Accuracy Measurements of the CAS-LIBB Single-Particle Microbeam for Single Cell Irradiation

(整期优先)网络出版时间:2004-10-20
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Asingle-particlemicrobeamfacilityhasbeenconstructedattheLaboratoryofIonBeamBioengineering(LIBB),ChineseAcademyofSciences.Thesystemisdesignedtodeliverthedefinednumberofhydrogenions,coveringarangeofenergyfrom1.0to3.5MeV,intoanareasmallerthanthenucleiofinpiduallivingcells.AccuracyoftheparticledetectionsystemandthecelltargetingsysteminthefacilityhasbeenassessedusingCR39(nucleartrackdetector)for2.3MeVprotons.Theresultsdemonstratethattheparticledetectionefficiencyisabove98%,andtheoveralltargetingaccuracyofthemicrobeamislimitedwithin3μmformorethan90%hits.