简介：摘要：针对某军用电子设备CE102测试时线缆产生的空间辐射会因为产品线缆的敷设方式不同使CE102的测试结果产生影响，本文通过信号源模拟空间辐射，结合《军用设备和分系统电磁发射和敏感度要求与测量》（GJB 151B-2013）中的测试方法，探究了空间辐射对CE102的主要影响频点，为电磁兼容实验室以后进行CE102项目整改时提供参考思路。

简介：摘要：座舱增压控制系统是飞机在高空运行的关键系统，本文通过分析CE52 CJ1飞机和M2飞机的座舱增压原理和具体实现过程，比较研究了两者的异同。根据CE52 CJ1飞机的典型故障，对M2型飞机座舱增压系统的维护做出了提示。

简介：摘要：CE525CJ1飞机使用与冲压空气进行热交换后的发动机引气来对座舱进行增压。本文以CE525CJ1飞机增压系统为研究对象，对增压系统的工作原理进行总结，对增压系统典型故障予以分析，以期为行业维护人员了解增压系统，有效预测故障，高效排除故障提供参考借鉴。

简介：摘要：IV建筑气候区长夏无冻，温度高湿气重，气温年均差和日均差均小；雨量丰沛，夏季多热带风暴和台风袭击，易有大风暴雨天气，受外界因素的多重影响容易导致建筑外墙饰面砖脱落、空鼓等质量事故的发生。本文结合泉州海上海项目实际情况，根据外墙马赛克施工工艺，对影响外墙马赛克黏结强度的不同基体、不同基层抹灰厚度、基层抹灰次数三个因素，并结合现场实际工艺参数进行正交试验。结合实验结果经计算分析，得出影响外墙马赛克强度的最主要因素是抹灰厚度，在项目施工过程中应注意对基层抹灰厚度的控制，确保施工质量处于可控状态。

简介：AbstractBackground:Disease activity indices (DAIs) including disease activity score 28 (DAS28), simplified disease activity index (SDAI), and clinical disease activity index (CDAI) have been widely used in clinical practice and research studies of rheumatoid arthritis (RA). The objective of our study was to evaluate the correlation and concordance among different DAIs in Chinese patients with RA.Methods:A cross-sectional study, including patients enrolled in the Chinese registry of rheumatoid arthritis from November 2016 to August 2018, was conducted. The correlations were evaluated using Spearman correlation coefficient and concordance with Bland-Altman plots, quadratic weighted kappa, and discordance rates in the crosstab. For other indices, the optimal cutoff points corresponding to SDAI remission were explored through receiver operating characteristic curve analysis.Results:A total of 30,501 patients were included, of whom 80.46% were women. Most individuals were with moderate disease activity or high disease activity. High correlations among DAS28-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP), SDAI and CDAI were observed. Similarly, the weighted kappa value among the indices was high. In Bland-Altman plots, a positive difference between DAS28-ESR and DAS28-CRP was observed, with an absolute difference of >1.2 in 3079 (10.09%) patients. In crosstab, approximately 30% of the patients were classified into different groups. Concordance values between SDAI remission and the optimal cutoff points of DAS28-ESR, DAS28-CRP, and CDAI were 3.06, 2.37, and 3.20, respectively.Conclusions:Although DAIs had high correlations and weighted kappa values, the discordance between DAIs was significant in Chinese patients with RA. The four DAIs are not interchangeable.

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简介：【摘要】目的：探讨分析利福平治疗鼻咽癌Ⅲ.IV度放射性皮炎的观察与护理效果。方法：从近两年于我院收治的鼻咽癌Ⅲ.IV度放射性皮炎患者病例中，选取100例作为研究对象，根据随机数字表法，分为观察组和对照组，各为50例，分别采取利福平外敷、金因肽喷雾，将临床总有效率作为两组研究对象的评价指标。结果：在治疗效果的对比方面，对照组患者50例中总体有效的例数为43例，总有效率86.00%，比观察组患者50例中有49例患者有效的980.00%低，对比差异明显（P＜0.05）。结论：在鼻咽癌Ⅲ.IV度放射性皮炎治疗方面，利福平治疗的应用价值不可小觑，可以确保治疗效果的稳步提升，将创面愈合进度提升上来。

简介：AbstractBackground:Although de novo stage IV breast cancer is so far incurable, it has entered an era of individualized treatment and chronic disease management. Based on systemic treatment, whether the surgical resection of primary or metastatic foci of de novo stage IV breast cancer can bring survival benefits is currently controversial. We aimed to explore the clinicopathological factors and current status of the management of de novo stage IV breast cancer in China to provide a reference for clinical decisions.Methods:Based on the assistance of Chinese Society of Breast Surgery, a retrospective study was conducted to analyze the clinical data of patients with de novo stage IV breast cancer in 33 centers from January 2017 to December 2018. The relationship between basic characteristic (age, menstrual status, family history, reproductive history, pathological type, estrogen receptor [ER] status, progesterone receptor [PR] status, human epidermal growth factor receptor 2 [HER2] status, Ki-67 percentage, and molecular subtype), and metastasis sites (lung metastasis, liver metastasis, and bone metastasis) was examined by Pearson Chi-square tests.Results:A total of 468 patients with de novo stage IV breast cancer were enrolled. The median age of the enrolled patients was 51.5 years. The most common pathological type of primary lesion was invasive carcinoma (97.1%). Luminal A, luminal B, HER2 overexpressing, and triple-negative subtypes accounted for 14.3%, 51.8%, 22.1%, and 11.8% of all cases, respectively. Age, PR status, and HER2 status were correlated with lung metastasis (χ2= 6.576, 4.117, and 8.643 and P = 0.037, 0.043, and 0.003, respectively). Pathological type, ER status, PR status, and molecular subtype were correlated with bone metastasis (χ2 = 5.117, 37.511, 5.224, and 11.603 and P = 0.024, <0.001, 0.022, and 0.009, respectively). Age, PR status, HER2 status, Ki-67 percentage, and molecular subtype were correlated with liver metastasis (χ2= 11.153, 13.378, 10.692, 21.206, and 17.684 and P= 0.004, <0.001, 0.001, <0.001, and 0.001, respectively). Combined treatment with paclitaxel and anthracycline was the most common first-line chemotherapy regimen for patients with de novo stage IV breast cancer (51.7%). Overall, 91.5% of patients used paclitaxel-containing regimens. Moreover, 59.3% of hormone receptor-positive patients underwent endocrine therapy.Conclusions:In 2018, 1.07% of patients from all studied centers were diagnosed with de novo stage IV breast cancer. This study indicated that 95.1% of patients received systemic therapy and 54.2% of patients underwent surgical removal of the primary lesion in China.

简介：摘要：本文通过采用Cu-Cr-Ni-M-V合金元素成分设计了耐海水腐蚀螺纹钢HRB500cE小方坯的化学成分，连铸拉速控制、温度制度和冷却制度等工艺手段，成功开发了符合国标的耐海水腐蚀螺纹钢HRB500cE小方坯。结果表明，连铸小方坯表面质量和低倍组织质量均合格，说明制备工艺可以大规模生产。

简介：摘要目的探讨应用肌皮瓣联合负载抗生素聚甲基丙烯酸甲酯（PMMA）骨水泥来治疗Cierny-Mader III~IV型骨髓炎的临床效果。方法2014年4月至2019年3月,对53例Cierny-Mader III~IV型慢性骨髓炎患者,应用负载抗生素PMMA骨水泥联合肌皮瓣技术进行修复。其中男33例,女20例,年龄52.2±3.0（29~78）岁。53例骨髓炎病灶创面大小为2.0 cm×2.0 cm~14.0 cm×28.0 cm。皮瓣供区均直接缝合。术后3个月取出骨水泥23例,未取出骨水泥30例。术后观察皮瓣血运、创面渗液、供区并发症、X线复查有无新鲜骨破坏征象及皮瓣的色泽、质地、瘢痕等情况。门诊定期随访。结果49例创口一期愈合,4例创口延期愈合。术后发生血管危象6例,及时手术探查后缓解。术后随访0.6~3.0年,平均为18个月。53例肌皮瓣全部成活,色泽与受区相似,皮瓣平整,质地柔软,外形满意。随访期间X线复查无新鲜骨破坏征象,局部骨髓炎征象明显控制。皮瓣均未出现红肿、疼痛、局部破溃、渗液等炎症反应,无骨髓炎复发。所有供瓣区一期愈合。结论肌皮瓣联合负载抗生素PMMA骨水泥治疗Cierny-Mader III~IV型骨髓炎,抗感染效果好,疗效满意,术后并发症少,复发率低,值得临床推广应用。

简介：【摘要】目的：分析阿糖胞苷联合化疗后致IV度骨髓抑制白血病患者的护理效果。方法：选取我院2020年2月到2021年2月就诊的阿糖胞苷联合化疗后致IV度骨髓抑制白血病患者50例作为研究样本，针对这些患者选取针对性护理干预措施，分析其护理效果。结果：50例患者，通过护理干预之后，平稳度过骨髓抑制期的患者有48例，有效率为96.00%（48/50）。结论：有效的护理干预，可帮助患者度过骨髓抑制期，确保化疗质量，能明显提升护理质量，具备推广和使用价值。

简介：摘 要：随着我国汽车工业的快速健康发展，汽车噪声污染问题越来越突出，相应的汽车环境噪声管理法规也对各类汽车噪声控制要求越来越严格。发动机缸和排气管的噪声是目前汽车的主要噪声源，本文对国IV发动机的商用车排气系统进行分析，探究其低噪声设计及应用。

简介：摘要：目的 分析在IV期肺腺癌患者治疗中阿帕替尼联合化疗对比单纯化疗的效果。方法 选入患者50例，为本院在2019年2月至2020年1月所接诊，通过随机筛选的方式，取25例患者作为观察组,给予阿帕替尼联合化疗。其余25例作为对照组,给予常规化疗，分析患者的总生存期及不良反应。结果 结合对两组患者的预后总生存期以及治疗中不良反应情况等对比，观察组均存在优势，P

简介：摘要：2020年上半年，为贯彻落实教育部疫情防控期间“停课不停教、停课不停学”的要求，全国高校都经历了史无前例的全面在线教学。以黑龙江大学俄语专业《俄语实践（IV）》在线教学为例，总结了在线教学设计、在线教学实施与成效和在线教学特色，并对其进行了深入的反思。希望能对后疫情时期的线下教学或线上线下混合教学具有一定的启示性作用。

简介：【摘要】目的 研讨护理干预持续质量改进在改善心功能III-IV级患者容量管理中的价值。方法 选择90例心功能III-IV级患者，均来源于本院2019年12月-2020年5月期间收入，按住院顺序随机分成两组，常规组和观察组，组内分别有45例。常规组实施常规护理，观察组实施护理干预持续质量改进，对比两组心功能指标、患者依从性和再入院间隔时间。结果 两组护理前左室射血分数（LVEF）、左室收缩末内径（LVESD）、左室舒张末内径（LVEDD）、6分钟步行距离（6MWT）值相比较无差异（P＞0.05），护理后观察组LVESD和LVEDD明显低于常规组，LVEF高于常规组，6MWT长于常规组（P＜0.05）；观察组再入院间隔时间长于常规组（P＜0.05）；观察组依从性为95.56，高于常规组的77.78%（

简介：[摘要] 总结1例直乙交界癌合并糖尿病患者NOSESIV术后并发蜂窝织炎的护理方法。 其护理要点包括：右下腹壁蜂窝织炎的治疗和护理，糖尿病的治疗和护理，营养支持，术后常规护理及心理护理。本例患者住院25天，经过有效的诊治和精心的护理蜂窝织炎治愈，康复出院。

简介：摘要目的探讨非典型CE1型肝囊型包虫病的有效诊断方法及腹腔镜手术的临床疗效。方法回顾性分析2018年6月至2019年6月新疆维吾尔自治区人民医院收治的17例非典型CE1型肝囊型包虫患者临床资料，其中男性11例，女性6例，年龄(46.0±21.6)岁，均有畜牧区接触史。术前完善包虫免疫实验、腹部超声、腹部CT检查，行腹腔镜手术治疗，术后采用门诊复查、电话等方式进行随访，随访时间截至2020年6月。对术前不同检查方法诊断情况、手术方式、包虫病复发等指标进行分析。结果17例患者术前肝包虫病血清免疫学检查11例为囊性包虫病阳性，6例阴性。腹部CT诊断结果示17例均为肝囊肿。常规彩色多普勒超声示14例患者为肝囊肿，3例示肝囊性占位，囊型包虫病不除外；更换高频探头后9例患者观察到肝囊性病灶顶部节段双轨征或局部增厚囊壁，诊断为CE1型肝囊型包虫病，8例仍诊断为肝囊肿。17例患者均行腹腔镜手术，术中均明确诊断为肝囊型包虫病，无中转开腹，手术时间(125.0±54.5)min；术中出血量为(150.0±84.5)ml，术后住院时间为(6.5±2.5)d；围手术期无严重并发症或死亡病例，2例术后出现微胆漏，术后5～10 d自行痊愈；术后随访6～12个月，无失访，未见肝脏及腹腔包虫复发。结论在肝脏单囊型病灶的诊治过程中应注意非典型CE1型肝囊型包虫与单纯性肝囊肿的鉴别诊断，腹部螺旋CT、包虫免疫实验、腹部超声有效鉴别率低，易误诊、漏诊，腹部超声高频探头可一定程度提高非典型CE1型肝囊型包虫诊断率。腹腔镜技术既是有效诊断方法也是治疗手段，需根据患者包虫病灶情况选择合理手术方式，腹腔镜手术治疗肝囊型包虫病安全、可行。

简介：AbstractBackground:The Shexiang Baoxin Pill (MUSKARDIA) has been used for treating coronary artery disease (CAD) and angina for more than 30 years in China. Nevertheless, methodologically sound trials on the use of MUSKARDIA in CAD patients are scarce. The aim of the study is to determine the effects of MUSKARDIA as an add-on to optimal medical therapy (OMT) in patients with stable CAD.Methods:A total of 2674 participants with stable CAD from 97 hospitals in China were randomized 1:1 to a MUSKARDIA or placebo group for 24 months. Both groups received OMT according to local tertiary hospital protocols. The primary outcome was the occurrence of a major adverse cardiovascular event (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction (MI), or non-fatal stroke. Secondary outcomes included all-cause mortality, non-fatal MI, non-fatal stroke, hospitalization for unstable angina or heart failure, peripheral revascularization, angina stability and angina frequency.Results:In all, 99.7% of the patients were treated with aspirin and 93.0% with statin. After 2 years of treatment, the occurrence of MACEs was reduced by 26.9% in the MUSKARDIA group (MUSKARDIA: 1.9% vs. placebo: 2.6%; odds ratio = 0.80; 95% confidence interval: 0.45-1.07; P = 0.2869). Angina frequency was significantly reduced in the MUSKARDIA group at 18 months (P = 0.0362). Other secondary endpoints were similar between the two groups. The rates of adverse events were also similar between the two groups (MUSKARDIA: 17.7% vs. placebo: 17.4%, P = 0.8785).Conclusions:As an add-on to OMT, MUSKARDIA is safe and significantly reduces angina frequency in patients with stable CAD. Moreover, the use of MUSKARDIA is associated with a trend toward reduced MACEs in patients with stable CAD. The results suggest that MUSKARDIA can be used to manage patients with CAD.Trial registration:chictr.org.cn, No. ChiCTR-TRC-12003513

简介：摘要磷脂酶CE1(PLCE1)是磷脂酶家族中一类特殊的磷脂酶C同工酶，表达于成熟肾小球的足细胞，通过多种方式参与细胞的信号转导，从而促进其生长发育及表达。PLCE1的单基因突变、与其他致病基因的杂合突变、该酶与其他因子的相互作用均有可能导致儿童原发性肾病综合征(PNS)。目前已有因PLCE1突变引起的激素耐药型肾病综合征患儿服用钙调蛋白抑制剂后痊愈的案例，为治疗此类疾病带来了新的治疗方案。现主要就PLCE1的表达、生物学功能、导致儿童PNS的机制及对该病的治疗作一综述。

简介：摘要：氨基甲酸酯类农药是一类从氨基甲酸衍生出来的商业化农药，由于使用范围广，使用量巨大，在水中溶解性较强，毒性大，不容易降解，对水生生态系统和人类的健康造成了很大的危害。本文通过合成一种具有锐钛矿晶体结构的介孔材料Ce-MTiO2光催化降解几种商业化的氨基甲酸酯类农药来研究该催化剂在这类农药污染废水治理方面的作用并讨论了光照时间、农药浓度、催化剂用量和溶液体系pH值对光催化降解效率的影响。研究结果表明，该催化剂在紫外光照射下具有很好的催化活性，能将西维因、残杀威、灭多威和克百威这四种氨基甲酸酯农药快速降解，且在碱性条件下，这几种农药的降解率都是最高的，当溶液体系