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简介：●FromthestartofnationwidefundraisingforpowerconstructionaftertheDocumentNo.111issuedbytheStateCouncilin1987tothestartofpowerinstitutionalreformearlythiscentury,duringthese20years,China'spowerindustrydevelopedrapidlyandmadegreatachievements.●The20-yearhistoryofraisingfundsforpowerconstructionindicatesthatthispolicyisverywiseandcorrect.Itarousedenthusiasmfromboththecentralgovernmentandthelocalgovernment,andcontributedgreatlytothehis...

简介：Inrecentyears,althoughcollegestudentshaveacquiredahighlevelofproficiencyinEnglishreading,theyhavemadeverylittleadvancementinEnglishwriting.ThisisduetothefactthatinadequateimportanceisattachedtowritingintheteachingofEnglish,andthatstudentshaverathervagueideasabouttheroleofwritinginforeignlanguagelearningandaboutthediffer-entdiscoursepatternsexistingbetweenEnglishandChinese.Thus,thispapersuggeststhat,inordertoimprovestudents’writingability,twowaysbeadoptedtoraisestudents’awarenessoflearningtowrite:1)integratingtheproduct-orientedap-proachwiththeprocess-orientedapproach;2)usingstudents’readingasawritingsource.

简介：Therehavebeenexponentialgainsinimmuno-oncologyinrecenttimesthroughthedevelopmentofimmunecheckpointinhibitors.AlreadyapprovedbytheU.S.FoodandDrugAdministrationforadvancedmelanomaandnon-smallcelllungcancer,immunecheckpointinhibitorsalsoappearstohavesignificantantitumoractivityinmultipleothertumortypes.Anexcitingcomponentofimmunotherapyisthedurabilityofantitumorresponsesobserved,withsomepatientsachievingdiseasecontrolformanyyears.Nevertheless,notallpatientsbenefit,andeffortsshouldthusnowfocusonimprovingtheefficacyofimmunotherapythroughtheuseofcombinationapproachesandpredictivebiomarkersofresponseandresistance.Therearemultiplepotentialrationalcombinationsusinganimmunotherapybackbone,includingexistingtreatmentssuchasradiotherapy,chemotherapyormolecularlytargetedagents,aswellasotherimmunotherapeutics.Theaimofsuchantitumorstrategieswillbetoraisethetailonthesurvivalcurvebyincreasingthenumberoflongtermsurvivors,whilemanaginganyadditiveorsynergistictoxicitiesthatmayarisewithimmunotherapycombinations.Rationaltrialdesignsbasedonaclearunderstandingoftumorbiologyanddrugpharmacologyremainparamount.Thisarticlereviewsthebiologyunderpinningimmuno-oncology,discussesexistingandnovelimmunotherapeuticcombinationscurrentlyindevelopment,thechallengesofpredictivebiomarkersofresponseandresistanceandtheimpactofimmuno-oncologyonearlyphaseclinicaltrialdesign.

简介：Eveninclasseswhichstressoralpractice,theexplicitteachingofgrammarstillhasaroletoplay.EvelynDomanexplainswhyandpresentssomepracticalactivitieswhichintegrategrammarteachingwithcommunicativetasksinthegrammaticalconsciousness-raisingapproach.IntroductionTheroleofgrammarintheforeignlanguageclassroomhasbeendebatedbothlongandhard.Theoriesaboutteachinggrammarhavecoveredallrangesofthespectrum,goingfromplayingamajorroletobasicallyplayingnoroleatall.Today,CommunicativeLanguageTeaching(CLT)istheforerunnerintheTESL/TEFLcommunity.Yet,evenwithintheCLTframework,thecontroversyovertheteachingofgrammarcontinues.Manypeoplestillassertthatgrammarbegivenitsplace.Itooamamongthesepeople,especiallyinEFLenvironments,suchasinmypreviousteachingsituationsinSouthKorea.

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