简介：Nasopharyngealcarcinoma(NPC)isacommonheadandneckmalignancy.TheincidenceofNPCishigherinSouthernChinaandSoutheastAsiacomparedwithWesterncountries.Givenitshighradiosensitivity,thestandardtreatmentforNPCisradiotherapy.However,radioresistanceremainsaseriousobstacletosuccessfultreatment.Radioresistancecancauselocalrecurrenceanddistantmetastasesinsomepatientsaftertreatmentbyradiation.Thus,specialemphasishasbeengiventothediscoveryofeffectiveradiosensitizers.Thisreviewaimstodiscussthebiomarkers,classifiedaccordingtothemainmechanismsofradiosensitization,whichcanenhancethesensitivityofNPCcellstoionizingradiation.

简介：BackgroundHypertensionassociatedwithhyperhomocysteinemia(HHcy)isdefinedasH-typehypertension.HypertensionandHHcyhasastrongsynergythatcouldleadtotheriskofvasculardisease,suchascarotidremodeling.However,therelationofinflammatoryfactorsandadhesionmoleculewithcarotidremodelinginH-typehypertensionisunknown.MethodsFifty-sixpatientswithH-typehypertensionand52withouthyperhomocysteinemiahypertensionwereenrolledinthisstudy,with42healthyvolunteersasthecontrolgroup.AllthesubjectsunderwentcolorDopplerultrasoundexaminationofcarotidartery.TheexpressionofICAM-1inperipheralbloodmonocyteswasmeasuredbydirectimmunofluorescencetechniqueincombinationwithflowcytometry.ThelevelsofhighsensitivityC-reactiveprotein(hs-CRP),Monocytechemoattractantprotein-1(MCP-1)andsICAM-1weremeasured.Thecorrelationsbetweencarotidvascularremodelingandthesebiomarkerswereanalyzed.ResultsTheintima-mediathickness(IMT),circulatinglevelsofhs-CRPandMCP-1,andmonocyteICAM-1weresignificantlyincreasedinH-typehypertensiongroup(P<0.05).Therewerenosignificantdifferenceinthosemeasurementsbetweenthesimplehypertensiongroupandthecontrolgroup(P>0.05).ThelevelsofsICAM-1showednosignificanceamongthethreegroups(P>0.05).Correlationanalysesrevealedapositivecorrelationofcarotidplaqueindexwithhomocysteine,hs-CRPandMCP-1,andtheexpressionofICAM-1inthemonocytesintheH-typehypertensiongroup.MultivariatelogisticregressionanalysisrevealedthatHcyandhs-CRPweretheindependentriskfactorsofIMTintheH-typehypertensiongroup.ConclusionThepatientswithH-typehypertensionaremorelikelytohavecarotidvascularremodelingwithhigherlevelsofinflammationandadhesionmoleculeswhichmightleadtothedevelopmentofatherosclerosis.