简介：Introduction:Frequencydoublingtechnology(FDT)providesascreeningprogramforthedetectionofglaucomatousopticnervedamage.Theexaminationtimeusingthisprogramisveryshort,lessthanoneminutepereye.High-passresolutionperime-try(HRP)isknowntobesensitiveforearlyglaucomadamageandhasbeenreportedtodetectchangeearlier,thanconvention-

简介：<正>DearSir,Oculartraumaisatopicofunresolvedcontroversiesandtherearecontinuouscontroversialanddebatablediagnosticandmanagementstrategiesforopen-globeinjuries[1].Amongstmanytypesofoculartrauma,theopenglobeinjuryisthemostseriousduetoitsverypoorvisualprognosisandyoungpopulationofpatientsaremostlyaffected[2].Thetreatmentoutcomemaybeimprovedbypromptdiagnosis,andimmediatesurgicalrepairperformedtohighstandard[3].Amongsttheotherclinicalsignstheintraocularpressure(IOP)isfoundtobeparticularlyreducedandconventionallythisisconsideredasaveryreliableindicatorofoccultglobe

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简介：AIM:TocomprehensivelyevaluatethepotentialassociationofCOL1A1polymorphismswithhighmyopiabyasystematicreviewandMeta-analysis.METHODS:AllassociationstudiesonCOL1A1andhighmyopiareporteduptoJune10,2014inPubMed,Embase,WebofScience,andtheChineseBiomedicalDatabasewereretrieved.Oddsratios(ORs)and95%confidenceintervals(95%CIs)wereanalyzedforsinglenucleotidepolymorphisms(SNPs)usingfixed-andrandom-effectsmodelsaccordingtobetween-studyheterogeneity.PublicationbiasanalyseswereconductedbyEgger’stest.RESULTS:Atotaloffourstudiesfromreportedpaperswereincludedinthisanalysis.TheMeta-analysesforCOL1A1rs2075555,composedof2304highmyopiapatientsand2272controls,failedtodetectanysignificantassociationwithhighmyopia.Atotalof971casesand649controlsweretestedforCOL1A1rs2269336.TheassociationofCOL1A1rs2269336withhighmyopiawasobservedinrecessivemodel(CCvsCG+GG,P=0.03)andinheterozygousmodel(CGvsGG,P=0.04),butnotinothermodels.CONCLUSION:ThisMeta-analysisshowsthatCOL1A1rs2269336(CCvsCG+GG)affectsindividualsusceptibilitytohighmyopia,whereasthereisnoassociationdetectedbetweenSNPsrs2075555andhighmyopia.Giventhelimitedsamplesize,furtherinvestigationsincludingmoreethnicgroupsarerequiredtovalidatetheassociation.

简介：AIMTo在cells.METHODSARPE-19细胞是的网膜的颜料上皮(RPE)上调查高葡萄糖层次和反脉管的endothelial生长因素(VEGF)代理人(bevacizumab，ranibizumab和aflibercept)的效果在不同葡萄糖层次(5.5mmol/L，25mmol/L，和75mmol/L)有教养。房间生存能力被MTT试金与D葡萄糖在处理以后在3d评估。房间迁居能力被创伤愈合试金在3d测量。一个房间死亡察觉工具包被用来在3点估计apoptosis并且14d。房间增长被EdU试金在3d估计。文化媒介在临床上相关的集中与anti-VEGF代理人被对待。实验然后在一个不同葡萄糖level.RESULTSThe生存能力被重复，ARPE-19房间的移植显著地作为与5.5mmol/L葡萄糖相比面对75mmol/L被减少。TUNEL积极的房间的百分比显著地被增加，proliferative潜力与5.5mmol/L葡萄糖相比与75mmol/L被减少。在在25mmol/L和5.5mmol/L葡萄糖之间的结果没有重要差别。面对75mmol/L葡萄糖，与anti-VEGF对待的组显示出减少的房间生存能力和增长并且增加了apoptosis。然而，anti-VEGFgroups.CONCLUSIONHigh葡萄糖水平减少之间没有重要差别RPE房间的生存能力，创伤愈合能力，和增长，当增加apoptosis时。而且，anti-VEGF代理人在高葡萄糖的条件下面防碍RPE房间的生理的功能，在房间生存能力和增长由减少伴随了。

简介：AIMTo由高分辨率的Placido基于磁盘的地形学把测量的重覆性/重制度与一个高分辨率的旋转Scheimpflug照相机的作比较并且在与keratoconus在眼睛测量角膜的力量估计在二台仪器之间的协议并且在situkeratomileusis(LASIK)激光以后.METHODSOne眼睛每经历了的36个keratoconic病人和20个题目LASIK在这未来的观察研究被包括。二个独立检查人在一份随机的订单工作了与两台仪器拿每只眼睛的三大小。四个参数在前面的角膜上被测量：陡峭的角膜散光计(K)，扁平的角膜散光计(Kf)，吝啬的角膜散光计(Km)，和散光(Ks-Kf)。Intra检查人重覆性和内部检查人的重制度被计算在内题目标准差(Sw)评估重覆性(R)，变化(CoV)的系数，和intraclass关联系数(国际计算中心)的系数。在仪器之间的同意被计算.RESULTSInkeratoconic眼睛，intra检查人和内部检查人的国际计算中心是的同意(95%LoA)的95%限制与Bland-Altman方法测试>0.95。作为与由高分辨率的Placido基于磁盘的地形学的测量相比，高分辨率的旋转Scheimpflug照相机的intra检查人R是更低的为Kf(0.32对0.88)，K(0.61对0.88)，和Km(0.32对0.84)但是为Ks-Kf(0.70对0.57)更高。内部检查人的R值为用高分辨率的旋转Scheimpflug照相机测量的所有参数是更低的。95%LoA是到为Kf，到为K的+0.99的-1.36，到为Km的+0.50的-1.08，和到为Ks-Kf的+1.48的-1.11的+0.55的-1.28。在post-LASIK眼睛，intra检查人和内部检查人的国际计算中心是>0.87为所有参数。intra检查人和内部检查人的R为用高分辨率的旋转Scheimpflug照相机测量的所有参数是更低的。intra检查人R为Kf是0.17对0.88，0.21对0.88为K，0.17对0.86为Km，并且0.28对0.33为Ks-Kf。内部检查人的R为Kf是0.09对0.64，0.15对0.56为K，0.09对0.59为Km�