简介：TheShanghaiCooperationOrganization(SCO),aregionalcooperativeorganizationthatstrandstheEurasiancontinent,hasavastrangeofcooperationandisfullofvitality.Intheeightyearssinceitsinception,ithasconstantlyimproveditsorgani-

简介：Wedescribethedesignoffourornithoptersranginginwingspanfrom10cmto40cm,andinweightfrom5gto45g.Thecontrollabilityandpowersupplyaretwomajorconsiderations,sowecomparetheefficiencyandcharacteristicsbetweendif-ferenttypesofsubsystemssuchasgearboxandtailshape.Ourcurrentornithopterisradio-controlledwithinbuiltvisualsensingandcapableoftakeoffandlanding.Wealsoconcentrateonitswingefficiencybasedondesigninspiredbyarealinsectwingandconsiderthataspectsofinsectflightsuchasdelayedstallandwakecaptureareessentialatsuchsmallsize.Mostimportantly,theadvanceratio,controlledeitherbyenlargingthewingbeatamplitudeorraisingthewingbeatfrequency,isthemostsignificantfactorinanornithopterwhichmimicsaninsect.

简介：Afierhavingexperiencedtwodecadesofsustainedhigh.economicqrnwthwillithppossibleforChinatoseecontinuedsustainedhigheconomicgrowthinanother10to20years?Followingtheeconomicslowdowninthepastfewyears,manyholdpessimisticviewsonthis.Inaninterviewwithacorresp...

简介：ObjectiveTo调查军事人员在位于不同区域的中国army.MethodsEleven军人撤退医院里支撑的眼睛损害的流行病学的特征为这研究被选择。我们考察了在2005年1月和2009年12月之间的军事人员支撑的眼睛损害的所有医药记录。Patients’信息是镇定的。所有数据被放进数据库并且statistically.ResultsTotally分析了有有眼睛损害(442只眼睛)的415个住院病人，他们的吝啬的年龄是24.40年。眼睛损害在这研究说明13.51%所有眼睛疾病。从2006～2009，眼睛损害的数字在他们之中逐渐地增加了，(42.17%)175在空闲被伤害预定，并且(34.94%)145在工作预定。22(5.30%)病人们在损害前有一个眼睛手术或眼睛疾病的历史。总共，246个病人(59.28%)在24个小时以内被送到撤退医院，(56.64%)64在损害以后在24个小时经历了手术。有389个病人(93.73%)，在1次就医。187只眼睛(42.31%)的视觉尖酸是等级1(5=20/40)在损害以后。什么时候排出，349只眼睛(78.96%)获得了在中国军队的很经常的发生和更多注意应该被付阻止它的损害有的等级1.ConclusionEye的视觉尖酸。

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简介：Recently,tosavethecurrentdrivepowerandtoobtainmorefavorableconfinementmeritforatokamakreactor,largefractionofbootstrapcurrentsustainedequilibriumhasattractedgreatinterestsboththeoreticallyandexperimentally.WeuseanpowerfulexpandingtechniqueandthetokamakorderingtoexpandtheGSh-Etoobtainaseriesofordinarydifferentialequationswhichallowfordifferentsetsofinputprofiles.Thefullybootstrapcurrentsustainedtokamakequilibriaarethensolvedanalytically.

简介：INTRODUCTIONPolyhydroxybutyrate(PHB)andit'scopolymerPHBVachievedbythebiosyntheticpathway,hasattractedmuchattentionasanalternationbiodegradablematerials.Theyhavetheexcellentbiocompatibilityandproperdegradationperiodsbyoptimizationofpertinentmolecularweightandcopolymercompositions.

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简介：用乳剂—溶剂挥发法制备硝苯地平的丙烯酸树脂缓释微球。微球中药物的释放速度随丙烯酸树脂ＥｕｄｒａｇｉｔＲＬ／ＲＳ比率的增加以及制备时搅拌速率的增加而增大，随内相聚合物浓度的增加及微球粒径的增加而减小，释药５０％所需时间与微球粒径呈良好线性。微球的释药速率也随药物含量的增加（从４．２％到１６．７％）而增大，并快于药物结晶的溶解速率，但药物含量达２６．６％时，微球释药速率明显下降并低于药物结晶的溶解速率。用差热分析和Ｘ射线衍射分析证明，药物含量为４．２，９．４和１６．７％的微球中药物完全是以非晶态分散的，而含药２６．６％的微球中有药物结晶存在。不同微球释药低于７０％时，释放方式均符合Ｈｉｇｕｃｈｉ时间平方根方程。

简介：Westudythetransitiontoturbulenceofchannelflowoffinite-sizeparticlesuspensionsatlowvolumefraction,i.e.,Φ≈0.001.ThecriticalReynoldsnumberabovewhichturbulenceissustainedreducestoRe≈1675,inthepresenceoffewparticles,independentlyoftheinitialcondition,avaluelowerthanthatofthecorrespondingsingle-phaseflow,i.e.,Re≈1775.Inthedilutesuspension,theinitialarrangementoftheparticlesisimportanttotriggerthetransitionatafixedReynoldsnumberandparticlevolumefraction.Asinsinglephaseflows,streamwiseelongateddisturbancesareinitiallyinducedintheflow.Ifparticlescaninduceobliquedisturbanceswithhighenoughenergywithinacertaintime,thestreaksbreakdown,flowexperiencesthetransitiontoturbulenceandtheparticletrajectoriesbecomechaotic.Otherwise,thestreaksdecayintimeandtheparticlesimmigratetowardsthechannelcoreinalaminarflow.

简介：Aseriesofbiodegradablehydrogelsbasedondextranandpoly(L-glutamicacid)werefabricatedforeffectivevancomycinloadingandrelease.Thepreparationofhydrogelswassimplyachievedbyphotocross-linkingofmethacrylateddextranandpoly(L-glutamicacid)-g-hydroxyethylmethacrylate(PGH)inthepresenceofphotoinitiatorI2959.ThestructuresofhydrogelswerecharacterizedbyFTIRandSEM.Theswellingandenzymaticdegradationbehaviorsofhydrogelswereexaminedtobedependentonthepoly(L-glutamicacid)contentinthehydrogels.Thehighercontentofpoly(L-glutamicacid)inthegel,thehigherswellingratioandquickerdegradationwereobserved.Moreinterestingly,thehydrogelwithhigherPGHratioshowedhighervancomycin(VCM)loadingcontent,whichmightbeduetotheelectrostaticinteractionbetweencarboxylategroupsinhydrogelandammoniumgroupofVCM.InvitrodrugreleasefromtheVCM-loadedhydrogelsinaqueoussolutionexhibitedsustainedreleaseofVCMupto72h,whiletheinvitroantibacterialtestbasedontheVCM-loadedhydrogelshowedanefficientMethicillin-ResistantS.aureus(MRSA)inhibitionextendingoutto7days.Theseresultsdemonstratedthatthebiodegradablehydrogelswhichformedbyinsituphoto-crosslinkingwouldbepromisingasscaffoldsorcoatingsforlocalantibacterialdrugreleaseintissueengineering.

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简介：降水的变化特征在冬季期间(在10月和下列三月之间，此后被叫作“就冬季”)在广东省在过去的50年期间(从1957～2006)并且与和平的SST的关系用实验直角的功能(文件结束)分析，小浪分析，和关联分析的方法被学习。结果证明广东降水在冬季期间展出40年和2年的伪周期的重要摆动；降雨比从1970年代中是从到1970年代并且从到礼品的1990年代的结束的开始的1950年代的结束的更少到1990年代中。持续干旱的频率多于在冬季期间泛滥支撑。广东降水在期间这次时期在到赤道的中央、东方的和平的SST的显著地积极的关联，但是在与菲律宾的海的西方、北的和平的SST东方的显著地否定的关联。61.5%持续干旱发生在Ni(n)o3.4索引的否定异例的阶段并且38.5%在积极的阶段。大气的循环的合成分析为与持续干旱联系的Ni(n)o3.4区域的积极、否定的阶段被执行。结果证明一个弱极的旋涡，在欧洲的强壮的马槽和一条山脉接近巴尔克哈什·莱克，活跃冷空气和在底层控制广东的一致的在北方的风异例，在亚洲大陆的低中间的纬度的不活跃的西的低骚乱，并且一个弱南部的分支西的马槽，都是为持续干旱的相互的原因。

简介：Purpose:Thepurposeofthisstudywastocomparethecoordinationbetweenthetrunkandthepelvisduringasustainedasymmetricrepetitiveliftingtaskbetweenagroupwithahistoryoflowbackpain(LBP;HBP)andagroupwithnohistoryofLBP(NBP).Methods:Volunteerslifteda11-kgboxfromankleheightinfronttoashelf45°off-centeratwaistheight,andloweredittothestartpositionat12cycles/minfor10min.Liftingsidewasalternatedduringthetrial.Continuousrelativephasewasusedtocalculatecoordinationbetweenthepelvisandtrunkrotationatthebeginning(Min1),middle(Min5),andendofthebout(Min9).Results:Whiletherewerenomaineffectsforgroup,asignificantinteractionbetweentimeandgroupindicatedthat,inthefrontalplane,theNBPgroupcoordinationwasmoreanti-phasetowardtheendofthebout,withnosuchdifferencesfortheHBPgroup.Analysisofsagittal-axial(bendandtwist)coordinationrevealedtheHBPgroupcoordinationwasmorein-phaseattheendoftheboutovertheentirecycleandfortheliftingphasealone,withnosuchdifferencesfortheNBPgroup.Conclusion:DifferencesbetweengroupsdemonstrateresidualconsequencesofLBPinanoccupationalscenario,eventhoughtheHBPgroupwaspain-freefor>6monthspriortodatacollection.Morein-phasecoordinationintheHBPgroupmayrepresentacoordinationpatternanalogousto'guardedgait'whichhasbeenobservedinotherstudies,andmaylendinsightastowhytheseindividualsareatincreasedriskforre-injury.

简介：瞄准：估计临床，生物化学并且virological在长期的丙肝(CHC)的长期的结果有在加ribavirin的peginterferon(PEG-IFN)以后的持续virological回答(SVR)的病人联合治疗。方法：有在有PEG-IFN正ribavirin的治疗以后的SVR的一百和53个病人在一个单个西班牙的中心在5年的后续研究被包括，基于标准临床的实践。临床的回忆，生物化学的分析，丙肝病毒RNA和alpha-fetoprotein测量，ultrasonography和短暂elastography每年被执行。结果：153个病人的吝啬的后续经期是76??敦瑥吗？

简介：AbstractBackground:Soil-transmitted helminths (STH) infections still present a global health problem. Mass drug administration (MDA) is a widely applied strategy to reduce morbidity and mortality caused by STH. Yet, this approach has some shortcomings. In this study, we analyzed the impact of a multi-intervention integrated deworming approach including MDA, health education (HE), and environmental sanitation improvements (ESI) for sustained STH control in Jiangsu Province of China that was applied from 1989 to 2019.Methods:Data, including infection rate of STH, medications used, coverage of the medication, non-hazardous lavatory rate, and household piped-water access rate in rural areas, and actions related to HE and ESI were collected (from archives) and analyzed in this retrospective descriptive study. Pearson’s correlation analysis was applied to test correlations.Results:There was a dramatic decline in the infection rate of STH from 1989 (59.32%) to 2019 (0.12%). From 1995 to 1999, MDA and HE were recommended in rural areas. A negative correlation was observed between infection rate and medication from 1994 to 1998 (r= - 0.882, P= 0.048). From 2000 to 2005, targeted MDA was given to high-risk populations with HE continuously promoting good sanitation behaviors. From 2006 to 2014, targeted MDA+ HE and ESI were used to consolidate the control effect. ESI was strengthened from 2006, and a negative correlation was observed between the coverage rate of the non-hazardous lavatory and the infection rate from 2006 to 2019 (r= - 0.95, P < 0.001). The targeted MDA was interrupted in 2015, while continuous efforts like HE and ESI contributed in sustaining STH control.Conclusions:Multi-intervention integrated deworming strategy contributes to the reduction of STH infections. This approach is a valuable example of how different interventions can be integrated to promote durable STH control.

简介：AbstractBackground:Intensive therapy with disease modifying anti-rheumatic drugs (DMARDs) has been reported to improve the outcomes of rheumatoid arthritis (RA). However, real-world study on the effect of intensive therapy on RA sustained remission is still lacking. This study aimed to investigate the outcome of sustained intensive DMARD therapy (SUIT) for RA in a real-world 5-year consecutive cohort.Methods:Based on a consecutive cohort of 610 out-patients with RA, remission of RA was assessed in 541 patients from 2012 to 2017, by dividing into SUIT, non-SUIT, and intermittent SUIT (Int-SUIT) groups. Changes in the disease activity scores were evaluated by 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR), 28-joint disease activity score based on C-reactive protein (DAS28-CRP), and clinical deep remission criteria (CliDR). Cumulative remission rates between different groups were compared using Kaplan-Meier curves and predictive factors of sustained remission were identified by univariate and multivariate logistic regression analysis.Results:The remission rates of the SUIT group decreased from 12.0% (65/541) to 5.6% (20/359) based on DAS28-ESR, from 14.0% (76/541) to 7.2% (26/359) based on DAS28-CRP, and from 8.5% (46/541) to 3.1% (11/359) based on CliDR, respectively, with a gradually decreasing trend during the 5 years. The SUIT regimen led to a significantly higher cumulative remission rate than non-SUIT regimen based on DAS28-ESR (39.7% vs. 19.5%, P = 0.001), DAS28-CRP (42.0% vs. 19.6%, P = 0.001), and CliDR (24.5% vs. 8.7%, P = 0.001). The cumulative remission rates of patients treated with SUIT regimen were significantly higher than those treated with Int-SUIT regimen based on DAS28-ESR (39.7% vs. 25.7%, P = 0.043) and CliDR (24.5% vs. 14.2%, P = 0.047), but there was no significant difference between the two groups based on DAS28-CRP (42.0% vs. 27.4%, P = 0.066). Multivariate logistic regression analysis showed that the use of SUIT regimen was an independent favorable predictor according to different remission definitions (for DAS28-ESR: odds ratio [OR], 2.215, 95% confidence interval [CI]: 1.271-3.861, P = 0.005; for DAS28-CRP: OR, 1.520, 95% CI: 1.345-1.783, P = 0.002; for CliDR: OR, 1.525, 95% CI: 1.314-1.875, P= 0.013).Conclusion:Sustained intensive treatment of RA is an optimal strategy in daily practice and will lead to an increased remission rate.

简介：AbstractBackground:Secukinumab demonstrated sustained efficacy in patients with ankylosing spondylitis (AS) through 5 years in pivotal Phase III studies. Here, we present efficacy and safety results (52-week) of secukinumab in patients with AS from the MEASURE 5 study.Methods:MEASURE 5 was a 52-week, Phase III, China-centric study. Eligible patients were randomly assigned (2:1) to receive subcutaneous secukinumab 150 mg or placebo weekly for the first five doses and then once every 4 weeks (q4w). All placebo patients switched to secukinumab 150 mg q4w starting at Week 16. Primary endpoint was Assessments of SpondyloArthritis international Society (ASAS) 20 at Week 16. Randomization was stratified by region (China vs. non-China).Results:Of 458 patients (secukinumab 150 mg, N= 305; placebo, N= 153) randomized, 327 (71.4%) were from China and 131 (28.6%) were not from China. Of these, 97.7% and 97.4% patients completed Week 16 and 91.1% and 95.3% (placebo-secukinumab) patients completed Week 52 of treatment. The primary endpoint was met; secukinumab significantly improved ASAS20 response at Week 16 vs. placebo (58.4% vs. 36.6%; P < 0.0001); corresponding rate in the Chinese population was 56.0% vs. 38.5% (P < 0.01). All secondary efficacy endpoints significantly improved with secukinumab 150 mg in the overall population at Week 16; responses were maintained with a trend toward increased efficacy from Week 16 to 52. No new or unexpected safety signals were reported up to Week 52.Conclusions:Secukinumab 150 mg demonstrated rapid and significant improvement in signs and symptoms of AS. Secukinumab was well tolerated and the safety profile was consistent with previous reports. Efficacy and safety results were comparable between the overall and Chinese populations.Trial registration:ClinicalTrials.gov, NCT02896127; https://clinicaltrials.gov/ct2/show/NCT02896127?term=NCT02896127&draw= 2&rank=1.

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