简介：Pulsediagnosisisaspecialmethodofdiagnosingpatient’sdisease.Amathematicalmodelofthepulseispresentedinthispaper.Thefeatureparametersofthesphygmogramareextractedbasedonthesignalmodel.Thediscriminationandprincipalanalysisareemployedtoidentifythepulses.Theresultsarematchingwiththoseoftraditionalmethods.

简介：Theresultsofautomaticclassificationoftheperipheralbloodleukocytecategoriesarepresented.Thisclassificationwasperformedbymeansofdigitalimageprocessingandpatternrecognitiontechniques.Inthispaper,anautomaticmicroscopecellularanalysissystemforthispurposeisgivenandasetofalgorithmsforleukocyterecognitions,whichincludesindividualcell’sdetection,scenesegmentation,featureextraction,selectionandclassifierdesign,isproposed.Asaresultofteston3000leukoeytesdigitizeddirectlyfrom21peripheralbloodsmears,92percentofthemwereclassifiedcorrectlyinthissystem.Thecategorieswerebandneutrophils,seg-mentedneutrophils,monocytes,eosinophils,basophilsandlyrnphoeytes.

简介：非职业暴露后预防（nPEP）是指包括对性暴露后与静脉药物注射暴露后的预防HIV感染的措施，应该尽可能早的开始（暴露后72h内），用多种药物联合治疗连续28d，nPEP中心理咨询也是重要的组成部分，抗逆转录病毒治疗首选2个核苷类逆转录酶抑制剂，相对于职业暴露来说nPEP在预防HIV感染方面没有很好的效果，容易失败的原因主要有：①延时治疗；②非职业暴露者对PEP治疗依从性差；③反复多次发生暴露；④进行肛交是预防HIV感染所面临的一个严峻的问题；⑤不合理的药物组合。

简介：利用系统生物学原理和计算机理论,研究HIV的结构和生命周期。扩展通用图灵机模型是一种计算机模型,使用这种模型描述HIV的结构和生命周期,能够将计算机与HIV结合起来,将生物化学反应过程转化为计算机运算模拟过程,从而简化了生物化学实验,减短实验周期。基于扩展通用图灵机的HIV描述不仅能够反映HIV的结构和生命周期,而且更加突出了HIV的感染特性。

简介：5氟尿嘧啶(5-FU)举办许多反肿瘤活动，广泛地适用于癌症的治疗。然而，由于它的狭窄的治疗学的索引在临床的实践决定5-FU的血浆集中是必要的。因此，一个简单、经济、敏感的高效的液体层析(HPLC)方法在人的血浆为5-FU的决心被开发并且验证。乙醇醋酸盐被选择为抽取试剂。色析法的分离在DiamonsilC18列上被执行(250公里獲汥?楷桴琠敨愠獤牯瑰潩?慲楴?楷桴畯?敭桴湡汯

简介：BiochaninA(BCA),themostabundantisoflavoneinchickpeas,presentsawiderangeofbiologicalactivities,suchashypolipidaemic,anti-oxidative,antiproliferative,andestrogen-likeeffects.WeinvestigatedtheinteractionbetweenBCAandhumanserumalbumin(HSA)viaseveraltechniques.UV–VisabsorptionspectroscopyverifiedtheconformationalvariationofHSAafterBCAaddition,andfluorescencespectroscopyrevealedtherelevantbindingparameters.CirculardichroismspectroscopywasusedtoestimatethesecondarystructuralchangesofHSAwithandwithoutBCA.MoleculardockinganddynamicssimulationswerethenappliedtostudythecharacteristicsofHSAwithBCA.EnergydecompositionanalysiswasusedtoprovethatTrp214insubdomainIIAofHSAisthemostlikelybindingsiteofBCA.VanderWaalsforcesandhydrophobicinteractionsmayplayimportantrolesduringthebindingprocess.AllofourresultsshowedthatBCApresentssignificantbindingaffinitytoHSA,thusconfirmingthattheroleofHSAhasasanefficienttransporterofbiomolecules.