简介：BackgroundAlthoughmiRNAshavebeenshowntoassociatewithavarietyofdiseases,whethermiRNAsinmonocyteassociateheartfailure(HF)hasbeennotwellstudied.MethodsEightpatientswithischemicHF(IHF),8patientswithnon-ischemicHF(NIHF)and8healthyvolunteerswererecruited.Clinicalcharacteristicsofallparticipantswerecollected.PeripheralbloodsamplesweredrawnforanalysisofmiRNAexpressioninmonocytes.ResultsAllparticipantsweremaleandtheparticipantsinIHFgroupwereolderandhadhigherpercentageofsmokeranddiabetesmellitusthanintheothertwogroups(P<0.05).SerumlevelsofcreatinineandNT-proBNPweresignificantlyhigherinIHFpatientscomparedtotheothertwogroups(P<0.05).MoreparticipantsinIHFgroupweretreatedwithACEI/ARB,beta-blockerandstatins.ParticipantswithNYHAgradeIIIaccountedfor62.5%inIHFgroup,whileparticipantswithNYHAgradeIVaccountedfor87.5%inNIHFgroup.Thelevelsof11miRNAsinmonocytesweresignificantlyhigherintheIHFgroup,andthelevelsof7miRNAsweresignificantlyincreasedintheNIHFgroup.OtherdifferencesinmiRNAslevelsbetweenIHFandNIHFgroupswerealsoobserved.ConclusionourpresentstudyrevealedthattherearesubstantialdifferencesinmiR-NAsbetweenHFpatientsandhealthyvolunteer.

简介：BackgroundStudieshaveshownthatmiRNA-155playedanimportantroleintheprocessofdevelopmentofhypertension.However,thereisnodateaboutmiRNA-155andbloodpressuremonitoringparameters.Therefore,weexaminedwhetherinhypertensivepatientstheexpressionlevelofplasmamiRNA-155relatedto24-hambulatorybloodpressuremonitoring(ABPM)parameters.MethodsAcohortofadultpatientsscheduledtoreceivephysicalexamination,officeandambulatorybloodpressuremonitoring.Quantitativereversetranscriptasepolymerasechainreaction(qRT-PCR)wasusedtoevaluatetheexpressionofselectedmiRNA-155.ThemiRNA-155expressionlevelcorrelationbetweenbloodpressureparameterswasassessedusingtheSpearmancorrelationcoefficient.ResultsFiftyfouressentialhypertensionpatients(25men;meanage,53.28±9.52years)andthirtyhealthyvolunteers(15men;meanage,53.03±5.87years)wereincluded.WeobservedhigherexpressionlevelofmiRNA-155(32.31±2.85vs27.21±1.59,P<0.001)inhypertensivepatientscomparedtohealthycontrolindividuals.MiRNA-155expressionlevelshowedsignificantpositivecorrelationwith24hDaytimeSBP(r=0.681,P<0.001),24hDaytimeDBP(r=0.473,P<0.001),24hDaytimePP(r=0.565,P<0.001)anddipping(r=0.257,P=0.018),respectively.ConclusionsOurstudyshowedthatmiRNA-155expressionlevelwasassociatedpositivelywithdaytimebloodpressuremonitoringparameters,aswellasbloodpressurevariability,indicatingapossibleimplicationofmiRNA-155inthepathogenesisofhypertension.

简介：扩张型心肌病（DCM）是非缺血性心肌病中最普遍的类型,预后差,死亡率高。近年来的研究发现,非编码小分子RNA（miRNA）与DCM的病程密切相关。本文就miRNA的表达模式与DCM发展的相关研究进行综述。