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简介：AIM:Toexaminetheintegrityoftheocularsurfacesofsubjectswithandwithoutdiabeteswithnoconjunctivalanddryeyesignsandsymptomsandcompareconjunctivalimpressioncytologyfindingsindiabeticswithnon-proliferativeandproliferativediabeticretinopathy.METHODS:Conjunctivalimpressioncytologywasperformedon43eyesof43subjectswithnonproliferativediabeticretinopathy(NPDR),42eyesof42subjectswithproliferativediabeticretinopathy(PDR),and30eyesof30controlsubjects.Impressioncytologyspecimensofeachgroupweregradedandscoredintherange0-3accordingtoNelson’smethod.RESULTS:Therewere45(52.9%)womenand40(47.1%)men.Themeanageofthepatientswas59.6±9.3y(range,43-76y)inNPDRgroupand58.0±8.8y(range,41-85y)inPDRgroup.CaseswithNPDRandPDRshowedstatisticallysignificanthigherimpressioncytologyscoresthancontrolgroup(P<0.05).TherewasnodifferencebetweentheNPDRandPDRpatientsforimpressioncytologygradingscores.CONCLUSION:ItisdeterminedthatimpressioncytologygradesarealteredinpatientswithNPDRandPDR.Consequently,wesuggestthattheremightbeanassociationbetweentheimpressioncytologygradingscoresandtheseverityofdiabeticretinopathy

简介：AIM:Tocomparetherapeuticeffectsofintravitrealtriamcinoloneacetonide(IVTA)versusintravitrealbevacizumab(IVB)injectionsforbilateraldiffusediabeticmacularedema(DDME).METHODS:Fortyeyesof20patientswithbilateralDDMEparticipatedinthisstudy.Foreachpatient,4mg/0.1mLIVTAwasinjectedtooneeyeand2.5mg/0.1mLIVBwasinjectedtotheothereye.Theeffectsofinjectionfordiabeticmacularedema(DME)wereevaluatedusingbest-correctedvisualacuity(BCVA),centralmacularthickness(CMT)byopticalcoherencetomography(OCT)andintraocularpressure(IOP)byapplanationtonometer.Patientsunderwenteyeexaminations,includingBCVA,CMT,andIOPatpre-injection,1,4,8,12and24wkafterinjection.Duringthefollow-up,secondinjectionswereperformedtoeyeswhichhaveCMTgreaterthan400μmat12wkforsalvagetherapy.RESULTS:BCVA(logarithmoftheminimumangleofresolution)atpre-injection,1,4,8,12and24wkafterinjectionwas0.71±0.19,0.62±0.23,0.63±0.12,0.63±0.13,0.63±0.14and0.61±0.24intheIVTAgroupand0.68±0.25,0.61±0.22,0.60±0.24,0.62±0.25,0.65±0.26and0.59±0.25intheIVBgroup,respectively.CMT(μm)atpre-injection,1,4,8,12and24wkafterinjectionwas544±125,383±96,335±87,323±87,333±92,335±61intheIVTAgroupand514±100,431±86,428±107,442±106,478±112,430±88intheIVBgrouprespectively.ReductionratiosofmeanCMTwere29%at1wk,38%at4wk,40%at8wk,38%at12wk,and38%at24wkintheIVTAgroup.SecondIVTAinjectionswereperformedtothe6eyes(30%)at12wk.ReductionratiosofmeanCMTwere16%at1wk,17%at4wk,14%at8wk,7%at12wk,and16%at24wkintheIVBgroup.SecondIVBinjectionswereperformedtothe15eyes(75%)at12wk.CONCLUSION:Thisstudyshowedearlierandmorefrequentmacularedemarecurrencesintheeyestreatedwithbevacizumabcomparedwiththeonestreatedwithtriamcinoloneacetonide.Triamcinoloneacetonidewasfoundtoprovidemoreefficientandlo

简介：AIMTo在划分的类型2糖尿病的patients.METHODSWe估计在choroidal厚度(CT)和糖尿病的retinopathy(医生)的早阶段之间的关联83个糖尿病的病人(51-80岁；50女性)进非糖尿病的retinopathy，组(NDR)和温和/中等的nonproliferative糖尿病患者retinopathy(NPDR)组织，并且把他们与26个非糖尿病的控制题目作比较(51-78岁；16女性)。Subfovealchoroidal厚度(SFCT)和parafovealchoroidal厚度(PFCT)用提高的深度成像被测量光谱域的光连贯断层摄影术(EDI10月)。眼睛的健康地位，疾病持续时间，身体团索引，和血红素A1c(HbA1c)是NDR，NPDR，和控制组的recorded.RESULTSThe平均数年龄68.0是戠牥晥?景吗？

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简介：AIM:Toidentifyriskfactorsassociatedwithpost-cataractsurgeryendophthalmitis(PCE)intype2diabeticpatients.METHODS:Ahospital-basedretrospectivecase-controlstudywasconductedon194type2diabeticpatientsundergoingcataractsurgeryinRajavithiHospitalfromJanuary2007toDecember2015.FifteenpatientswithPCEwereincludedasthecasegroupand179patientswithoutPCEwereincludedasthecontrolgroup.PotentialfactorsassociatedwithPCEamongbothgroupsincludingdemographics,pre-operativecharacteristics,surgicalsettingsandcomplications,werestatisticallyanalyzedusingChi-squaretestingandalogisticregressionmodel.RESULTS:Withinthecasegroup,53%werefemalesandthemedianagewas68y.Univariateanalysisofpre-operativecharacteristics,surgicalsettingsandcomplicationsrevealedthatrecentpre-operativefastingplasmaglucose,insulintherapy,presenceofdiabeticretinopathy,andseverenon-proliferativeorproliferativediabeticretinopathyweresignificantlyassociatedwithPCE.Inamultivariateanalysisadjustingforbloodglucoselevel,insulintreatmentwastheonlysignificantfactorassociatedwithanincreasedriskofPCE(OR3.9,95%CI1.0-15.0,P=0.04)comparedtopatientswithoutinsulintreatment.Themostcommoncausativeorganismsweregram-positivebacteria(89%).Staphylococcusspeciesrepresentedthemostcommongroup(67%).Medianbestcorrectedvisualacuityat1-monthand3-monthfollow-upwasequalat0.7logMAR(20/100).CONCLUSION:Theauthorsidentifyinsulintreatmentastheonlyriskfactorassociatedwithendophthalmitisaftercataractsurgeryintype2diabeticpatients.Furtherstudieswithserumlevelsofpre-operativeglycatedhemoglobin(HbA1c)andpost-operativefastingplasmaglucoselevelareessentialtotrulydemonstratetheroleofperi-operativeglycemicmarkersasariskfactorforPCE.

简介：AIMTo为Snellen和早治疗糖尿病的Retinopathy学习(ETDRS)图表比较精确性，重制度和测试持续时间，二个主要工具过去常测量视觉尖酸(VA).METHODSA计算机模拟被规划运用多重虚拟病人，有分配参数的一个唯一的集合的各个，包括VA，假积极、假否定的错误珍视。为各个，虚拟耐心的、分配VA随机沿着跨越在1.0～0.0个logMAR单位(到到20/20的20/200的等价物)之间的范围的连续规模被选择。每30000个虚拟病人在每二VAcharts.RESULTSAverage测试持续时间上被运用十次(表示了为在测试±期间介绍的人物的全部的数字；SD)是12.6±；11.1和31.2±；14.7个人物为Snellen和ETDRS，分别地。精确性，定义为绝对差别(±；SD)在分配VA和测量VA之间，在logMAR表示了单位，在ETDRS图表是优异的：0.12±；0.14和0.08±；0.08为Snellen和ETDRS图表，分别地。重制度，表示了可变性为测试网，在ETDRS图表是优异的：0.23±；0.17和0.11±；0.09个logMAR单位为Snellen和ETDRS图表，respectively.CONCLUSIONA比较真(分配)VA到测量VA，平均，更好证明ETDRS的精确性和重制度制图，但是在显著地更长的测试持续时间的惩罚。这些差别最在低VA范围被读。用一条模拟途径的重制度与在几临床的研究发现的重制度价值一致。

简介：AIMTo用光连贯断层摄影术(10月)并且到在奔流外科以后在糖尿病的眼睛估计斑点的量的变化估计开发的发生或有斑点的浮肿变得更坏(我)在糖尿病的眼睛与或没有先存在ME.METHODSIn这未来的、观察研究，经历了奔流外科的60个糖尿病的病人的92只眼睛在外科前被评估并且1，在用10月有斑点的厚度的外科以后的3mo在九有斑点的子字段与10月被测量定义b另外，开发的发生或我变得更坏在糖尿病的眼睛被分析与或没有先存在，ME.RESULTSThe中央子字段平均数厚度增加了21.0µ；m和25.5µ；在1点的m，3mo后续，分别地(P<；0.01)。内部戒指和外部戒指的平均厚度增加了14.2µ；m和9.5µ；在1mo的m，18.2µ；m和12.9µ；在3mo的m。中央包含我在3mo在12只眼睛发展了，包括4与先存在与先存在看中央包含和8只眼睛非中央包含了我。先存在的糖尿病的有斑点的浮肿(DME)显著地与中央包含被联系我开发(P<；0.001).CONCLUSIONA尽管增加是温和的，统计上重要的增加能在中央子字段以及perifoveal和parafoveal部门被检测。并且有在奔流外科以前的外科手术前的DME的眼睛在为开发中央包含的更高的风险我。

简介：AIM:Toinvestigatetheprevalenceandriskfactorsofdiabeticretinopathy(DR)innorthernChinesepatientswithtype2diabetesmellitus(T2DM).METHODS:Thisretrospectivecross-sectionalstudywasperformedbetweenMay2011andApril2012.Atotalof1100patients(male/female,483/617)wereincludedinthisstudy.DRwasdefinedfollowingtheEarlyTreatmentDiabeticRetinopathyStudy(ETDRS)severityscale.Allincludedpatientsacceptedacomprehensiveophthalmicexaminationincludingretinalphotographs.Logisticregressionmodelswereusedtoestimateoddsratios(ORs)and95%confidenceinterval(CI)afteradjustingforageandgender.RESULTS:Retinopathywaspresentin307patientswithaprevalenceof27.9%.Inunivariatelogisticanalysis,presenceofDRwasassociatedwithlongerdurationofdiabetes(OR,5.70;95%CI,2.91-12.56),higherconcentrationoffastingbloodglucose(OR,12.94;95%CI,2.40-67.71),higherlevelofglycosylatedhemoglobinHbA1c(OR,5.50;95%CI,3.78-11.97)andinsulintreatment(OR,6.99;95%CI,1.39-35.12).ThelifestyleofpatientswithT2DMincludingsmoking,alcoholconsumptionandregularexerciseseemednotassociatedwiththedevelopmentofDR.CONCLUSION:Ourstudysuggeststhatfastingserumglucoseconcentration,HbA1clevel,durationofdiabetesandinsulintreatmentarepotentialriskfactorsforDRinnorthernChinesepatientswithT2DM,whilethelifestyleofincludedpatientsseemsnotassociatedwithDR.

简介：AIM:Toestablishtheratmodelofstreptozotocin(STZ)induceddiabeticretinopathy(DR),whichisthemostcommoncauseofvisuallossandblindnessinpatientswithdiabetes,andobservethegeneexpressionofvascularendothelialgrowthfactor(VEGF)anditsreceptorsduringthedevelopmentofDR.METHODS:AratmodelofdiabeteswasestablishedbyintraperitonealinjectionofSTZ.Thediabeticratswerehousedfor2,3and4monthsafterthedevelopmentofdiabetes.Retinalhistopathologicalobservationwasperformed.TheretinalvesselswereobservedbyimmunofluorescencestainingbyCD31.ThemRNAexpressionofVEGF,VEGFreceptor1and2(VEGFR1/2)inratretinawasdetectedbyreversetranscriptionpolymerasechainreaction(RT-PCR)analysis.RESULTS:Retinalhistopathologicalobservationshowedthemorphologicalchangesofinnernuclearlayer(INL)andouternuclearlayer(ONL)atanytime-point,andalsodemonstratedtheincreasednewvesselsatboth3,4monthsafterthedevelopmentofdiabetes.TheCD31stainingresultsshowedthatthenumberofvesselswasincreasedintheretinasofdiabeticratsatboth3and4monthsafterthedevelopmentofdiabetes.Ascomparedtothenormalrats,themRNAexpressionofVEGFwasincreasedinretinasofdiabeticratsat3monthsafterthedevelopmentofdiabetes,whileVEGFR1andVEGFR2mRNAexpressionwasincreasedat2,3and4monthsafterthedevelopmentofdiabetes.CONCLUSION:Takentogether,ourresultsdemonstratedthatDRwasoccurredat3monthsafterthedevelopmentofdiabetes,andthemRNAexpressionofVEGF,VEGFR1andVEGFR2wereincreasedintheprocessofDR.ThepresentstudyfurtherevidencedtheinvolvementofVEGFanditsreceptorsintheprocessofDR.

简介：AIMTo与类型2糖尿病mellitus(T2DM)在中国病人的一个队调查在C反应的蛋白质(CRP)和糖尿病的retinopathy(医生)之间的关系基于.METHODSCommunity的观察的队学习。有1131个参加者，在城市的北京在Desheng社区从2009年11月招募到2011年9月。病人们诊断了T2DM被招募并且经历由一张问询表，眼睛、人体测量的检查和实验室调查组成的标准化评估。医生的存在和严厉由七个领域被估计30°；渲染宫底相片。题目然后没有医生，任何医生，或威胁视觉的克尔普博士被分类进组与T2DM从1007个病人全部的学习subjects.RESULTSA的浆液被分析为分析被包括，包括408(40.5%)男人并且599(59.5%)女人。中部的CRP水平为男人是为女人和1.1mg/L的1.5mg/L(P=0.004，或0.37，95%CI0.18-0.74)。在为可能的covariates调整以后，CRP的高水平与任何医生的更低的流行被联系(P=0.02，或0.55，95%CI0.35-0.89)，然而并非与威胁视觉的医生联系了(P=0.62，或0.78，95%CI0.28-2.14)。在由性的层化以后，在CRP和医生之间的反的协会被发现在男人统计上重要(P=0.006，或0.35，95%CI0.16-0.73)，然而并非在女人(P=0.58，或0.88，95%CI0.29-1.16)与T2DM从一张中国人口拉的.CONCLUSIONThe数据建议那增加的CRP层次可以相反地与医生的开发被联系。

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简介：在反脉管的endothelial生长的一个年以后与有斑点的浮肿的分辨率和foveal消沉的恢复在眼睛报导foveal厚度减小为包含中心的糖尿病的有斑点的浮肿(DME)的因素(anti-VEGF)治疗.METHODSFoveal厚度与光连贯断层摄影术被估计决定中央子字段foveal厚度(CSFT)并且在有DME的42只眼睛的有斑点的体积(CSFT>275湥獴愠?潣灭牡摥琠?敨污桴?潣瑮潲?牧畯？

简介：AIMTo评估热门non-steroidal的预防管理的功效在糖尿病的病人的有斑点的浮肿追随者奔流外科上的反煽动性的药(NSAID)，并且在NSAID的类型之间比较(ketorolactromethamine0.4%并且nepafenac0.1%).METHODSGroup(控制)1作为一个安慰剂组接待了人工的眼泪代用品，(nepafenac)组2收到了热门nepafenac(ketorolac)0.1%，和组3收到了热门ketorolactromethamine0.4%。病人们在完成一个以后手术后地被检查为评估似胞的有斑点的浮肿(CME)的星期，一个月，二个月和三月间隔开发。主要学习结果在与光连贯地形学(10月)测量的中央有斑点的厚度(CMT)正在完成最好改正的视觉尖酸(BCVA)和变化76个病人的.RESULTSEighty眼睛在这研究被包括。BCVA在第三个月显示出统计上重要的差别手术后列在后面在上面在控制组和NSAID组(P=0.04)之间。在开始从的所有情况中的CMT有增加手术后第一个星期直到第三个月。CMT显示出控制组和NSAID组之间的统计上重要的差别从手术后第一个月直到第三个月(P=0.008，0.027，0.004)。在BCVA和外科手术前的10月CMT.CONCLUSIONProphylacticnepafenac和ketorolac组之间没有统计上重要的差别，手术后的NSAID可以在在跟随奔流外科的糖尿病的眼睛减少CME的频率和严厉有一个角色。

简介：AIMTo估计intravitrealtriamcinoloneacetonide(IVTA)的可能的好处注射作为为在有糖尿病的有斑点的浮肿(DME)的病人的有斑点的激光光致疑结(MLP)的预告的处理，.METHODSPublished使随机化有关MLP与或没有为DME的IVTA预告的处理的控制试用(RCT)从数据库CNKI被检索，Medline，EMbase，科学的网，和Cochrane图书馆。合格研究上的元分析用RevMan5.0软件被进行。二个调查者独立地估计了试用的质量并且提取了数据。主要结果措施在最好改正的视觉尖酸(BCVA)包括了变化，在中央有斑点的厚度(CMT)的差别并且不利事件报导特别地在后续时期以内提高了intraocular压力。结果用重量平均数差别(WMD)或机会风险被分享(或)与他们的相应95%信心间隔(CI)。改正效果或随机效果的模型被采用trials.RESULTSFinally取决于包括的异质，五独立RCT被识别并且使用了独自与MLP把MLP与IVTA预告的处理(131只眼睛)作比较(133只眼睛，控制组)。全面学习质量根据修改Jadad规模是相对更高的。元分析证明有IVTA预告的处理的MLP显著地在一，三和六个月减少了CMT(P=0.002，0.0003和0.04，分别地)，与MLP相比独自一个。IVTA预告的处理组证明在在一个月的BCVA的统计上重要的改进列在后面在上面作为与控制组(P=0.03)相比。在三月、六月列在后面在上面，向没有在组之间的统计意义，在IVTA预告的处理组改进视觉尖酸有一个有益的趋势(P=0.06并且0.20，分别地)。intraocular压力的举起的发生比在控制组在IVTA预告的处理组是显著地更高的(P<；0.0001)。出版偏爱的证据都不根据Begg的测试和Egger的测试是在场的。有在包括的studies.CONCLUSIONThis元分析的异质的底层显示有IVTA预告的处理的MLP以CMT有更好治疗学的效果减小并且更早(1mo)为有DME的病人的视觉改进