简介：AIMTo比较在两个的灌注由使用光连贯断层摄影术angiography(OCTA)与正常控制组一起单方的自发的有斑点的洞(IMH)看的眼的神经头(ONH)并且调查它的correlationship，有斑点的血perfusion.METHODSWe表现了包括了19个病人与的未来、代表性的研究完整厚度单方IMH和24匹配年龄、匹配性的控制。所有参加者收到了OCTA测试。ONH灌注被peripapillary和全部的区域在脸(peripapillary和眼的圆盘的和)评估。在ONH和parafovea之间的潜在的correlationship被暗示。所有数据用介绍的ONH的nonparametrictest.RESULTSThe平均数值被执行那正常控制>IMH>未受影响的眼睛。一个统计变化在这个区域在三个组之间被发现时间(P=0.007)。容器密度著名地在层上减少了表面，深并且在IMH的parafovea区域的脉络膜组。关联词系数在脸和深视网膜完全分别地显示出那：r=0.528，peripapillary和深视网膜：r=0.525，在脸和choriocapillaries整个：r=0.569，peripapillary和choriocapillaries：r=0.504.CONCLUSIONOur学习在IMH眼睛在IMH病人和ONH的容器密度的两只眼睛表明减少的ONH容器密度断然在parafoveal与毛状的视网膜和choriocapillary被相关。容器密度的减小可以在IMH眼睛显示hypoperfusion。

简介：Thispaperproposesamorerealisticmathematicalsimulationmethodtoinvestigatethedynamicprocessoftumourangio-genesisbyfullycouplingthevesselgrowth,tumourgrowthandassociatedbloodperfusion.Thetumourgrowthandangiogenesisarecoupledbythechemicalmicroenvironmentandthecell-matrixinteraction.Thehaemodynamiccalculationiscarriedoutonthenewvasculature,andanestimationofvesselcollapseismadeaccordingtothewallshearstresscriterion.Theresultsareconsistentwithphy...

简介：AbstractTwin reversed arterial perfusion sequence, a severe and unique complication of monochorionic multiple pregnancy, is characterized by vascular anastomosis and abnormal or absent cardiac development in the twins. This article reviewed its pathogenesis, prenatal ultrasound diagnosis, and management. The pump twin’s chances for survival can be maximized by proper management. The optimal timing of the interventions remains a debate, although the latest studies encourage early intervention, i.e., in the first trimester. The most preferred approach is to interrupt the vascular supply to the acardius, such as through ultrasound-guided laser coagulation and radiofrequency ablation of the intrafetal vessels.

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简介：Inrecentyearsthepediclescrewsystemhasbeenwidelyusedintreatingthoracolumbarvertebralfractures.Theeffecttorecovertheinjuredvertebraeheight,thespinalphysiologicalcurveandtodecompressvertebralcanalhasbeenconfirmed.Buttheproblemsofinternalfixationbending,looseningandbreaking,whichresultinthelossofthevertebralheightandspinalangulationdeformity,arequitecommonandcausealotofdifficultiesforsurgeons.Tosolvetheseproblemsanddecreasethesequelaefromtreatingthoracolumbarvertebraefractureswithvertebralpediclescrewsystem,wehavetriedusingvertebralpediclescrewsystemplusACPCperfusiontotreat18patientswiththoracolumbarvertebralfractures.Satisfactoryresultshavebeenobtained.

简介：客观：在山羊胫节在外皮的骨头灌注上把点contact-dynamiccompression板(PC-DCP)和它的效果的机械性质与动态压缩盘子(DCP)的作比较。方法：二十匹配的新鲜山羊胫节被使用。一个横向的破裂模型被建立。有在骨折结束之间的3mm间隙星际的破裂分别地与DCP和PC-DCPs服从于固定，然后，thefour指弯曲测试和扭转测试被进行把PC-DCP的机械性质与DCP的作比较。另一13只性成熟的山羊与DCPsand经历了固定PC-DCPs，分别地在未经触动的双边的胫节中间柄。Ischemic地区在四个次点被观察(1天，在操作以后的2,6，和12个星期)用disulphine蓝染色技术。结果：在机械性质没有重要差别，例如拐弯抵抗和扭转抵抗，在DCP和PC-DCPs之间。有天，在操作以后的2，和6个星期在DCP固定的方面上，在坚持的板下面的外部外皮的骨头局部缺血，和这个条件没在操作以后逆行直到12个星期。在PC-DCP固定的方面上，然而，外皮的骨头局部缺血仅仅在螺丝钉洞并且在PC坚果的接触地点的圆周发生了1天在操作，和它在操作以后消失在2个星期以后。结论：PC-DCP有类似的简历DCP的机械性质，但是比常规盘子对本地骨头血循环不太有害。

简介：ThepurposeofthisstudywastodesignabioreactorforbioarLificialliverandstudyitsefficacythroughinvitroexperiment;testifiedthesafetyandefficacyoftheBALthroughtreatmentwithBALonacutefulminantischemichepaticfailurecaninemodels.

简介：Neurochirurgie,2008Jun21.INTRODUCTION:Neoangiogenesisisacriticalfeaturethatcandifferentiatehigh-gradefromlow-gradeglioma.Conven-tionalMRimagingdoesnotassessthishistologicalfeatureaccurately.Thegoalofthisstudywastoevaluatethegaininrel-ativecerebralbloodvolumemeasurementusingperfusionMRIinthemanagementofcerebralgliomas.MATERIALSAND

简介：Objective:Toinvestigatetheinfluenceofintracranialpressure(ICP)andcerebralperfusionpressure(CPP)onneurologicaldeteriorationandoutcomeofseveretraumaticbraininjury(STBI).Methods:Atotalof245patientswithseveretraumaticbraininjurywerestudiedretrospectivelywithunivariateandmultivariatestudiestoevaluatethecontributionofICP/CPPtoneurologicaldeteriorationandoutcome.Results:Themortalityratesrosefrom16.2%in142patientswhosecourseofdiseasewassmoothto66.7%in103patientswhosufferedfromneurologicaldeterioration.Correspondingly,thefavorableoutcomefallfrom54.2%inthepatientswithoutneurologicaldeteriorationto18.3%inthosewithneurologicaldeterioration.Inthepatientswithclinicalevidenceofneurologicaldeterioration,therelativeinfluenceoftheICPandtheCPPonoutcomewasassessed.Themosepowerfulpredictorsofneurologicaldeteriorationwasthepresenceofintracranialhypertension(ICP>30mmHg,1mmHg=0.133kPa).TheCPPalsohadaprognosticpoweronneurologicaldeteriorationwhenitslevellessthan60mmHg.Conclusions:Itsuggeststhatit'sveryimportanttolowertheintracranialhypertensionandkeeptheCPPnotlessthan60mmHgduringthetreatmentofSTBI.

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简介：AbstractBackground:Delayed graft function (DGF) is the main cause of renal function failure after kidney transplantation. This study aims at investigating the value of hypothermic machine perfusion (HMP) parameters combined with perfusate biomarkers on predicting DGF and the time of renal function recovery after deceased donor (DD) kidney transplantation.Methods:HMP parameters, perfusate biomarkers and baseline characteristics of 113 DD kidney transplantations from January 1, 2019 to August 31, 2019 in the First Affiliated Hospital of Xi’an Jiaotong University were retrospectively analyzed using univariate and multivariate logistic regression analysis.Results:In this study, the DGF incidence was 17.7% (20/113); The multivariate logistic regression results showed that terminal resistance (OR: 1.879, 95% CI 1.145-3.56) and glutathione S-transferase (GST)(OR = 1.62, 95% CI 1.23-2.46) were risk factors for DGF; The Cox model analysis indicated that terminal resistance was an independent hazard factor for renal function recovery time (HR = 0.823, 95% CI 0.735-0.981). The model combining terminal resistance and GST (AUC = 0.888, 95% CI: 0.842-0.933) significantly improved the DGF predictability compared with the use of terminal resistance (AUC = 0.756, 95% CI 0.693-0.818) or GST alone (AUC = 0.729, 95% CI 0.591-0.806).Conclusion:According to the factors analyzed in this study, the combination of HMP parameters and perfusate biomarkers displays a potent DGF predictive value.

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简介：Objective:Thisstudyinvestigatedthecapabilityofdual-energyspectralcomputedtomography(CT)toquantitativelyevaluatelungperfusiondefectsthatareinducedbycentrallungcancer.Methods:Thirty-twopatientswithcentrallungcancerunderwentCTangiographyusingspectralimaging.Aunivariategenerallinearmodelwasconductedtoanalyzethevarianceofiodineconcentration/CTvaluewiththreefactorsoflungfields.Apairedt-testwasusedtocompareiodineconcentrationsandCTvaluesbetweenthedistalendoflungcancerandthecorrespondingareainthecontralateralnormallung.Results:Iodineconcentrationsincreasedprogressivelyinthefar,intermediateandneargroundsidesinthenormallungfieldsat0.60±0.28,0.93±0.27and1.25±0.38mg/mL,respectively(P<0.001).ThesametrendwasobservedfortheCTvalues[–(840.64±49.08),–(812.66±50.85)and–(760.83±89.17)HU,P<0.001].Theiodineconcentration(0.70±0.42mg/mL)ofthelungfieldinthedistalendoflungcancerwassignificantlylowerthanthecorrespondingareainthecontralateralnormallung(1.19±0.62mg/mL)(t=–7.23,P<0.001).However,theCTvalueoflungfieldinthedistalendoflungcancerwassignificantlyhigherthanthecorrespondingareainthecontralateralnormallung[–(765.29±93.34)HUvs.–(800.07±76.18)HU,t=3.564,P=0.001].Conclusions:SpectralCTimagingbasedonthespectraldifferentiationofiodineisfeasibleandcanquantitativelyevaluatepulmonaryperfusionandidentifyperfusiondefectsthatareinducedbycentrallungcancer.SpectralCTseemstobeapromisingtechniqueforthesimultaneousevaluationofbothmorphologicalandfunctionallunginformation.

简介：Objective:Toevaluatetheeffectsofhyperbaricoxygen(HBO)therapyonpatientswithpostbraininjuryneuralstatus.Methods:Twoto4coursesofHBOtherapyand/ormedicationswereusedtotreat320patientswhowererandomlydividedintotwogroups.Assessmentwasmadewith99mTc-ethylcysteinatedimer(99mTc-ECD)singlephotonemissioncomputedtomography(SPECT)beforeandaftertreatment.Results:TherewasasignificantdifferencebetweentheHBOtherapygroupandthenon-HBOtherapygroup.HBOtherapywassuperiortomedicationtreatmentaloneintherecoveryofclinicalsymptoms,controlofepilepsy,andresolutionofhydrocephalus(P<0.01).Conclusions:HBOtherapyhasspecificcurativeeffectsonpatientswithpostbraininjuryneuralstatus,and99mTc-ECDSPECTcouldplayanimportantroleindiagnosingpostbraininjuryneuralstatusandmonitoringthetherapeuticeffectsofHBO.

简介：AbstractBackground:The peripheral perfusion index (PI), as a real-time bedside indicator of peripheral tissue perfusion, may be useful for determining mean arterial pressure (MAP) after early resuscitation of septic shock patients. The aim of this study was to explore the response of PI to norepinephrine (NE)-induced changes in MAP.Methods:Twenty septic shock patients with pulse-induced contour cardiac output catheter, who had usual MAP under NE infusion after early resuscitation, were enrolled in this prospective, open-label study. Three MAP levels (usual MAP -10 mmHg, usual MAP, and usual MAP +10 mmHg) were obtained by NE titration, and the corresponding global hemodynamic parameters and PI were recorded. The general linear model with repeated measures was used for analysis of variance of related parameters at three MAP levels.Results:With increasing NE infusion, significant changes were found in MAP (F = 502.46, P < 0.001) and central venous pressure (F = 27.45, P < 0.001) during NE titration. However, there was not a significant and consistent change in continuous cardiac output (CO) (F = 0.41, P = 0.720) and PI (F = 0.73, P = 0.482) at different MAP levels. Of the 20 patients enrolled, seven reached the maximum PI value at usual MAP -10 mmHg, three reached the maximum PI value at usual MAP, and ten reached the maximum PI value at usual MAP +10 mmHg. The change in PI was not significantly correlated with the change in CO (r = 0.260, P = 0.269) from usual MAP -10 mmHg to usual MAP. There was also no significant correlation between the change in PI and change in CO (r = 0.084, P = 0.726) from usual MAP to usual MAP +10 mmHg.Conclusions:Differing MAP levels by NE infusion induced diverse PI responses in septic shock patients, and these PI responses may be independent of the change in CO. PI may have potential applications for MAP optimization based on changes in peripheral tissue perfusion.

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简介：ObjectivesTodevelopasimple,accurateandreproduciblemethod,whichcombinesmacroandhistopathologicaltechniquesfordeterminingthedegreeoflipiddepositioningeneticallymodifiedmice.MethodTheentireaortasfromC57BL/6,ldlr-/-andapoE-/-micewerestainedwithSudanⅣusingeitherinvivoperfusionortraditionalinvitroenfacestainingtechniques.Histologicalsectionsofaorticrootandheartswereembeddedintissuefreezingmediumandcutwithacryostat,thenstainedwithOilRedO.Thecalculatedaorticrootareabasedontheaorticrootcircumferencewasusedtoreducemeasurementerrors.ResultsTheinvitroenfacestainingcanstainallfat,whichincludetheadventitialtissuearoundaorta.Howevertheinvivoperfusionstainingcanspecificallystainthefattydepositioninsideofaorta.Bothentireaortaandaorticrootsectionstainingshowedthattherewasahighlysignificantincreaseinfattydepositionintheaortasofthegeneticmodifiedmice.Althoughallmicegeneticbackgroundwassame,theapoE-/-micehadlargeratheroscleroticlesionsthanldlr-/-mice.ConclusionsThenewinvivoperfusionmethodismoreaccuratethantheinvitroenfacemethod.Thecombinationofthesemacroandmicroscopictechniquesovercomestheshortcomingsoftheearlierpublishedmethodswhicharegenerallylimitedtothemeasurementoffattyredstainingareasonly,neglectingnon-specificadventitialfatstainingaroundaortaandaorticrootsectiontissuedistortion.

简介：AbstractBackground:Pre-operative non-invasive histological evaluation of hepatocellular carcinoma (HCC) remains a challenge. Tumor perfusion is significantly associated with the development and aggressiveness of HCC. The purpose of the study was to evaluate the clinical value of quantitative liver perfusion parameters and corresponding histogram parameters derived from traditional triphasic enhanced computed tomography (CT) scans in predicting histological grade of HCC.Methods:Totally, 52 patients with HCC were enrolled in this retrospective study and underwent triple-phase enhanced CT imaging. The blood perfusion parameters were derived from triple-phase CT scans. The relationship of liver perfusion parameters and corresponding histogram parameters with the histological grade of HCC was analyzed. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal ability of the parameters to predict the tumor histological grade.Results:The variance of arterial enhancement fraction (AEF) was significantly higher in HCCs without poorly differentiated components (NP-HCCs) than in HCCs with poorly differentiated components (P-HCCs). The difference in hepatic blood flow (HF) between total tumor and total liver flow (ΔHF = HFtumor -HFliver) and relative flow (rHF = ΔHF/HFliver) were significantly higher in NP-HCCs than in P-HCCs. The difference in portal vein blood supply perfusion (PVP) between tumor and liver tissue (ΔPVP) and the ΔPVP/liver PVP ratio (rPVP) were significantly higher in patients with NP-HCCs than in patients with P-HCCs. The area under ROC (AUC) of ΔPVP and rPVP were both 0.697 with a high sensitivity of 84.2% and specificity of only 56.2%. The ΔHF and rHF had a higher specificity of 87.5% with an AUC of 0.681 and 0.673, respectively. The combination of rHF and rPVP showed the highest AUC of 0.732 with a sensitivity of 57.9% and specificity of 93.8%. The combined parameter of ΔHF and rPVP, rHF and rPVP had the highest positive predictive value of 0.903, and that of rPVP and ΔPVP had the highest negative predictive value of 0.781.Conclusion:Liver perfusion parameters and corresponding histogram parameters (including ΔHF, rHF, ΔPVP, rPVP, and AEFvariance) in patients with HCC derived from traditional triphasic CT scans may be helpful to non-invasively and pre-operatively predict the degree of the differentiation of HCC.

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