SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo

PolysaccharidecoatedPLAnanoparticlesbearingaldehydegroupswerepreparedbydialysisofDMSOsolutionofcholesterolhydrophobic-modifieddextranpolyaldehydeandPLAagainstwater.Theaveragediameterofthenanoparticleswasabout160nm,andthesizedistributionwasnearlyhomogenous.ThenanoparticleswerefunctionalizedsimultaneouslywithCD71andEGFRantibodythroughtheSchiff'sbasereaction,andthenradiolabeledwith~(99m)Tc.Afterperfusedtheradiolabelednanoparticlesintotumor-bearing...