简介：AdeuteriumclusterjetproducedinthesupersonicexpansionintovacuumofdeuteriumgasatliquidnitrogentemperatureandmoderatebackingpressuresarestudiedbyRayleighscatteringtechniques.Theexperimentalresultsshowthatdeuteriumclusterscanbecreatedatmoderategasbackingpressuresrangingfrom8to23bar,andamaximumaverageclustersizeof350atomsperclusterisestimated.Thetemporalevolutionoftheclusterjetgeneratedatthebackingpressureof20bardemonstratesatwo-plateaustructure.Thepossiblemechanismresponsibleforthisstructureisdiscussed.Theformerplateauwithhigheraverageatomandclusterdensitiesismoresuitableforthegenerallaser-clusterinteractionexperiments.

简介：Inthispaper,thefocusdepthdistributionofearthquakeswitheachmagnitudehasbeenanalyzed.Statisticdatashowthatthelowermagnitudeis,thewiderfocusdepthdistributes.Withlargermagnitude,thefocustendstobeconcentratedinupperormiddlecrustallayers.Weanalyzedthecauseoffocusdepthdistributionandexplainedtheprecursormechanismofsmallandmoderateearthquakeswithoccurringconditionandcharacteristicsofstrongearthquakes.Theresultsofthispapermaybeappliedtodeterminerisksitesofstrongearthquakes.

简介：Currentdesigncriteriaandprinciplesofearthquakeengineeringdesignarereviewed,includingsafetyfactors,probabilisticapproach,andtwo-levelandmulti-levelfunctionaldesignideas.Themodernmulti-functionalideaisdiscussedingreaterdetails.Whendesigningastructure,itsresistancetoandtheintensityoftheearthquakeactionareconsidered.Theconsequenceoffailureofthestructureisconsideredonlythrougharoughandempiricalfactorofimportance,rangingusuallyfrom1.0to1.5.Thispapersuggestsamethodof'consequence-baseddesign,'whichconsiderstheconsequencesofmalfunctioninginsteadofsimplyanimportancefactor.Themainargumentforthismethodisthatdamagetoastructurelocatedindifferenttypesofsocietiesmayhaveverydifferentconsequences,whicharedependantonitsvalueandusefulnesstothesocietyandtheseismicityintheregion.

简介：无

简介：TheauthorsconsiderthemoderatedeviationsofhydrodynamiclimitforGinzburg-Landaumodels.ThemoderatedeviationprincipleofhydrodynamiclimitforaspecificGinzburg-Landaumodelisobtainedandanexplicitformulaoftheratefunctionisderived.

简介：让fn基于内核函数K和在d维的单位范围Sd拿值的独立、相等分布式的随机的变量的一个序列是方向性的数据的非参量的内核密度评估者?1。如果核功能是有围住的变化的功能，随机的变量的密度功能f是连续的，它被证明那，那么大的偏差原则和中等偏差原则为成立。关键词核密度评估者-方向性的数据-中等偏差-大偏差先生(2000)题目分类60F10-62F12由中国(资助号码10571139)的国家自然科学基础支持了

简介：在这份报纸，当错误形成一个严格地静止的混合序列时，为在一个线性模型的回归参数的M评估者的中等偏差被获得。结果被使用学习象Hubers评估者，Lp回归评估者，最少的广场评估者和最不绝对的偏差评估者那样的M评估者的许多不同类型。

简介：Onthebasisof10935broadbandvelocityrecordsof135earthquakes(ML3.0-6.4andepicentraldistanceof26-623km)occurredfromMay12toJune10in2008,whicharecollectedfrom27bedrockstationsincludedinSichuanEarthquakeMonitoringNetwork,thecorrespondingaccelerationrecordsareobtainedbyareal-timesimulationmethod.Thenbyregressionanalysisonthedata,therelationbetweenthepeakgroundaccelerationandvelocityattenuationofsmallandmoderatebedrockearthquakesoccurredinSichuanregionisacquired.AndtherelationisverifiedbyaM4.8earthquaketookplacerecentlyinWenchuan.Finally,theattenuationrelations,whicharecoincidenttothegeologicalconditionsinSi-chuanregion,areproposedbystudyingtherecordsfromSichuanearthquakenetwork.

简介：Boilingheattransferprocessisanalyzedinamoderatenarrowspaceconsistedoftwohorizontalplates,Themaindifferencebetweenthisprocessandtheconventionalunconfinedpoolboilingistheliquidsupplymechanismwhichisabsolutelypreventedbythegrowthofcoalescencebubblealongwiththeheatedsurfaceinthenarrowspace.Asaresult,themacrolayerbecomesthinnerduetotheevaporationoftheindividualbubbleswithinthemacrolayerduringtheperiodofbubblecoalescence,withorwithoutdryoutthatdependsonboththegapsizeofnarrowspaceandthesizeofheatedsurface.Foraspecifiedsizeoftheheatedsurface,theinitialthicknessoftheliquidlayerhasacriticalvaluewhichapproachesaconstantwhilethespaceheightislargerthanacriticalvalue.Theindividualbubblebehaviorsandtheheattransfercanbeconsideredasthesameasthatintheunconfinedpoolboiling,ifthespacegapislarge,However,theindividualbubblesdonotgenerateinthelastperiodofthebubblecoalescenceandalowermaximumheatfluxwillberesultedifthespacegapisreduced.Insuchacase,themacrolayerisdryout.

简介：Letfnbeanon-parametrickerneldensityestimatorbasedonakernelfunctionK.andasequenceofindependentandidenticallydistributedrandomvariablestakingvaluesinR.Thegoalofthisarticleistoprovemoderatedeviationsandlargedeviationsforthestatisticsupx∈R|fn(x)-fn(-x)|.

简介：Thechangelawsofintensityofnearly200moderate-smallearthquakeswithMs=2.0~5.5occurringontheChinesemainlandsince1954havebeenanalyzedandarecomparedwiththatofmoderatelystrongearthquakes(Ms≥5.0).Theresultsshowthatthereisquiteobviousregionalityinthestatisticallawsbybothmoderate-smallearthquakesandmoderatelystrongearthquakes:attenuationofintensityinEasternChinaisslowerthanthatinWesternChinaandtheratioofthemajoraxistotheminoraxisofiso-seismallinesinEasternChinaissmallerthanthatinWesternChina.Theresultsalsoshowthatforafixedmagnitudetheattenuationofintensityofmoderate-smallearthquakesisfasterwhenintensityishigherthanV+andslowerwhenintensityislowerthanV-incomparisonwiththatofmoderatelystrongearthquakes.Furthermore,therealsohavebeensomedifferencesintheaspectsasintensity-magnituderelationbetweenstatisticallawsofmoderate-smallearthquakesandmoderatelystrongearthquakes.Thesedi

简介：Traumaticbraininjury(TBI)isamajorpublichealthproblemthroughouttheworld.Morethan400000patientswithTBIintheUnitedStatesofAmericaandmorethanamillionpatientswithTBIinChinaareadmittedtohospitaleveryyear.HeadtraumaisalsoNo.1killerofyoungpeopleinthedevelopedcountriesaswellasinsomedevelopingcountries.Unfortunately,theoutcomeofpatientswithsevereTBIisstillpoorallovertheworld.ThemortalityofsevereTBIpatients(GCS3-8)inmajorityofhospitalsisover30%andverysevereTBIpatients(GCS3-5)isover80%withonly15%functionalrecovery.1,2However,recentadvanceincerebralprotectionbymild(35-33℃)tomoderatehypothermia(32-30℃)iscertainlyencouraging,whichbringsneurosurgeonsthehopetoimprovetheoutcomeofsevereheadinjuredpatients.

简介：

简介：AbstractImportance:The use of factor VIII (FVIII) concentrates under pharmacokinetic (PK) guidance has become the main approach for treatment of hemophilia. However, limited PK research has been conducted in Chinese pediatric patients.Objective:To investigate the PK parameters of various FVIII concentrates in Chinese pediatric patients.Methods:Seventy-nine patients were enrolled (28 treated with Kogenate FS®, 23 treated with Advate®, and 28 treated with GreenMono™). All enrolled patients participated in single-dose PK analysis after at least a 3-day washout period. Blood samples were collected predose, as well as at 1 h, 9 h, 24 h, and 48 h after infusion; FVIII levels were measured using a one-stage clotting assay. von Willebrand Factor Antigen (VWF:Ag) levels and blood types were also determined. PK parameters were evaluated by WAPPS-Hemo.Results:Mean values of terminal elimination half-life time (t1/2) for the Kogenate FS®, Advate®, and GreenMono™ FVIII groups were 12.24 h, 10.18 h, and 9.62 h; median clearance values were 4.16, 6.23, and 5.11 mL·kg-1·h-1; and median in vivo recovery values were 1.97, 1.55, and 1.61 IU/dL per IU/kg. Longer t1/2, higher in vivo recovery, and lower clearance were observed in patients with higher VWF:Ag level who were treated with recombinant concentrates.Interpretation:Chinese pediatric patients with hemophilia had FVIII PK characteristics similar to those previously observed in non-Chinese children, including large variation among individuals. VWF:Ag level and FVIII brand were associated with differences in FVIII PK. Thus, PK-guided dosing should be used to optimize individualized therapy in Chinese children.

简介：

简介：

简介：

简介：Objective:　Toexplorethevariantprocessesofcellapoptosisandtheinhibitingeffectofmoderatehypothermiaoncellapoptosisafterdiffusebraininjury.　　Methods:　ModelsofdiffusebraininjurywereinducedbythetraumadevicereportedbyMarmarou.1Atotalof128Wistarratsweredividedinto4groups:theuninjuredgroup(GroupA,n=8),theseverelyinjuredgroup(GroupB,n=60),themildlyinjuredgroup(GroupC,n=30)andthemildhypothermiagroup(GroupD,n=30).InGroupD,theseverelyinjuredratsweretreatedwithmoderatehypothermiatokeeptherectaltemperatureat32℃(standarddeviationfor0.1℃)for6hours.Thenthemorphosis,thecharacteristicsandthequantityofapoptoticcellsinthecerebralcortexandinthehippocampusregionsafterdifferentseveritiesofcraniocerebralinjurieswereobservedandcomparedunderanelectronicmicroscope,withterminaldeoxynucleotidylnickendlabeling(TUNEL)inDNAfragmentationandwithagarosegelelectrophoresis.　　Results:　TUNELshowedapoptoticcellsincreasedaccordingtotheinjuryseverity,andtheypeakedat48hoursafterinjuryandthendeclined.InGroupC,apoptosiswaslocatedintheCA2andCA3areasofthehippocampus.AndinGroupB,apoptosisincreasedevidently,andlocatedinthewholehippocampusandinthefrontalandparietalcortexregions.Thehypothermia-treatedratshadsomeapoptoticcells,too.However,evenat24,48and72hoursafterinjurythereweresignificantlyfewerapoptoticcellsinthecortexandinthehippocampusinGroupDthanthatinthenon-treatedgroups.Electronmicroscopyshowedthattheapoptoticcellswereroundandshrunkeninmorphologyandthenucleiwereroundandcondensedat24and48hoursafterinjury.Andtheapoptosisat48hourswasmoreseverethanthatat24hours.Thehypothermia-treatedratshadnoapoptoticcells.GelelectrophoresisshowedthatcharacteristicDNA“ladders”wereobservedinthecortexandinthehippocampusat48hoursafters

简介：Inthepaper,sourcemechanismsof33small-moderateearthquakesoccurredinYunnanaredeterminedbymodelingofregionalwaveformsfromYunnandigitalseismicnetwork.TheresultshowsthatmostearthquakesoccurredwithinorneartheChuandianrhombicblockhavestrike-slipmechanism.TheorientationsofmaximumcompressivestressesobtainedfromsourcemechanismarechangedfromNNW-SSNtoNSintheareasfromnorthtosouthoftheblock,andtensilestressesaremainlyinENE-WSWorNE-SE.IntheeasternTibetanPlateau,theorientationsofmaximumcompressivestressradiatetowardoutsidefromtheplateau,andthetensilestressorientationsmostlyparalleltoarcstructures.Near28°Ntheorientationsofbothmaximumcompressivestressandtensilestresschangedgreatly,andtheboundaryseemstocorrespondtothesouthwesternextendedlineofLongmenshanfault.OutsideoftheChuandianrhombicblock,theorientationsofPandTaxesaresomedifferentfromthosewithintheblock.Thecomparisonshowsthatthesourcemechanismofsmall-moderateeventspresentedinthepaperisconsistencewiththatofmoderate-strongearthquakesdeterminedbyHarvardUniversity,whichmeansthesourcemechanismofsmall-moderateeventscanbeusedtostudythetectonicstressfieldinthisregion.

简介：