简介:<正>Recentlyrefurbishied,NovotelBeijingisawell-establishedbusinesshotel,nowcomple-mentedbyActor’srenownedinternationalstan-dardsofqualityandservice.All344well-ap-pointedroomsandsuitesfeaturethelatestin-roomtechnology.Alimousineservice,conciergeandKoreantosatisfytheguests.ThenewlyopenedLeCabernet,locatedattheentranceofNovotelPeaceBeijing,isaFrenchstylewinebarandbistro.Ithasawarmambiencewithsoftmusicandreasonableprices.
简介:EInk'smicrocapsulesarefilledwithaclearliquidthatholdsverysmallparticles.Someparticlesareblack.Somearewhite.Alloftheparticleshaveane-lectricalcharge.Tomakeasheetofelectronicpaper,engineersspreadmillionsoftheparticle-filledmicro-capsulesontoapieceofplastic.
简介:Sincethebeginningofthe21stcentury,andinparticularafterthe2008worldfinancialcrisis,relationsbetweenthegreatpowershavebeenundergoingaprofoundtransformation,andinternationalpatternshavechangedsignificantly.AlthoughnotasdramaticandunexpectedasthedisintegrationoftheformerSovietUnionandtheendoftheColdWar,thisdirefinancialcrisisforebodesanirreversibletrendofmultipolarizationintheworld,andexertsadeepinfluenceonworldpatterns.Thestrawinthewindisthechangesinrelationsbetweenthegreatpowers.
简介:AbstractTransparency Ecosystem for Research and Journals in Medicine (TERM) working group summarized the essential recommendations that should be considered to review and publish a high-quality guideline. These recommendations from editors and reviewers included 10 components of essential requirements: systematic review of existing relevant guidelines, guideline registration, guideline protocol, stakeholders, conflicts of interest, clinical questions, systematic reviews, recommendation consensus, guideline reporting and external review. TERM working group abbreviates them as PAGE (essential requirements for Publishing clinical prActice GuidelinEs), and recommends guideline authors, editors, and peer reviewers to use them for high-quality guidelines.
简介:深深地理解网站复杂性,一个网页复杂性测量系统被开发。系统在二个层次测量一网页的复杂性:运输级并且内容水平,用一个包,基于踪迹的途径而非服务者或顾客记载。包踪迹在包含的信息的数量超过其它。量的分析证明网页的不同范畴有不同复杂性特征。试验性的结果证明一新闻网页通常在更多并发的传播控制协议(TCP)上在多样的行政领域以内从更多网服务者在更多的存取层次装载更多元素流动。关于多于教育的一半分页各个,仅仅包含一些逻辑服务者,大多数一张网的元素在哪儿分页,仅仅从一或二个逻辑服务者被取。为在登录以后的网比赛交通的内容类型的数字通常是最少的。系统能帮助网页设计者设计更有效的网页,并且帮助研究人员或因特网用户知道通讯细节。
简介:摘要遗传性视网膜变性(IRD)发病机制复杂多样,常常导致不可逆盲,目前尚缺乏有效的治疗方法。近年来,针对IRD的基因治疗显示出广阔的应用前景,而如何将基因药物递送至靶细胞并安全、高效地表达成为目前研究发展的关键点。病毒载体系统转染效率较高,但具有潜在的免疫反应和生物安全等问题,其临床应用的局限性使非病毒载体系统的开发应运而生。DNA纳米复合体是新型非病毒载体的研究热点之一,这种聚合物/DNA复合物纳米粒子由多肽、脂质、多糖等物质压缩和包裹DNA而成,在IRD的应用上取得了较大的进展。此外,非病毒载体在成本、制备难易度、包装容量及安全性上均显示出其优势,为视网膜色素变性、Stargardt病、先天性视网膜劈裂、Leber先天性黑矇等IRD的基因治疗提供了新的研究思路。本文对近年来非病毒载体系统在转染效率、靶向性和安全性等方面的进展及其在IRD基因治疗中的应用进行综述。