简介：Weobservedthecharacteristicsofwhitematterfibersandgraymatterinmultiplesclerosispatients,toidentifychangesindiffusiontensorimagingfractionalanisotropyvaluesfollowingwhitematterfiberinjury.Weanalyzedthecorrelationbetweenfractionalanisotropyvaluesandchangesinwhole-braingraymattervolume.Theparticipantsincluded20patientswithrelapsing-remittingmultiplesclerosisand20healthyvolunteersascontrols.Allsubjectsunderwentheadmagneticresonanceimaginganddiffusiontensorimaging.Ourresultsrevealedthatfractionalanisotropyvaluesdecreasedandgraymattervolumeswerereducedinthegenuandspleniumofcorpuscallosum,leftanteriorthalamicradiation,hippocampus,uncinatefasciculus,rightcorticospinaltract,bilateralcingulategyri,andinferiorlongitudinalfasciculusinmultiplesclerosispatients.Graymattervolumesweresignificantlydifferentbetweenthetwogroupsintherightfrontallobe(superiorfrontal,middlefrontal,precentral,andorbitalgyri),rightparietallobe(postcentralandinferiorparietalgyri),righttemporallobe(caudatenucleus),rightoccipitallobe(middleoccipitalgyrus),rightinsula,rightparahippocampalgyrus,andleftcingulategyrus.Thevoxelsizesofatrophicgraymatterpositivelycorrelatedwithfractionalanisotropyvaluesinwhitematterassociationfibersinthepatientgroup.Thesefindingssuggestthatwhitematterfiberbundlesareextensivelyinjuredinmultiplesclerosispatients.Themainareasofgraymatteratrophyinmultiplesclerosisarethefrontallobe,parietallobe,caudatenucleus,parahippocampalgyrus,andcingulategyrus.Graymatteratrophyisstronglyassociatedwithwhitematterinjuryinmultiplesclerosispatients,particularlywithinjurytoassociationfibers.

简介：Insularlesionsremainsurgicallychallengingbecauseoftheneedtobalanceaggressiveresectionandfunctionalprotection.Motorfunctiondeficitsduetocorticospinaltractinjuryareacommoncomplicationofsurgeryforlesionsadjacenttotheinternalcapsuleanditisthereforeessentialtoevaluatethecorticospinaltractadjacenttothelesion.Weuseddiffusiontensorimagingtoevaluatethecorticospinaltractin89patientswithinsularlobelesionswhounderwentsurgeryinChinesePLAGeneralHospitalfromFebruary2009toMay2011.Postoperativemotorfunctionevaluationrevealedthat57patientshadnochangesinmotorfunction,and32patientssufferedmotordysfunctionoraggravatedmotordysfunction.Oftheaffectedpatients,20recoveredmotorfunctionduringthe6-12-monthfollow-up,andanadditional12patientsdidnotrecoverovermorethan12monthsoffollow-up.Followingreconstructionofthecorticospinaltract,fractionalanisotropycomparisondemonstratedthatpreoperative,intraoperativeandfollow-upnormalizedfractionalanisotropyinthestablegroupwashigherthaninthetransientdeficitsgrouporthelong-termdeficitsgroup.Comparedwiththetransientdeficitsgroup,intraoperativenormalizedfractionalanisotropysignificantlydecreasedinthelong-termdeficitsgroup.Weconcludethatintraoperativefractionalanisotropyvaluesofthecorticospinaltractscanbeusedasaprognosticindicatorofmotorfunctionoutcome.

简介：BACKGROUND:Functionalmagneticresonanceimaging(fMRI)isinitiallyusedforvisualcortexlocation.However,theapplicationoffMRIininvestigatingthedevelopmentofvisualpathwaylesionsneedstobefurtherobserved.OBJECTIVE:Thisstudyistolongitudiallyobservethedynamicchangesincorticalfunctionandwhitematterfibrousstructureofpatientswithvisualpathwaylesionsbybloodoxygenationleveldependent-functionalmagneticresonanceimaging(BOLD-fMRI)combinedwithdiffusiontensorimaging(DTI),andtoanalyzethecharacteristicsofbrainfunctionandstructuralrecombinationatconvalescentperiodoflesions.DESIGN:Randomizedcontrolledobservation.SETTING:DepartmentofRadiology,theGeneralHospitalofNanjingMilitaryAreaCommandofChinesePLA.PARTICIPANTS:Eightpatientswithunilateralorbilateralvisualdisordercausedbyvisualpathwaylesions,whoadmittedtoDepartmentofRadiology,theGeneralHospitalofNanjingMilitaryAreaCommandofChinesePLAfromJanuarytoSeptember2006wereinvolved,andservedasexperimentalsubjects.Thepatients,6malesand2females,wereaged16-67years.Theyhadvisualdisorderconfirmedbyclinicalexamination,i.e.visualpathwaylesion,whichwasfurtherdiagnosedbyMRorCT.Another12subjectsgenerallymatchingtothosepatientsofexperimentalgroupingender,ageandsight,whoreceivedhealthexaminationinsynchronizationwereinvolvedandservedascontrols.Thesubjectshadnohistoryofeyediseases.Theirbinocularvisualacuity(orcorrectedvisualacuity)wasover1.0.Bothroutineexaminationofophthalmologyandexaminationoffunduswerenormal.Informedconsentsofdetecteditemswereobtainedfromallthesubjects.METHODS:SignaExciteHD1.5Tmagneticresonanceimagingsystemwith16passages(GECompany,USA)andcoilwith8passageswereused;brainfunctionalstimulusapparatus(SAV-8800.MeideCompany)wasusedforshowingexperimentalmission.Attheearlystageandconvalescentperiodoflesions,thepatie

简介：BACKGROUND:Intracerebralhemorrhage(ICH)andcoronaryheartdisease(CHD)havethesamepathologicalbase,atherosclerosis,andthesimilarriskfactors,suchassmoking,drinking,hypertension,hyperlipemia,diabetesmellitus,etc;butthedistributionsoftwodiseasesareverydifferentinthepopulations.Thismayberelatedtotheexposureofriskfactorsanddifferenteffectsofriskfactorsontwodiseases.OBJECTIVE:ToanalyzethedistributiondifferenceofriskfactorsforICHandCHDinthepopulationsofTongliaocityofNeiMonggolAutonomousRegion.DESIGN:Retrospectiveanalysis.SETTING:SchoolofRadiationMedicineandPublicHealth,SoochowUniversity;TongliaoHospital,NeiMonggolAutonomousRegion.PARTICIPANTS:Randomsamplingwasusedtoselect6hospitalsfrom10hospitalsaffiliatedtoTongliaoCityofNeiMonggolAutonomousRegion.Totally1672medicalrecordsofpatientswithICHand2195medicalrecordsofpatientswithCHDadmittedtoDepartmentofNeurologyandDepartmentofCardiovascularInternalMedicineofabove-mentioned6hospitalsbetweenJanuary2003andDecember2005werecollectedaccordingtotheinvestigationneed.METHODS:Thesubjects,whosemedicalrecordswereinvolved,wereperformedretrospectiveanalysiswithpre-preparedquestionnaire'StrokeandCoronaryHeartDiseaseEpidemiologicQuestionnaire'.Themaincontentsincluded:①Socialdemographycondition:Thedistributionsofgender,age,nationality,etc.②Previoushistoryofdisease:hypertension,diabetesmellitus,etc.③Relatedriskfactors:systolicbloodpressure,diastolicbloodpressure,totalcholesterol,triglyceride,high-densitylipoproteincholesterol,low-densitylipoproteincholesterol,smoking,drinkingandglucose(GLU).ThedatabaseofEpidatawastransformedtoSPSSdatabase.Single-andmultiple-factornon-conditionalLogisticregressionanalysiswereperformedonthedata,andORvalueand95%CIwerecalculated.Thedistributiondifferencesofriskfactorsfortwodiseaseswerecompared