学科分类
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3 个结果
  • 简介:Inthehourstoweeksfollowingtraumaticspinalcordinjuries(SCI),biochemicalprocessesareinitiatedthatfurtherdamagethetissuewithinandsurroundingtheinitialinjurysite:aprocesstermedsecondaryinjury.Acrolein,ahighlyreactiveunsaturatedaldehyde,hasbeenshowntoplayamajorroleinthesecondaryinjurybycontributingsignificantlytobothmotorandsensorydeficits.Inparticular,effortshavebeenmadetoelucidatethemechanismsofacrolein-mediateddamageatthecellularlevelandtheresultingparalysisandneuropathicpain.Inthisreview,wewillhighlighttherecentdevelopmentsintheunderstandingofthemechanismsofacroleininmotorandsensorydysfunctioninanimalmodelsofSCI.Wewillalsodiscussthetherapeuticbenefitsofusingacroleinscavengerstoattenuateacrolein-mediatedneuronaldamagefollowingSCI.

  • 标签: 脊髓损伤 丙烯醛 运动 神经元损伤 靶标 治疗