简介：AIM:Toinvestigatetheaccuracyofendoscopicorbiopsydiagnosesofsuperficialnonampullaryduodenalepithelialtumors(NADETs).METHODS:Clinicopathologicaldatawerereviewedfor84superficialNADETsfrom74patientswhounderwentsurgeryorendoscopicresectionbetweenSeptember2002andAugust2014atasingleprefecturalcancercenter.SuperficialNADETsweredefinedaslesionsconfinedtothemucosaorsubmucosa.Demographicandclinicopathologicaldatawereretrievedfromcharts,endoscopicandpathologicreports.Endoscopicreportsincludedendoscopicdiagnosis,location,grosstype,diameter,color,andpresenceorabsenceofbiopsy.Endoscopicdiagnosesweremadebyanendoscopistinchargeoftheexaminationbeforebiopsyspecimenswereobtained.Endoscopicimageswereobtainedusingroutine,front-view,high-resolutionvideoendoscopy,andchromoendoscopywithindigocarminewasperformedforalllesions.Endoscopicimageswerereviewedbyatleasttwoendoscopiststoassessendoscopicfindingsindicativeofcarcinoma.Preoperativediagnosesbasedonendoscopyandbiopsyfindingswerecomparedwithhistologicaldiagnosesofresectedspecimens.Sensitivity,specificity,andaccuracywereassessedforendoscopicdiagnosisandbiopsydiagnosis.RESULTS:Themajority(81%)ofthelesionswerelocatedinthesecondportionoftheduodenum.Themedianlesiondiameterwas14.5mmaccordingtofinalhistology.Surgerywasperformedfor49lesionsfrom39patients,and35lesionsfrom35patientswereendoscopicallyresected.Finalhistologyconfirmed65carcinomas,15adenomas,and3hyperplasias.Afinaldiagnosisofduodenalcarcinomawasmadefor91%(52/57)ofthelesionsdiagnosedascarcinomabyendoscopyand93%(42/45)ofthelesionsdiagnosedascarcinomabybiopsy.Thesensitivity,specificity,andaccuracyofendoscopicdiagnoseswere80%,72%,and78%,respectively,whereasthoseofbiopsydiagnoseswere72%,80%,and74%,respectively.Preoperativediagnosesofcarcinomasweremadein88%(57/65)ofthecarcinomalesionsviaendoscopyorbiopsy.En