AIM:Toestimatethepotentialsystemiceventsduringandafterretinopathyofprematurity（ROP）screening.METHODS:Aprospectiveanddescriptivedesignedstudywasconductedtodetectthephysiologicandpathologicalchanges24hbefore,during,and72hafterROPscreening.Controlbloodpressure（BP）,saturation,pulserate,andbodytemperaturewereroutinelytakenatvarioustimeinternalsbeforeandafterscreening.Adverseeffectspertaintocardiovascularsystem,respiratorysystem,gastricsystem,urinarysystemandnervoussystemwereretrospect0-72hafterROPscreeningata24-hourinterval.RESULTS:Totally1254prematuritybabiesreceivingROPscreeningduringJan.1st2013toDec.31th2013wereenrolledinoursurvey.Comparedtocontrolvitalsigndatatakenbeforetheexamination,therewasafluctuationinthediastolicBPwiththeincreased3.03mmHg（P=0.04）after3dosesofmydriaticdrops.Immediatelyaftertheexamination,therewasafurther12.64mmHg（P<0.01）increaseinsystolicBPanda7.24mmHg（P<0.01）indiastolicBP.Themeanpulserateduringexaminationwas22.4bpm（P<0.01）higherthanthe133.3±9.0bpmcontrollevel.Theoxygensaturationsharedanaveragedropof5%（P<0.01）duringscreening.Inprematuritywithpostconceptionalagelessthan31wk,theincidenceofapnea（23.5%）,necrotizingenterocolitis（NEC）（8.7%）,gastricresidual（25.4%）andupperdigestivetracthemorrhage（6.4%）alsodemonstratedasignificantrise（P<0.01）.CONCLUSION:Inourstudysample,ROPscreeningwasassociatedwithNEC,gastricresidualandupperdigestivetracthemorrhage.Thesegastrointestinalsideeffects,alongwithbreathactivitypatternchangeandvitalsignsindicatorsfluctuation,mayberesultsofadditionalstressresponses.
