简介：CardiovascularimmunologyresearchinWuhanUnionHospitalbeganin1991.Anti-heartantibodiesindilatedcardiomyopathyandacuteviralmyocarditisbegantobereportedfrom1993.ItwasfoundthatanewautoantibodyagainstL-typecalciumchannelresultsinventriculartachycardiaandsuddendeathinpatientswithdilatedcardiomyopathy.ThroughtheInterventionStudyofDiltiazeminDilatedCardiomyopathy,diltiazemwasverifiedtoreducemortalityandthechronicheartfailurehospitalizationratesignificantlyinpatientswithdilatedcardiomyopathy.TheautoantibodiesagainstangiotensinIIreceptortype1andα1-adrenoceptorwereassociatedwiththeincreasedrecurrenceofanddeathfromstrokeinhypertensivepatients.Throughmanyclinicalandexperimentalstudies,thefunctionalimbalanceofT-cellsubsetswassuggestedtomediatemyocardialinjuryandchronicheartfailure,whichprovidedanewtheoreticalbasisforimmunoregulationtherapyforheartfailure.Thefirstantihypertensivepolypeptidevaccine(ATRQβ-001)wasinvented.Inadditiontotheseachievements,therewillbemoreresearchoncardiovascularimmunologyinWuhanUnionHospitalinthefuture.

简介：BackgroundValvularheartdisease(VHD)isdefinedasastructuralorfunctionalabnormalityincardiacvalvewhichencompassesanumberofcommoncardiovascularconditions.ThisstudywasaimedtoanalyzetheepidemiologicalchangesofVHDinasinglecardiovascularcenterofSouthernChina.MethodsAtotalof13,138VHDpatientsofGuangdonggeneralhospitalfromJanuary2011toDecember2013werescreenedbytransthoracicechocardiography(TTE)ortransesophagealechocardiography(TEE)andenrolledforthisstudy.Themorbidity,etiologicalspectrumandmanagementofthesepatientswereanalyzed.Continuousvariableswereexpressedasmean±standarddeviation.Categoricalvariableswereexpressedasratioorpercentage.ResultsPatientsinthisstudyweredividedintodifferentgroupsandwereanalyzedthroughoutchangesinmorbidity,etiologicalspectrumandmanagement.ConclusionsTheprevalenceofVHDremainshighinSouthernChinaandRHDisstilltheleadingetiologyofVHD.Butmorbidityrateisreducedandsurgeryisstillthemaintreatmentoption.