简介：BACKGROUND:Pattern-visualevokedpotential(PVEP)canreflectthefunctionalstatusofretinalganglialcells(RGC)andvisualcortex,andisanobjectiveexaminationforvisualpathwayfunction.Itisauniquemethodforobjectivelyexaminingtheopticnervefunctionofopticganglioncells.OBJECTIVE:Toobservetheeffectsofnervegrowthfactor(NGF)onPVEFinthetreatmentofopticnervecontusion,evaluatetheclinicalefficacyofNGF,andmakeanefficacycomparisonwithvitaminB12.DESIGN:Arandomlygrouping,controlledobservation.SETTING:DepartmentofOphthalmology,TangshanGongrenHospitalAffiliatedtoHebeiMedicalUniversity.PARTICIPANTS:Fortypatientswithopticnervecontusioncausedbyeyetrauma,whoreceivedthetreatmentintheTangshanWorkerHospitalAffiliatedtoHebeiMedicalUniversitybetweenJanuary2006andJune2007,wererecruitedinthisstudy.Theinvolved40patients,including34malesand6females,wereaged14-59years.TheywereconfirmedtohaveopticnervecontusionbyophthalmologicconsultationcombinedwithhistoryofdiseaseandorbitalCTexamination.Informedconsentsoftreatmentsanddetecteditemswereobtainedfromallthepatients.Thepatientswererandomlydividedinto2groupswith20ineach:NGFgroupandvitaminB12group.METHODS:Conservativetreatmentwasusedinthetwogroups.Inaddition,patientsintheNGFgroupwereintramuscularlyinjectedwithNGFsolution18μg/time,onceaday.ThoseinthevitaminB12groupwereinjectedbythesamemethodwithcommonvitaminB12of500μgcombinedwithvitaminB1of100mg,onceaday.MAINOUTCOMEMEASURES:PVEPexaminationwasconductedinallthepatientsbefore,oneandtwoweeksaftertreatment,andlatencyandamplitudeatP100weredetected.RESULTS:Fortypatientswithopticnervecontusionparticipatedinthefinalanalysis.Beforetreatment,significantdifferencesinthelatencyandamplitudeatP100werenotfoundinpatientsbetweentwogroups(P>0.05).ForeachpatientintheNGF

简介：

简介：BACKGROUND:Conventionalmethods(suchasocclusiontherapy,finemanipulation,complementary,andalternativemedicine)takeeffectsslowly,aretimeandlaborconsuming,andhaveuncertaincurativeeffectsinthetreatmentofamblyopia.Perceptuallearning,anewmethodfortreatingamblyopia,improvestheabilitytoprocesssignalsfromthecerebralopticnervesystembyspecificvisualstimulationandvisuallearning,aswellasactivationofthevisualsignalpathwayutilizingbrainnervoussystemplasticity.OBJECTIVE:Thisstudyinvestigatedandevaluatedthecurativeeffectsofperceptuallearning,whichcandirectionallyincreasebrainplasticity,onthetreatmentofamblyopiainchildren.Therelationshipbetweencurativeeffectandtimewasalsoanalyzed.DESIGN:Aself-controlexperiment.SETTING:VisualScienceandOptometryCenter,People'sHospitalofGuangxiZhuangAutonomousRegion.PARTICIPANTS:Atotalof125amblyopicchildren(250amblyopiceyes),73males,52females,averaging(6±2)yearsofage,receivedtreatmentattheVisualScienceandOptometryCenter,People'sHospitalofGuangxiZhuangAutonomousRegionbetweenSeptember2006andFebruary2007andwererecruitedforthisstudy.Allchildrenpresentedwithnostructuraldiseaseoftheeyeballs.Writteninformedconsentfortherapeuticregimentswasobtainedfromeachchild'sparent.TheprotocolreceivedapprovalfromtheHospital'sEthicsCommittee.METHODS:Visualfunctionwastestedwithaperceptuallearningsystem(ResearchCenterforHumanHealthandDevelopmentofSunYat-senUniversity,NationalEngineeringTechniqueResearchCenterforMedicalCareImplement)forvisualnoise,positionnoise,contourdiscrimination,contrastsensitivity,gratingstereogram,andrandom-dotfusion.Thesetestshelpedtoevaluatetheefficiencyofvisualinformationprocessingofthesechildren,andtodeterminethedegreeofdefectsoftheopticnervecellsandtheconnectionsofvisualcorticalneurons.Accordingtoresultsofvisualfunct

简介：BACKGROUND:Functionalmagneticresonanceimaging(fMRI)isinitiallyusedforvisualcortexlocation.However,theapplicationoffMRIininvestigatingthedevelopmentofvisualpathwaylesionsneedstobefurtherobserved.OBJECTIVE:Thisstudyistolongitudiallyobservethedynamicchangesincorticalfunctionandwhitematterfibrousstructureofpatientswithvisualpathwaylesionsbybloodoxygenationleveldependent-functionalmagneticresonanceimaging(BOLD-fMRI)combinedwithdiffusiontensorimaging(DTI),andtoanalyzethecharacteristicsofbrainfunctionandstructuralrecombinationatconvalescentperiodoflesions.DESIGN:Randomizedcontrolledobservation.SETTING:DepartmentofRadiology,theGeneralHospitalofNanjingMilitaryAreaCommandofChinesePLA.PARTICIPANTS:Eightpatientswithunilateralorbilateralvisualdisordercausedbyvisualpathwaylesions,whoadmittedtoDepartmentofRadiology,theGeneralHospitalofNanjingMilitaryAreaCommandofChinesePLAfromJanuarytoSeptember2006wereinvolved,andservedasexperimentalsubjects.Thepatients,6malesand2females,wereaged16-67years.Theyhadvisualdisorderconfirmedbyclinicalexamination,i.e.visualpathwaylesion,whichwasfurtherdiagnosedbyMRorCT.Another12subjectsgenerallymatchingtothosepatientsofexperimentalgroupingender,ageandsight,whoreceivedhealthexaminationinsynchronizationwereinvolvedandservedascontrols.Thesubjectshadnohistoryofeyediseases.Theirbinocularvisualacuity(orcorrectedvisualacuity)wasover1.0.Bothroutineexaminationofophthalmologyandexaminationoffunduswerenormal.Informedconsentsofdetecteditemswereobtainedfromallthesubjects.METHODS:SignaExciteHD1.5Tmagneticresonanceimagingsystemwith16passages(GECompany,USA)andcoilwith8passageswereused;brainfunctionalstimulusapparatus(SAV-8800.MeideCompany)wasusedforshowingexperimentalmission.Attheearlystageandconvalescentperiodoflesions,thepatie