简介:Biologicalelementsusuallyexerttheirfunctionsthroughinteractionswithotherstoformvarioustypesofbiologicalnetworks.Theabilityofcontrollingthedynamicsofbiologicalnetworksisofenormousbenefitstopharmaceuticalandmedicalindustryaswellasscientificresearch.Thoughtherearemanymathematicalmethodsforsteeringdynamicsystemstowardsdesiredstates,themethodsareusuallynotfeasibleforapplyingtocomplexbiologicalnetworks.Thedifficultiescomefromthelackofaccuratemodelthatcancapturethedynamicsofinteractionsbetweenbiologicalelementsandthefactthatmanymathematicalmethodsarecomputationallyintractableforlarge-scalenetworks.Recently,aconceptincontroltheory--controllability,hasbeenappliedtoinvestigatethedynamicsofcomplexnetworks.Inthisarticle,recentadvancesonthecontrollabilityofcomplexnetworksandapplicationstobiologicalnetworksarereviewed.Developingdynamicmodelsisthepriorconcernforanalyzingdynamicsofbiologicalnetworks.First,weintroduceawidelyuseddynamicmodelforinvestigatingcontrollabilityofcomplexnetworks.Thenrecentstudiesoftheoremsandalgorithmsforhavingcomplexbiologicalnetworkscontrollableingeneralorspecificapplicationscenariosarereviewed.Finally,applicationstorealbiologicalnetworksmanifestthatinvestigatingthecontrollabilityofbiologicalnetworkscanshedlightsonmanycriticalphysiologicalormedicalproblems,suchasrevealingbiologicalmechanismsandidentifyingdrugtargets,fromasystematicperspective.
简介:WiththearchitecturalhistoryupontheQinghai-TibetPlateauspanningbackfourtofivethousandyears,theTibetanarchitecturehasgivenrisetothreebasicforms:palaces,monasteriesandcivilianresidences.
简介:Next-generationsequencing(NGS)isanewtechnologyusedforDNAandRNAsequencingandvariant/mutationdetection.NGScansequencehundredsandthousandsofgenesorwholegenomeinashortperiodoftime.Thesequencevariants/mutationsdetectedbyNGShavebeenwidelyusedfordiseasediagnosis,prognosis,therapeuticdecision,andfollowupofpatients.Thecapacityofitsmassiveparallelsequencingoffersnewopportunitiesforpersonalizedprecisionmedicine.
简介:摘要目的回顾性分析儿童麻疹特点并探讨治疗措施。方法选择我院2016年1月至2019年3月收治的90例儿童麻疹患儿作为研究对象,回顾性分析麻疹患儿的地区分布、年龄分布、疫苗接种情况、临床表现、并发症、临床治疗措施和疾病愈后,总结目前儿童麻疹的发病特点及治疗措施。结果90例麻疹患儿有32例发病前未曾明确接种过麻疹疫苗,56例发病前接种过1次疫苗,2例发病前接种2次疫苗。8月龄以下患儿23例。患儿临床表现主要为皮疹、发热、Koplik斑、畏光流泪、口腔黏膜粗糙等,20例患儿出现类百日咳样咳嗽。并发症以支气管肺炎、心肌损害、支气管炎为主。59例患儿使用抗生素,前3位为青霉素、头孢他啶、美洛西林-舒巴坦钠;27例使用抗病毒药物利巴韦林;2例使用丙种球蛋白注射液;84例使用中药制剂,前3位为口服莲花清瘟胶囊、蒲地兰口服液、小儿豉翘清热颗粒。临床痊愈出院69例、21例好转出院,无患儿死亡。结论8月龄以下婴儿及单次接种疫苗儿童成为麻疹的新兴高发人群,临床表现仍以典型症状为主,抗生素治疗普遍应用于麻疹合并肺部感染的治疗,患儿中成药使用以清热解毒药物为主。
简介:Inordertoimprovethecompressivestrengthofxonotlite,thepretreatedquartzpowder,slakedCaO,additive,deionizedwater(water-solidratioof30)wereplacedinamagneticallystirredautoclave,andthecorrespondingproductswereobtainedafterincubatingat220℃for0,1,3and6h,respectivelytoexplorethesyntheticprocessofxonotlite.Inthepreparedxonotlitepowder,0,5%,10%,15%and20%(bymass,thesamehereinafter)ofpre-treatedceramicstaplefiberswereadded,andtwosetsofspecimenwiththespecificationsofφ50mm×35mmweremoldedbypressedfiltration.Onesetofspecimenswerenotsintered,andtheothergroupwasfiredat1000℃for2htoexploretheeffectofceramicfiberadditiononthecompressivestrengthbeforeandaftersinteringofxonotlite.TheresultsshowthatC-S-Hgelisfirstsynthesizedinthesynthesisofxonotlite,andthentheC-S-Hgelistransformedtoformtobermlite,atlasttobermlitefullyreactstoproducexonotlite.Theadditionofceramicfiberenhancesthecompressivestrengthofthexonotlitebeforeandaftersintering.Whenthe15%ceramicfiberisadded,thecompressivestrengthisthehighest.Thespecimensbeforeandafterthehightemperaturefiringcontainxonotlitephaseandcalciumsilicatephase,respectively,andthecompressivestrengthofthefiredspecimensishigherthanthatofthegreenones.
简介:Aneuralnetwork(NN)isapowerfultoolforapproximatingboundedcontinuousfunctionsinmachinelearning.TheNNprovidesaframeworkfornumericallysolvingordinarydifferentialequations(ODEs)andpartialdifferentialequations(PDEs)combinedwiththeautomaticdifferentiation(AD)technique.Inthiswork,weexploretheuseofNNforthefunctionapproximationandproposeauniversalsolverforODEsandPDEs.ThesolveristestedforinitialvalueproblemsandboundaryvalueproblemsofODEs,andtheresultsexhibithighaccuracyfornotonlytheunknownfunctionsbutalsotheirderivatives.ThesamestrategycanbeusedtoconstructaPDEsolverbasedoncollocationpointsinsteadofamesh,whichistestedwiththeBurgersequationandtheheatequation(i.e.,theLaplaceequation).
简介:ItisdifficulttodesignaplatewithwideattenuationzonesinlowfrequencyregionbasedonBraggscatteringmechanism.Aplatewithperiodicrhombusholesisoptimizedanddesigned.Basedonthefiniteelementmethodunderperiodicboundaryconditions,thein-planedispersioncurvesofperiodicallyperforatedplatearecalculatedviaCOMSOL.ThefrequencyresponsesofperiodicallyperforatedplateareinvestigatedviaANSYSsimulation.Theplateswithperiodicholesaresuspendedanddynamicallytestedundersinusoidalexcitations.Theresultsshowthataperiodicallyperforatedplatewithrhombusholeshaswiderattenuationzonesthanplateswithcircularandhexagonalholes.Materialpropertieshaveagreatinfluenceonattenuationzones:nitrile-butadienerubberandsiliconrubbercaneasilyobtainlow-frequencyzones,whileincreasingporositycreateslowerandwiderzones.Thewidthofattenuationzoneincreasesasthehorizontalangleoftherhombusholesincreases.Ananalysisoftheattenuationzones'generationmechanismshowsthattheplatewithperiodicholesexhibitscharacteristicsofBraggscatteringandlocalresonantphononiccrystal,indicatinganinherentrelationshipbetweentwotypesofmechanisms.Theoptimizedplatehasacompleteattenuationzonerangingfrom5281.76-8824.30Hz.Thevibrationsaresignificantlyreducedwhenthenumberofperiodsisnolessthantwo.Theattenuationrangeobtainedviathenumericalmethodisgenerallyconsistentwiththeexperiment.Theresearchshedslightonthenoiseinsulationplateandhasthepotentialtoimprovethesoundenvironmentinvariousapplicationsduetoitssimplemanufacturing.
简介:摘要:目的 :探讨 90例小儿支原体肺炎的护理体会。方法 :本组资料 90例,均为本院的住院患儿,男 47例,女 43例,年龄 3个月~ 12岁,平均年龄 5岁。干预组 45例,男 30例,女 15例 ;对照组 45例,男 27例,女 18例。所有患儿皆符合《实用儿科学》中关于肺炎支原体肺炎相关的诊断标准。 40例患儿均存在呼吸困难、体温过高、咽喉疼痛、咳嗽等相关的临床症状,通过肺部听诊,显示呼吸音粗,同时存在湿啰音或者喘鸣音,胸片证实为支气管肺炎两组患儿在年龄、性别、生命体征、治疗方法以及临床症状等各方面比较差异无统计学意义 (P>0.05),具有可比性。结果:在实施不同临床护理干预后咳嗽缓解时间、体温恢复时间两项临床指标进行比较,干预组效果明显优于对照组,差异具有统计学意义 (P< 0.05);干预组总有效率达到 94.78%,对照组总有效率达到 70.89%;两组患儿总有效率间和家长满意度间比较,干预组明显高于对照组,差异具有统计学意义 (P< 0.05)。结论 :对支原体肺炎患儿,采取有针对性的护理措施,对提高临床治疗效果和康复程度具有重要意义。
简介:摘要 :目的 :探讨分析常规药物治疗的同时给予氯吡格雷治疗在心绞痛患者中的应用效果。方法 :选取本院 2017年 9月 -2018年 9月期间收治的心绞痛患者 90例 ,按照治疗方式的不同将其分为观察组和对照组 ,每组 45例。对照组采取依那普利与阿司匹林的常规药物治疗措施 ,观察组采取常规药物治疗的同时给予氯吡格雷治疗措施。结果 :观察组 45例中 ,对于常规药物治疗的同时给予氯吡格雷治疗后的效果 ,无效 1例 ,有效 44例 ,临床治疗有效率 97.8%;对照组 45例中 ,无效 5例 ,有效 40例 ,临床治疗有效率 88.9%。观察组治疗有效率显著高于对照组 ,且差异较大 ,存在统计学意义 (P<0.05)。结论 :将常规药物治疗的同时给予氯吡格雷治疗模式运用于心绞痛患者工作中 , 充分满足患者生理和心理上的需求
简介:摘要目的探讨90例小儿支原体肺炎的护理体会。方法本组资料90例,均为本院的住院患儿,男47例,女43例,年龄3个月~12岁,平均年龄5岁。干预组45例,男30例,女15例;对照组45例,男27例,女18例。所有患儿皆符合《实用儿科学》中关于肺炎支原体肺炎相关的诊断标准。40例患儿均存在呼吸困难、体温过高、咽喉疼痛、咳嗽等相关的临床症状,通过肺部听诊,显示呼吸音粗,同时存在湿啰音或者喘鸣音,胸片证实为支气管肺炎两组患儿在年龄、性别、生命体征、治疗方法以及临床症状等各方面比较差异无统计学意义(P>0.05),具有可比性。结果在实施不同临床护理干预后咳嗽缓解时间、体温恢复时间两项临床指标进行比较,干预组效果明显优于对照组,差异具有统计学意义(P<0.05);干预组总有效率达到94.78%,对照组总有效率达到70.89%;两组患儿总有效率间和家长满意度间比较,干预组明显高于对照组,差异具有统计学意义(P<0.05)。结论对支原体肺炎患儿,采取有针对性的护理措施,对提高临床治疗效果和康复程度具有重要意义。
简介:摘要目的探讨分析常规药物治疗的同时给予氯吡格雷治疗在心绞痛患者中的应用效果。方法选取本院2017年9月-2018年9月期间收治的心绞痛患者90例,按照治疗方式的不同将其分为观察组和对照组,每组45例。对照组采取依那普利与阿司匹林的常规药物治疗措施,观察组采取常规药物治疗的同时给予氯吡格雷治疗措施。结果观察组45例中,对于常规药物治疗的同时给予氯吡格雷治疗后的效果,无效1例,有效44例,临床治疗有效率97.8%;对照组45例中,无效5例,有效40例,临床治疗有效率88.9%。观察组治疗有效率显著高于对照组,且差异较大,存在统计学意义(P<0.05)。结论将常规药物治疗的同时给予氯吡格雷治疗模式运用于心绞痛患者工作中,充分满足患者生理和心理上的需求,有助于提高疗效,可帮助患者治疗及恢复,对临床症状和预后的改善具有良好的促进作用,效果显著,治疗满意度高,值得临床推广与运用。
简介:Aseriesofsolarradiationtestsforthepolytetrafluoroethylene(PTFE)bulkandfilmsampleswerecarriedoutusingQ-SUNXE-3-HSCtypeSolarRadiationSimulator,withthetestparametersasfollows:radiationintensityis1120W/m~2,temperatureis55℃andhumidityis70%RH.Surfacemorphology,compositionandmicrostructureofthePTFEsamplesbeforeandafterradiationtestswerecharacterizedcontrastively.EffectofsolarradiationonthetribologyandwettingpropertiesofPTFEwerealsostudiedbytribometerandcontactangletester,respectively.Theresultsshowthat,forradiatedPTFE,surfaceroughness,therelativecontentofCelement,thefrictioncoefficientsandthecontactanglewithwaterincreasedinvaryingdegrees.Inconclusion,theobviouschangeinPTFEsamplescanbemainlyattributedtobreakof(CFx)-CbondsafterbombardmentofhighenergyUVphotons,whichcausesthelossofF-richgroups,oxidation,crosslinkingandrestructuringofactiveunsaturatedgroups.
简介:ThePayangazucomplexinthecentralMyanmariscomposedmainlyofquartzdiorite,granodiorite,andsomesynplutonicmaficdikes.ThequartzdioriteandgranodioritehavezirconU-Pbagesof130.5±4.0(MSWD=3.5)and118.4±2.5Ma(MSWD=2.4),respectively.Rocksamplesofthequartzdioriteandgranodioritearemetaluminous,enrichedinlarge-ionlithophileelementslikeLREE,Rb,Th,andU,anddepletedinhighfield-strengthelementssuchasHREE,Nb,Ta,P,andTi,indicativeofarc-typemagmaticaffinities.WholerocksamplesofthequartzdioritehaveεHf(t)valueof+0.6,initial^87Sr/^86Srratiosof0.7086to0.7100,andεNd(t)valuesof-4.8to-4.9;whereasrocksofthegranodioritearerelativelyisotopicallyenriched,withεHf(t)valuesof-5.1to-7.2,initial^87Sr/^86Srratiosof0.7117to0.7118,andεNd(t)valuesof-8.7to-8.8.TheisotopicdatatogetherwiththehighMg#(boththequartzdioriteandgranodioritehaveMg#valuesof>40)suggestastronginvolvementofmantlematerialsinthegenesisoftheparentmagmas.Thepossiblepetrogeneticprocessmaybethattheascendingofmeltsfrompartialmeltingofmetasomatizedmantlewedgetriggeredbydehydrationofsubductedslabresultedinpartialmeltingofthelowercrustandmixedwiththelatter.TheseEarlyCretaceousintrusionsfromthecomplexareolderthanthosefoundintheeasternWuntho-PopaarcinwesternMyanmar,easternHimalaya,andwesternYunnanwhichareinterpretedtoberelatedtotheNeo-Tethyansubduction,andhaveεNd(t),εHf(t)valueslowerthanthelatter.Onthecontrary,theagesandgeochemicalcharacteristicsofthePayangazucomplexareconsistentwithsomeoftheintrusionsinthenorthernmagmaticbeltinTibet,easternHimalaya,andwesternYunnanwhicharebelievedtobeassociatedwiththesubductionoftheBangong-NujiangOceancrust.Thus,weproposethattheEarlyCretaceousintrusionsinthecentralMyanmararemostlikelyrelatedtothesouthwardsubductionofanoceanslabthatwaspossiblyanextensionoftheBangong-NujiangOcean.