简介:基于FE,模拟被建议预言热短小裂缝和表面的出现的一个损坏预言方法在液体固体挤出过程裂开。这个方法综合批评温度标准和可锻的损坏模型,它被用来预言热短小裂缝和表面的开始分别地产品击碎的Cockcroft与Latham。有热转移以及可锻的损坏的变丑的Acoupling模拟被执行在Csf/AZ91Dcomposites的损坏行为上调查挤出温度和挤出速度的效果。半固体地区向变丑地区逐渐地移动,穿孔机下降,这被结束。在出口的温度上升的振幅从温度在给定的穿孔机排水量在不变的挤出期间随挤出速度的增加增加的起始的营舍死。以便在composites的早期的融化温度以外阻止产品的表面温度,批评挤出速度随挤出温度的增加被减少,不那样,热短小裂缝将发生。最大的损坏价值与增加挤出速度或挤出温度增加。理论结果由Deform获得了?-2D模拟与实验同意很好。
简介:Silicide涂层被泥浆包硬化进程为把SiO2用作纯艾尔Si来源的12h在1173K在铜矩阵上在electro-deposited镍层上作好准备作为reducer搽粉,NaF+NH4Cl和蛋白(鸡蛋白人)是连贯的代理人。微观结构,性质和silicide涂层的siliconizing机制被讨论。有220μm厚度的silicide涂层主要是的试验性的结果表演Ni2Si阶段和Ni31Si12阶段。它的吝啬的微坚硬(HV790)比铜底层(HV70)的是十次。磨擦的系数从0.8纯铜减少到大约0.3硅Z样品。SiF2,SiCl2和SiCl3在泥浆包装硬化过程期间为Si的交通和免职负责。
简介:AbstractObjective:Endoscopic repair of large anterior skull base (ASB) defects has excellent results when using multilayered repairs with a nasoseptal flap. However, in extensive intranasal tumors, a nasoseptal flap may not always be available. One alternative option is a flexible single-layer ASB repair. Initial studies indicate low cerebrospinal fluid leak rates with a single-layer repair. However, the level of frontal lobe support, particularly the propensity for a significant inferior displacement of the frontal lobe, is not known. The goal of this study is to determine the frontal lobe position after single-layer acellular dermal allograft repair in large ASB defects.Study Design:Retrospective cohort study.Setting:Tertiary care medical center.Subjects and Methods:This cohort study compares the frontal lobe position in adults who underwent endoscopic endonasal ASB tumor resection and single-layer cadaveric dermal matrix repair (ASB cohort) with control subjects without intracranial abnormalities (control cohort). The ASB cohort includes subjects with an ASB defect of ≥5 cm anterior/posterior and ≥1.5 cm wide and who had imaging at least 2 months after surgery. The frontal lobe position is measured on sagittal CT/MRI using a reference line from the base of the sella to the nasion. A value of zero indicates that the inferior-most aspect of the frontal lobe is at the level of the nasion-sellar line. A positive value indicates that the frontal lobe is inferior to the nasion-sellar line. The ASB cohort frontal lobe position is compared with the control cohort using the Mann-Whitney U test. A priori we set an absolute difference of 5 mm as a clinically significant difference.Results:The ASB cohort includes 47 subjects who are 57% male with an average age of 60 years (range: 31-89 years). The most common ASB pathology is esthesioneuroblastoma (n = 21) and 81% of the ASB cohort had postoperative radiation. The control cohort includes 20 subjects who are 60% male, with a mean age of 45 years (range: 19-74 years). The majority of controls underwent imaging for head trauma (n = 13). The ASB mean frontal lobe position is -0.2 mm superior to the nasion-sellar line (range: -9.2 to 10.4 mm), while the control's mean frontal lobe position is 1.1 mm inferior to the nasion-sellar line. This difference is not statistically significant (P= 0.13) and does not reach our a priori definition of clinical significance. The frontal lobe position of ASB subjects who had radiation is closer to the nasion-sellar line as compared with those who did not undergo radiation.Conclusions:Single-layer acellular dermal graft repair maintains frontal lobe support and position in large ASB defects.
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简介:Microstructuresandmechanicalpropertiesoftransientliquidphase(TLP)bondedmagnesiummetalmatrixcomposite(MMC)jointsusingcopperinterlayerhavebeeninvestigated.Withanincreaseofbondingtimesfrom5minto50minatbondingtemperatureof510℃,theaverageconcentrationofcopperinthebondedzonedecreased,themicrostructureinthezonechangedfromCu,α-MgandCuMg2toα-Mg,CuMg2andTiC,andmechanicalpropertiesofthejointincreased.Theshearstrengthofthejointbondedat510℃for50minreached64MPaduetothemetallurgicalbondingofthejointandimprovingitshomogeneityofcompositionandmicrostructure.ItisfavorabletoincreasethebondingtimeforimprovingmechanicalpropertiesofTLPbondedmagnesiumMMCjoint.
简介:AIM:Toconstructfunctionalhumanfull-thicknesscornealreplacements.METHODS:Acellularporcinecornealmatrix(APCM)wasdevelopedfromporcinecorneabydecellulariztion.Thebiomechanicalpropertiesofanterior-APCM(AAPCM)andposterior-APCM(PAPCM)werecheckedusinguniaxialtensiletesting.Humancornealcellswereobtainedbycellculture.Suspendingringwasdesignedbydeformationofanacupunctureneedle.MTTcytotoxicityassaywasusedtocheckthecytotoxicityofsuspendingringsoakingsolutions.Anewthree-dimensionalorganculturesystemwasestablishedbycombinationofsuspendingring,48-wellplateandmediumtogether.Ahumanfull-thicknesscornealsubstitutewasconstructedfromhumancornealcellswithAAPCMinanorgancoculturesystem.Biochemicalmarkerexpressionoftheconstructwasmeasuredbyimmunofluorescentstainingandmorphologicalstructureswereobservedusingscanningelectronmicroscopy.Pumpfunctionandbiophysicalpropertieswereexaminedbypenetratingkeratoplastyandfollow-upclinicalobservations.RESULTS:TherewerenocellsintheAAPCMorPAPCM,whereascollagenfibers,Bowman’smembrane,andDescemet’smembranewereretained.ThebiomechanicalpropertyofAAPCMwasbetterthanPAPCM.HumancornealcellsgrewbetterontheAAPCMthanonthePAPCM.Therewasnocytotoxicityforthesuspendingringsoakingsolutions.Fortheconstructedfull-depthhumancornealreplacementskeratocytesscattereduniformlythroughouttheAAPCMandexpressedvimentin.TheepitheliallayerwaslocatedonthesurfaceofBowman’smembraneandcomposedofthreeorfourlayersofepithelialcellsexpressingcytokeratin3.OnelayerofendothelialcellscoveredthestromalsurfaceofAAPCM,expressedNa+/K+ATPaseandformedtheendotheliallayer.Theconstructwassimilartonormalhumancorneas,withmanymicrovilliontheepithelialcellsurface,stromalcellswithalongshuttleshape,andzonulaoccludensontheinterfaceofendothelialcells.Theconstructwithstoodsurgicalprocedu
简介:BACKGROUND:Theintegrityofthebloodbrainbarrier(BBB)playsanimportantroleinthepatho-physiologicalprocessofcerebralischemia/reperfusioninjury.Ithasbeenrecentlyobservedthatmetalloproteinase-9(MMP-9)iscloselyrelatedtocerebralischemia/reperfusioninjuryOBJECTIVE:ThisstudywasdesignedtoobserveMMP-9expressionintheratbrainaftercerebralischemia/reperfusioninjuryandtoinvestigateitscorrelationtoBBBpermeability.DESIGN,TIMEANDSETTING:Thisstudy,arandomizedcontrolledanimalexperiment,wasperformedattheInstituteofNeurobiology,CentralSouthUniversitybetweenSeptember2005andMarch2006.MATERIALS:NinetyhealthymaleSDrats,aged3–4months,weighing200–280g,wereusedinthepresentstudy.Rabbitanti-ratMMP-9polyclonalantibody(Boster,Wuhan,China)andEvansblue(Sigma,USA)werealsoused.METHODS:Allratswererandomlydividedinto9groupswith10ratsineachgroup:normalcontrolgroup,sham-operatedgroup,andischemiafor2hoursfollowedbyreperfusionfor3,6,12hours,1,2,4and7daysgroups.Intheischemia/reperfusiongroups,ratsweresubjectedtoischemia/reperfusioninjurybysutureocclusionoftherightmiddlecerebralartery.Inthesham-operatedgroup,ratsweremerelysubjectedtovesseldissociation.Inthenormalcontrolgroup,ratswerenotmodeled.MAINOUTCOMEMEASURES:BBBpermeabilitywasassessedbydeterminingthelevelofeffusionofEvansblue.MMP-9expressionwasdetectedbyanimmunohistochemicalmethod.RESULTS:All90ratswereincludedinthefinalanalysis.BBBpermeabilityalterationwascloselycorrelatedtoischemia/reperfusiontime.BBBpermeabilitybegantoincreaseatischemia/reperfusionfor3hours,thenitgraduallyreachedapeaklevelatischemia/reperfusionfor1day,andthereafteritgraduallydecreased.MMP-9expressionbegantoincreaseatischemia/reperfusionfor3hours,thengraduallyreacheditspeaklevel2daysafterperfusion,andthereafteritgraduallydecreased.CONCLUSION:
简介:Thestatusandthevariationofelectricalresistanceofimpactedcarbonfiber/epoxy-matrixcompositeswerestudiedbyultrasonicF-scanandelectricalresistancemeasurementTheexperimentalresultsshowsthatimpactdamageenergythresholdvalueofcarbonfabric/epoxy-matrixcompositescandeterminebyusingultrasonicF-scan.Whentheimpactenergyexceedsthethresholdvalue,damageisgeneratedincomposites.Electricalresistanceofimpactedcompositesischangedowingtothecontactofeachcarbonfiberunitincomposites,whichcauseachangeoftheseries-parallelinconductors.Theveracityofdetectingimpactdamageincompositescanbeimprovedinthiscase.
简介:Inthepresentwork,anovelhybridcompositecomposedofTi-aluminidemulti-layeredpartandcontin-uous-SiCf-reinforcedTi-matrixpartusingavacuumhotpressing/hotisostaticpressure(VHP/HIP)sinteringprocesswassynthesized.Then,thedamagetolerancebehaviorofthishybridcompositewasstudiedbytensiletestsandinsituscanningelectronmicroscopy(SEM)three-pointbendingtests.Theresultsindicatethatthemechanicalpropertiesandcrackpropagationofthehybridcompositearestronglyinfluencedbytheextrinsictoughnessmecha-nism.Indetail,thecrackdeflectionofmulti-layeredcompositeandstrengtheningeffectofSiCf-reinforcedmatrixcompositeareobservedinthehybridcomposite.Owingtothestrengtheningeffectofcontinuous-SiCrre-inforcedTi-matrixpart,thetensilestrengthofhybridcompositeismuchhigherthanthatofneatTi-aluminidemulti-layeredcomposite.Furthermore,itisfoundthattheoptimaldamagetoleranceabilityisoptimizedwhenthenotchpositionislocatedattheTi-aluminidemulti-layeredpartduetothecrackdeflectionofmulti-layeredstructure.
简介:Inthispaper,theconceptoftheShortest-RouteTrafficMatrix(SRTM)wasfirstpresented,andthegeneralizedformulaforcomputingringcapacityrequirementinuseofSRTMisgiven.Then,anewcapacitydesignalgorithmwhichisbasedonSRTMwaspresentedforSynchronousDigitalHierarchical(SDH)Bi-directionalSelf-HealingRing(BSHR).ThealgorithmsimulationresultsdemonstratethatthisalgorithmisveryefficientforSDHBSHRcapacitydesignandcanmakelessprojectinvestmentandmakehighutilizationoflinesandequipment.Bymeansofthealgorithminthispaper,capacityoptimizationassignmentforSDHHierarchicalSelf-HealingRing(HSHR)andforATMVirtualPath(VP)-basedSelf-HealingRing(SHR)isalsodiscussed.
简介:BackgroundTreatmentofratswiththebeta-adrenergicagonistIsoprenaline(ISO)resultsincardiachypertrophyandmyocardialfibrosis.Inthepresentwork,weaimedtostudytheinvivoeffectsofISOonserumlevelsofmonocytechemoattractantprotein-1andtissueinhibitorofmatrixmetalloproteinasestypeIinWistarrats.MethodsISO(5mg·kg-1)orSalinewereinjectedsubcutaneouslyintoWistarratsonceadayfor3or7consecutivedays.Ventricularremodelingandcardiacfunctionwereevaluatedbyechocardiography.Sectionsofheartwerestainedwithhematoxylin-eosin(HE)forhistopathologyorwithMassonstrichromeforcollagenvisualization.Inaddition,hearttissueimmunohistochemistryforɑ-SMAwasalsoanalyzed.TheserumlevelsoftissueinhibitorofmatrixmetalloproteinasestypeI(TIMP-1)andmonocytechemoattractantprotein-1(MCP-1)weredeterminedbyLuminexmultiplextechnology.ResultsISOinducedcardiacdysfunctioninratsafter3or7daysoftreatment.ISOcausedsignificantincreaseofmyocardialdisorderandfibrosiswithincreasedɑ-SMAexpression.ISOtreatedaatsshowedasignificantincreaseintheserumlevelsofTIMP-1andMCP-1.ConclusionsOurstudysuggeststhatISOinducesprofoundcardiacremodelingaccompaniedwithincreaseofserumTIMP-1andMCP-1.
简介:Thecomplexnatureoflaser-materialinteractioncausesnon-stoichiometricablationofalloysamples.Thisisattributedtomatrixeffect,whichreducesanalyzingcapability.Toaddressthisissue,theanalyticalperformanceofthreedifferentnormalizationmethods,namelynormalizationwithbackground,internalnormalizationandthreepointsmoothingtechniquesatdifferentparametersettingsisstudiedforquantificationofAgandZnbyLaserinducedbreakdownspectroscopy(LIBS).TheLIBSspectraoffiveknownconcentrationofsilverzincbinarycompositeshavebeeninvestigatedatvariouslaserirradiances(LIs).CalibrationcurvesforbothAg(I)line(4d^105s^2S1/2→4d^105p^2P1/2at338.28nm)andZn(I)line(4s5s^3S1→4s4p^3P2at481.053nm)havebeendeterminedatLIof5.86×10^10Wcm^-2.SlopesofthesecalibrationcurvesprovidethevaluationofmatrixeffectintheAg–Zncomposites.Withcarefulsamplepreparationandnormalizationaftersmoothingatoptimumparametersetting(OPS),theminimizationofsamplematrixeffecthasbeensuccessfullyachieved.AgoodlinearityhasbeenobtainedinAgandZncalibrationcurveatOPSwhennormalizedthewholeareaofspectrumaftersmoothingandtheobtainedcoefficientsofdeterminationvalueswereR^2=0.995and0.998closerto1.Theresultsofmatrixeffecthavebeenfurtherverifiedbyanalysisofplasmaparameters.BothplasmaparametersshowednochangewithvaryingconcentrationatOPS.However,athighconcentrationofAg,theobservedsignificantchangesinbothplasmaparametersatcommonparametersettingPS-1andPS-2werethegestureofmatrixeffect.Inourcase,thebetteranalyticalresultswereobtainedatsmoothingfunctionwithoptimizedparametersettingthatindicatesitismoreefficientthannormalizationwithbackgroundandinternalnormalizationmethod.
简介:Ternarycomplexesofeuropiumandterbiumwithbenzoicacidand1,10-phenanthroline[RE(BA)3phen](BA=benzoatephen=1,10-phenanthroline)wereintroducedintoasilicamatrixbysol-gelmethod.Thethermalstabilityandluminescencebehaviorofthecomplexesinsilicagelswerestudiedincomparisonwiththecorrespondingsolid-statecomplexesbythermaldecomposition,excitationandemissionspectra.Thethermalstabilityofthecomplexesisenhancedinsilicagelmatrixandtheluminescenceremainesunchanged.
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