简介：AIMToevaluatewhetherindividualswithgastriccancer（GC）arediagnosedearlieriftheyhavefirstdegreerelativeswithGC.METHODS：Atotalof4282patientsdiagnosedwithGCatNationalCancerCenterHospitalfrom2002to2012wereenrolledinthisretrospectivestudy.Weclassifiedthepatientsaccordingtopresenceorabsenceoffirst-degreefamilyhistoryofGCandcomparedageatdiagnosisandclinicopathologiccharacteristics.Inaddition,wefurtherclassifiedpatientsaccordingtospecificfamilymemberwithGC（father,mother,sibling,oroffspring）andcomparedageatGCdiagnosisamongthesepatientgroups.Baselinecharacteristicswereobtainedfromaprospectivelycollecteddatabase.Informationaboutthefamilymember＇sageatGCdiagnosiswasobtainedbyquestionnaire.RESULTS：Atotalof924patients（21.6%）hadafirstdegreefamilyhistoryofGC.ThemeanageatGCdiagnosisinpatientshavingpaternalhistoryofGCwas54.4±10.4yearsandwassignificantlyyoungerthaninthosewithoutafirst-degreefamilyhistory（58.1±12.0years,P〈0.001）.However,thisfindingwasnotobservedinpatientswhohadanaffectedmother（57.2±10.0years）orsibling（62.2±9.8years）.Amongpatientswithfamilymemberhavingearly-onsetGC（〈50yearsold）,meanageatdiagnosiswas47.7±10.3yearsforthosewithanaffectedfather,48.6±10.4yearsforthosewithanaffectedmother,and57.4±11.5yearsforthosewithanaffectedsibling.Thus,patientswithaparentdiagnosedbefore50yearsofagedevelopedGC10.4or9.5yearsearlierthanindividualswithoutafamilyhistoryofGC（bothP〈0.001）CONCLUSION：Early-onsetGCbeforeageof50wasassociatedwithparentalhistoryofearly-onsetofGC.Individualhavingsuchfamilyhistoryneedtostartscreeningearlier.