简介：为了评估antithyroidantibodie层次，有甲状腺疾病的526个病人和292健康的意义，从Yuci使区域遭到，山西省，中国，被学习。浆液层次为甲状腺荷尔蒙受体抗体(TRAb)被决定，microsomal抗体(TMAb)和thyrogiobulin抗体(TGAb)。在病人之中，为榴状的甲状腺肿和甲状腺腺瘤，坟的疾病，和Hashimoto的甲状腺炎的百分比分别地是44.1%，19.6%和17.7%。到男性的女性的比率是2.0～15.6个.Antibody积极的病人因为TMAb，TGAb和TRAb为Hashimoto的甲状腺炎作为94.6%，76.3%和20.4%可检测，并且40.0%，30.0%和90.3%为格雷夫斯的疾病。为描绘疾病和forusingas的流行病学的基础在结论，在Hashimoto的甲状腺炎和自发的甲状腺机能减退的TGAb/TMAb的在坟的疾病的TRAb的高水平，和那些是有意义的为在单个病人的恶化的预示的指示物。

简介：Toinvestigatetheexpressionofapoptosis-relatedprotein(Fas,FasL,andBcl-2)inthepathogenesisofautoimmunethyroiddisorders(ATDs),immunohistochemicalstainingwasperformedon20Hashimoto'sthyroiditis(HT),20Graves'disease(GD),and20thyroidfollicularadenoma(TFA,ascontrol).AllthecasesexpressedFas,mainlyonthecellsurfaceandcytoplasm.FasLwasfoundin17casesoftheTFA.Bcl-2wasdetectedin15casesofHT,19ofGDand17ofTFA.InTFA,amoderateFasexpressionandaminimalornoFasLexpressionwasdetectedonfollicularcells.InHT,thefolliclesadjacenttoinfiltratinglymphocytesshowedincreasedlevelsofFasandFasLexpression.AweakerstainingofFasandFasLwasexhibitedoninfiltratinglymphocytesthanonthyrocytes.InacomparisonofGDwithHT,thyrocytesandlymphocytesshowedsimilarFasstaining,butforFasLthestainingwasratherweakerinHT.TheexpressionofBcl-2wasnearlyidenticalinGDandTFA,butmuchweakeronthefollicularcellsinvicinityoflymphocytesandonthelymphocyteslocatedingerminalcentersofHTtissues.TheexpressionofFas,FasL,Bcl-2inHashimoto'sthyroiditisandGraves'diseasewerealmostsame.FasLstrongexpressionandBcl-2weakexpressiononthefolliclesinHTmayinduceapoptosis.TheseresultsprovidedevidenceforexpressionofFas,FasLandBcl-2inthepathogenesisofautoimmunethyroiddisease.ThelymphocytesseemnottobedirectlyengagedintheprocessviatheirownFasL,buttheymayprovidesomecytokinesthat,inturn,upregulateFasand/orFasLexpressiontoinduceapoptosis.