clinical features, and therapeutic effects of tumors in these patients were analyzed retrospectively. All patients were followed up until March 31, 2020.Results:In total, 938 patients were enrolled in this study. There were 530 boys (56.5%) and 408 girls (43.5%); the median age was 6.0 months (range, 0-12.0 months). The three most common tumors were retinoblastoma in 366 patients (39.0%), neuroblastoma in 266 patients (28.4%), hepatoblastoma in 133 patients (14.2%), and central nervous system tumors in 52 patients (5.5%). The estimated 5-year overall survival rate was 81.3% ± 1.8%, and the 5-year event-free survival rate was 71.8% ± 2.9%. The 5-year overall survival rates of non-rhabdomyosarcoma soft tissue sarcoma, neuroblastoma, and retinoblastoma were 100%, 88% ± 2.2%, and 86.9% ±2.1%, respectively. The 5-year event-free survival rates were 81.1% ± 2.7% for neuroblastoma, 81.6% ± 9.8% for non-rhabdomyosarcoma soft tissue sarcoma, and 72.7% ± 14.1% for extracranial malignant germ cell tumors.Interpretation:The three most common infantile malignant solid tumors were retinoblastoma, neuroblastoma, and hepatoblastoma. Multidisciplinary combined diagnosis and treatment is needed for infantile tumors.