简介：and to make use of this or not according to need. Hanfeizi also had the same attitude .He advocated his ideas about the,one should know the dividing line of the encouragement and punishment and use these them wisely. The emperor should learn to get rid of the opponents and use law to rule the country so that all the citizen would know what they should do and what they should not. III Their different result ,In The Prince Niccolo Machiavelli presents a view of governing

简介：and would try every means to reach ones aims.3.On the image of emperor.In The Prince Niccolo Machiavelli presents a view of governing 摘要,one should know the dividing line of the encouragement and punishment and use these them wisely. The emperor should learn to get rid of the opponents and use law to rule the country so that all the citizen would know what they should do and what they should not.,state that is drastically different from that of humanists of his time. Machiavelli believes the ruling Prince should be the sole authority determining every aspect of the state and put in effect a policy

简介：one should know the dividing line of the encouragement and punishment and use these them wisely. The emperor should learn to get rid of the opponents and use law to rule the country so that all the citizen would know what they should do and what they should not.,Machiavelli further went on to question the loyalty of the citizens and advised the Prince that "...because men a wretched creatures who would not keep their word to you,In The Prince Niccolo Machiavelli presents a view of governing

简介：a letter by Machiavelli was discovered in which he reveals that he wrote The Prince to endear himself to the ruling Medici family in Florence. To liberate Italy from the influence of foreign governments,he adopted the same attitude with Hanfeizi towards how an emperor should rule his country. In this paper,From the experience Machiavelli learned that weak countries had no diplomatic relationship with other counties. In his work he put forward that the weakest thing in the world was the power that was exaggerated. He tried to persuade the emperor to make a strong army

简介：Machiavelli further went on to question the loyalty of the citizens and advised the Prince that "...because men a wretched creatures who would not keep their word to you,Machiavelli believed a secular form of government to be a more realistic type. His views were to the benefit of the prince,in helping him maintain power rather than to serve to the well being of the citizens. Machiavelli promoted his belief by stating

简介：Amongthemodernrhetoricaldevices,metonymyandsynecdochearetwoimportantfiguresofspeech,whichareanalogoustoeachotherforbothusethenameofonethingforthatofsomethingelse.Thatistosay,bothoftherhetoricaldevicesinvolvesubstitution.Thusthetwoconceptsareconfusing.Metonymyemphasizesonusingthenameofonethingforthatofsomethingelsewithwhichitisassociated.Synecdocheisafigureofspeechinwhichapartisusedforawhole,anindividualforaclass,amaterialforathing,orthereverseofanyofthese.Bymakingacomparativestudyofthesetwothroughtheconnotationandcategory,theauthorsummarizesthat:theyaretwoindependentfiguresofspeech.

简介：TibetanoperaisanethnicanduniquetheatricalgenreinthesystemofChineseoperas.AlltheethnicoperasinChinaaredirectlyorindirectlyakintoHanoperas,soisTibetanopera.Asamemberofthebigfamily,Tibetanoperanecessarilyabsorbssomeartis-

简介：ItisquitecommonthatCollegestudents’writingsareoftenloadedofordinarywordsandmonotonoussentencepatternsbecausetheyoftendeliberatelyavoidsomelanguagestructuresandconjunctions.ThiskindofsketchyandhollowwritingsmayhindertheimprovementofEnglishwritingskill.Thispaperfirstresearchesthisavoidancephenomenonfromthreeaspects:lexis,syntax,anddiscourse,thenexploresthereasonsbehindit,andfinallyputsforthsomeinstructivesuggestionsforimprovingthiscondition.

简介：Fortheconservativeandnon-conservativeschemesofnonlinearevolutionequations,bytakingthetwo-dimensionalshallowwaterwaveequationsasanexample,acomparativeanalysisoncomputationalstabilityiscarriedout.Therelationshipbetweenthenonlinearcomputationalstability,thestructureofthedifferenceschemes,andtheformofinitialvaluesisalsodiscussed.

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简介：one should know the dividing line of the encouragement and punishment and use these them wisely. The emperor should learn to get rid of the opponents and use law to rule the country so that all the citizen would know what they should do and what they should not.,Machiavelli further went on to question the loyalty of the citizens and advised the Prince that "...because men a wretched creatures who would not keep their word to you,In The Prince Niccolo Machiavelli presents a view of governing

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简介：双向强风是一条简单途径检测，注解，并且分析候选人orthologous或在一个单身者的paralogous序列去。这个过程通常被限制到设定的Perl脚本的领域，通常为象UNIX一样调节了环境。移植那些脚本到另外的操作系统涉及重新分解他们，并且另外有要求的图书馆的Perl编程环境的安装。克服这些限制，一条数据管道在Java被实现。这应用提交序列的二批到NCBI强风工具的本地版本，管理结果表，并且精制双向、简单的点击。变细长术语被纳入点击，几统计被导出，并且分子的进化率通过PAML被估计。结果被写给为进一步的分析打算的一套限定的文章表格。提供的图形的用户接口用这个应用程序允许一个友好相互作用，它被记录并且对在http://moodle.fct.unl.pt/course/view.php的下载可得到?在GNUGPL许可证下面的id=2079或https://sourceforge.net/projects/bidiblast/。

简介：a letter by Machiavelli was discovered in which he reveals that he wrote The Prince to endear himself to the ruling Medici family in Florence. To liberate Italy from the influence of foreign governments,he adopted the same attitude with Hanfeizi towards how an emperor should rule his country. In this paper,saw the political corruption in his country and put forward much useful advice to carry out reform.. Unfortunately the emperor of Han would not like to adopt his ideas and let his country wither away. However the emperor of Qinshihuang admired the talent of Hanfeizi and wanted to give him a position in Qin state. Although Qinshihuang finally killed Hanfeizi owing to listening to the unfaithful advice of Lisi.

简介：Machiavelli further went on to question the loyalty of the citizens and advised the Prince that "...because men a wretched creatures who would not keep their word to you,in helping him maintain power rather than to serve to the well being of the citizens. Machiavelli promoted his belief by stating,while kind mother has brute children. Both of them believed that the relationship among human beings was a kind of naked interest_oriented relationship. They make use of each other

简介：Anumberofphenomenaandprocessesingeosciencescanbesummarizedbysecondorderpartialdifferentialequations.Themajornumericalmethodsfortheirsolutionincludetheclassicalfinitedifferencemethodandthefiniteelementmethodnewlydevelopedinthelasttwoorthreedecades.Since1977theauthorhasprovedthatfortheLaplaceandPoissonequations,thesetwomethodsareidenticalandaredifferentonlyintheprocessofformulation.Fortransientproblems,suchasheatconductionintheearthandthegroundwaterandoil-gasunsteadyflowinporousmedia,therearesomedifferencesinresultinglinearalgebraiceuqations.Ingeneral,twomethodsgivesimilarresults,butwhenthetimestepisdecreasedtosomeextent,theresultingalgebraicequationwillbeconsistentwiththeanti-heatconductionequationratherthantheoriginalheatconductionequation.Thisisthereasonwhyunrealisticpotentialsareproducedbythefiniteelementmethod.Suchaproblemcanbeovercomebyusingthe

简介：ChinesedevelopmentassistanceistotallydifferentinnatureincomparisonwiththeaidofferedbytheUnitedStatesandJapan.TheU.S.seesitsaidasaformof'mercy'toless-developedcountriesandgivesitwithnumerousconditionsattached.Japanseemstomainlyuseittopursuecommercialinterests.Bycontrast,Chineseaidis,inessence,cooperationandmutualsupportbetweendevelopingcountries.ThisfundamentaldifferencehelpstoexplainwhyBeijing'saidissodifferentfromthatoftheWesterndonors.

简介：AbstractBackground:Cerebral cavernous malformations (CCMs), a major neurosurgical condition, characterized by abnormally dilated intracranial capillaries, result in increased susceptibility to stroke. KRIT1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3) have been identified as causes of CCMs in which at least one of them is disrupted in most familial cases. Our goal is to identify potential biomarkers and genetic modifiers of CCMs, using a global comparative omics approach across several in vitro studies and multiple in vivo animal models. We hypothesize that through analysis of the CSC utilizing various omics, we can identify potential biomarkers and genetic modifiers, by systemically evaluating effectors and binding partners of the CSC as well as second layer interactors.Methods:We utilize a comparative omics approach analyzing multiple CCMs deficient animal models across nine independent studies at the genomic, transcriptomic, and proteomic levels to dissect alterations in various signaling cascades.Results:Our analysis revealed a large set of genes that were validated across multiple independent studies, suggesting an important role for these identified genes in CCM pathogenesis.Conclusion:This is currently one of the largest comparative omics analysis of CCM deficiencies across multiple models, allowing us to investigate global alterations among multiple signaling cascades involved in both angiogenic and non-angiogenic events and to also identify potential biomarker candidates of CCMs, which can be used for new therapeutic strategies.

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